0000936392-06-001081 Sample Contracts

INDEMNIFICATION AGREEMENT
Indemnification Agreement • November 27th, 2006 • Artes Medical Inc • Pharmaceutical preparations • Delaware

Both the Company and Indemnitee recognize that highly competent persons have become more reluctant to serve publicly-held corporations as directors or in other capacities unless they are provided with adequate protection through insurance or adequate indemnification against inordinate risks of claims and actions against them arising out of their service to and activities on behalf of the corporation.

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ARTES MEDICAL, INC. LOAN AND SECURITY AGREEMENT
Loan and Security Agreement • November 27th, 2006 • Artes Medical Inc • Pharmaceutical preparations • California

This LOAN AND SECURITY AGREEMENT is entered into as of November 27, 2006, by and between COMERICA BANK (“Bank”) and ARTES MEDICAL, INC. (“Borrower”).

ARTES MEDICAL, INC. AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT
Investors’ Rights Agreement • November 27th, 2006 • Artes Medical Inc • Pharmaceutical preparations • California

THIS AMENDED AND RESTATED INVESTORS’ RIGHTS AGREEMENT (this “Agreement”), is made and entered into as of June 23, 2006, by and among Artes Medical, Inc., a Delaware corporation (the “Company”), and each of the individuals or entities whose names are set forth on Schedule A hereto (each, a “Stockholder” and collectively, the “Stockholders”).

AMENDMENT TO COMMON STOCK PURCHASE WARRANT OF ARTES MEDICAL, INC. (Issued in Connection with Services Provided)
Common Stock Purchase Warrant • November 27th, 2006 • Artes Medical Inc • Pharmaceutical preparations • California

This Amendment dated as of June 23, 2006 (this “Amendment”), to each of the Common Stock Purchase Warrants (each, a “Warrant” and collectively, the “Warrants”) for the purchase of shares of Common Stock of Artes Medical, Inc. (the “Company”) listed on Exhibit A hereto, is made by and between the Company and each of the holders of one or more Warrants listed on Exhibit A (each, a “Holder” and collectively, the “Holders”).

AMENDMENT TO WARRANT TO PURCHASE SERIES D PREFERRED STOCK OF ARTES MEDICAL, INC. (Issued in Connection with Interim Credit Facility 2005)
Artes Medical Inc • November 27th, 2006 • Pharmaceutical preparations • California

This Amendment dated as of June 23, 2006 (this “Amendment”), to each of the Warrants to Purchase Series D Preferred Stock (each, a “Warrant” and collectively, the “Warrants”) for the purchase of shares of Series D Preferred Stock of Artes Medical, Inc. (the “Company”), is made by and between the Company and each of the holders of one or more Warrants listed on Exhibit A (each, a “Holder” and collectively, the “Holders”).

AMENDMENT TO SHARE PURCHASE WARRANT OF ARTES MEDICAL, INC. (Issued in Connection with Bridge Loan 2002)
Artes Medical Inc • November 27th, 2006 • Pharmaceutical preparations • California

This Amendment dated as of June 23, 2006 (this “Amendment”), to each of the Share Purchase Warrants (each, a “Warrant” and collectively, the “Warrants”) for the purchase of shares of Series C-1 Preferred Stock of Artes Medical, Inc. (the “Company”) listed on Exhibit A hereto, is made by and between the Company and each of the holders of one or more Warrants listed on Exhibit A (each, a “Holder” and collectively, the “Holders”).

Contract
Artes Medical Inc • November 27th, 2006 • Pharmaceutical preparations • California

THIS WARRANT AND THE SHARES ISSUABLE HEREUNDER HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE “ACT”), OR ANY APPLICABLE STATE SECURITIES LAWS, AND MAY NOT BE SOLD, PLEDGED OR OTHERWISE TRANSFERRED WITHOUT AN EFFECTIVE REGISTRATION THEREOF UNDER THE ACT AND ANY APPLICABLE STATE SECURITIES LAWS, OR PURSUANT TO RULE 144 OR AN EXEMPTION FROM THE REGISTRATION REQUIREMENTS OF THE ACT AND ANY APPLICABLE STATE SECURITIES LAWS.

AMENDMENT TO COMMON STOCK PURCHASE WARRANT OF ARTES MEDICAL, INC. (Issued in Connection with Bridge Loan 2004)
Common Stock Purchase • November 27th, 2006 • Artes Medical Inc • Pharmaceutical preparations • California

This Amendment dated as of June 23, 2006 (this “Amendment”), to each of the Common Stock Purchase Warrants (each, a “Warrant” and collectively, the “Warrants”) for the purchase of shares of Common Stock of Artes Medical, Inc. (the “Company”) listed on Exhibit A hereto, is made by and between the Company and each of the holders of one or more Warrants listed on Exhibit A (each, a “Holder” and collectively, the “Holders”).

SEPARATION AGREEMENT AND GENERAL RELEASE
Voting Agreement • November 27th, 2006 • Artes Medical Inc • Pharmaceutical preparations • California

This Separation Agreement and General Release (this “Agreement”) is made and entered into by and between Stefan M. Lemperle, M.D., a resident of the State of California (“Dr. Lemperle”), and Artes Medical, Inc., a Delaware corporation (the “Company”), and inures to the benefit of each of the Company’s current, former and future parents, subsidiaries, related entities, employee benefit plans and each of their respective fiduciaries, predecessors, successors, officers, directors, stockholders, agents, attorneys, employees and assigns.

AMENDMENT TO COMMON STOCK PURCHASE WARRANT OF ARTES MEDICAL, INC. (Issued in Connection with Series D Financing)
Common Stock Purchase • November 27th, 2006 • Artes Medical Inc • Pharmaceutical preparations • California

This Amendment dated as of June 23, 2006 (this “Amendment”), to each of the Common Stock Purchase Warrants (each, a “Warrant” and collectively, the “Warrants”) for the purchase of shares of Common Stock of Artes Medical, Inc. (the “Company”) listed on Exhibit A hereto, is made by and between the Company and each of the holders of one or more Warrants listed on Exhibit A (each, a “Holder” and collectively, the “Holders”).

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