0000912057-13-000005 Sample Contracts

DATED 11 July 2012 SERVICE AGREEMENT Mayer Brown International LLP
Service Agreement • January 17th, 2013 • Gw Pharmaceuticals PLC • Pharmaceutical preparations
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DEVELOPMENT AND LICENSE AGREEMENT between GW PHARMA LTD and GW PHARMACEUTICALS PLC and OTSUKA PHARMACEUTICAL CO., LTD dated as of February 14, 2007
Development and License Agreement • January 17th, 2013 • Gw Pharmaceuticals PLC • Pharmaceutical preparations • New York

THIS DEVELOPMENT AND LICENSE AGREEMENT (the “Agreement”) is entered into as of February 14, 2007, by and among GW PHARMA LTD, a company organized under the laws of England, having offices at Porton Down Science Park, Salisbury, Wiltshire, SP4 0JQ, United Kingdom, on behalf of itself and its Affiliates (collectively, “GW Pharma”), GW PHARMACEUTICALS PLC, a company organized under the laws of England, having offices at Porton Down Science Park, Salisbury, Wiltshire, SP4 0JQ, United Kingdom and OTSUKA PHARMACEUTICAL CO., LTD., a Japan corporation, having offices at 2-9, Kanda-Tsukasamachi, Chiyoda-ku, Tokyo, 101-8535, Japan (“Otsuka”). GW Pharma and Otsuka may be referred to herein individually as a “Party” or collectively as the “Parties.”

PRODUCT COMMERCIALISATION AND SUPPLY CONSOLIDATED AGREEMENT
Consolidated Agreement • January 17th, 2013 • Gw Pharmaceuticals PLC • Pharmaceutical preparations • England
BAYER AG and GW PHARMA LTD
Supply Agreement • January 17th, 2013 • Gw Pharmaceuticals PLC • Pharmaceutical preparations • England

THIS SUPPLY AGREEMENT (“Agreement”) is made the 20th day of May 2003 between BAYER AG, Bayer HealthCare, Division Pharma, having its registered office at Bayerwerk, 51368 Leverkusen, Germany (“Bayer”) and GW PHARMA LIMITED having its registered office at Porton Down Science Park, Salisbury, Wiltshire SP4 0JQ (“GW”).

DISTRIBUTION AND LICENSE AGREEMENT BY AND BETWEEN GW PHARMA LTD AND NOVARTIS PHARMA AG
Distribution and License Agreement • January 17th, 2013 • Gw Pharmaceuticals PLC • Pharmaceutical preparations • New York

This Distribution Agreement (“Agreement”) is entered into as of 8th April 2011 (“Effective Date”) by and between GW Pharma Ltd, a company incorporated under the laws of England and Wales (Company No. 03704998), whose registered office is at Porton Down Science Park, Wiltshire SP4 03Q (hereinafter referred to as “GW”) and Novartis Pharma AG, a company incorporated under the laws of Switzerland, with a place of business at Lichtstrasse 35, Basel, CH-4002 Switzerland, (hereinafter referred to as “Novartis”). GW and Novartis may hereinafter be referred to individually as a “Party” and collectively as the “Parties”.

AMENDMENT NUMBER 2 TO THE LICENSE AND DISTRIBUTION AGREEMENT
License and Distribution Agreement • January 17th, 2013 • Gw Pharmaceuticals PLC • Pharmaceutical preparations

between GW PHARMA LIMITED (“GW”) having its registered office at Porton Down Science Park, Salisbury, Wiltshire SP4 0JQ and BAYER HEALTHCARE AG, Division Pharma, having its registered office at Bayerwerk, 51368 Leverkusen, Germany (“Bayer”)

AMENDMENT NUMBER 4 TO THE LICENSE AND DISTRIBUTION AGREEMENT
License and Distribution Agreement • January 17th, 2013 • Gw Pharmaceuticals PLC • Pharmaceutical preparations

between GW PHARMA LIMITED (“GW”) having its registered office at Porton Down Science Park, Salisbury, Wiltshire SP4 0JQ and BAYER HEALTHCARE AG, Division Pharma, having its registered office at Bayerwerk, 51368 Leverkusen, Germany (“Bayer”)

