0000936392-07-000940 Sample Contracts

AMENDMENT No. 3 TO LICENSE AGREEMENT

License Agreement • December 14th, 2007 • Orexigen Therapeutics, Inc. • Pharmaceutical preparations

• Contract Type
  License Agreement
• Filed
  December 14th, 2007
• Company
  Orexigen Therapeutics, Inc.
• Industry
  Pharmaceutical preparations

This Amendment No. 3 (“Amendment”) dated as of December 7, 2007 (“Effective Date”) is made and entered into by and between Oregon Health & Science University (“OHSU”) and Orexigen Therapeutics, Inc. (“Licensee”).

TORREY PINES COURT, LA JOLLA OFFICE LEASE LANDLORD: MULLROCK 3 TORREY PINES, LLC, a Delaware limited liability company TENANT: OREXIGEN THERAPEUTICS, INC., a Delaware corporation

Work Letter Agreement • December 14th, 2007 • Orexigen Therapeutics, Inc. • Pharmaceutical preparations • California

• Contract Type
  Work Letter Agreement
• Filed
  December 14th, 2007
• Company
  Orexigen Therapeutics, Inc.
• Industry
  Pharmaceutical preparations
• Jurisdiction
  California

This LEASE, which includes the preceding Summary of Basic Lease Information and Definitions (“Summary”) attached hereto and incorporated herein by this reference (“Lease”), is made as of the 7th day of December, 2007, by and between MULLROCK 3 TORREY PINES, LLC, a Delaware limited liability company (“Landlord”), and OREXIGEN THERAPEUTICS, INC., a Delaware corporation (“Tenant”).