GW PHARMA LTD and OTSUKA PHARMACEUTICAL CO., LTD AMENDMENT NO.2 TO RESEARCH COLLABORATION AND LICENCE AGREEMENT DATED JULY 9, 2007
Amendment Agreement • January 17th, 2013 • Gw Pharmaceuticals PLC • Pharmaceutical preparations • New York

*** Portions of this page have been omitted pursuant to a request for Confidential Treatment and filed separately with the Commission.

and *** - and - GW RESEARCH LIMITED - and - GW PHARMACEUTICALS PLC AGREEMENT FOR LEASE - relating to -
Agreement for Lease • January 17th, 2013 • Gw Pharmaceuticals PLC • Pharmaceutical preparations • England
Dated July 23, 2010
Amendment Agreement • January 17th, 2013 • Gw Pharmaceuticals PLC • Pharmaceutical preparations
MANUFACTURING AND SUPPLY AGREEMENT effective as of this 9 day of November, 2011 (the “Effective Date”), by and between NOVARTIS PHARMA AG Lichtstr. 35 CH-4056 Basel Switzerland (hereinafter “NOVARTIS”) and GW Pharma Ltd Porton Down Science Park...
Manufacturing and Supply Agreement • January 17th, 2013 • Gw Pharmaceuticals PLC • Pharmaceutical preparations • New York

WHEREAS, GW is a company engaged in the processing and supply of pharmaceutical products holding the necessary manufacturing licenses and permits in this respect;

AMENDMENT NUMBER 3 TO THE LICENSE AND DISTRIBUTION AGREEMENT
License and Distribution Agreement • January 17th, 2013 • Gw Pharmaceuticals PLC • Pharmaceutical preparations

between GW PHARMA LIMITED (“GW”) having its registered office at Porton Down Science Park, Salisbury, Wiltshire SP4 OJQ and BAYER HEALTHCARE AG, Division Pharma, having its registered office at Bayerwerk, 51368 Leverkusen, Germany (“Bayer”)

and - GW PHARMA LIMITED TENANCY AGREEMENT - relating to - Hogan Lovells Ref: CM1 /SRlMFS/2523758 Hogan Lovells International LLP, Atlantic House, Holborn Viaduct, London EC1A 2FG
Tenancy Agreement • January 17th, 2013 • Gw Pharmaceuticals PLC • Pharmaceutical preparations

*** Portions of this page have been omitted pursuant to a request for Confidential Treatment and filed separately with the Commission.

GW PHARMA LTD and OTSUKA PHARMACEUTICAL CO., LTD AMENDMENT NO.1 TO RESEARCH COLLABORATION AND LICENCE AGREEMENT DATED JULY 9, 2007
Agreement • January 17th, 2013 • Gw Pharmaceuticals PLC • Pharmaceutical preparations • New York

*** Portions of this page have been omitted pursuant to a request for Confidential Treatment and filed separately with the Commission.

BAYER AG and GW PHARMA LTD LICENSE AND DISTRIBUTION AGREEMENT
License and Distribution Agreement • January 17th, 2013 • Gw Pharmaceuticals PLC • Pharmaceutical preparations

THIS LICENSE AND DISTRIBUTION AGREEMENT (hereinafter “Agreement”), is made as of the 20th day of May 2003, between GW PHARMA LIMITED (“GW”) having its registered office at Porton Down Science Park, Salisbury, Wiltshire SP4 0JQ and BAYER AG, Bayer HealthCare, Division Pharma, having its registered office at Bayerwerk, 51368 Leverkusen, Germany (“Bayer”).

AMENDMENT NUMBER 1 TO THE LICENSE AND DISTRIBUTION AGREEMENT
License and Distribution Agreement • January 17th, 2013 • Gw Pharmaceuticals PLC • Pharmaceutical preparations

between GW PHARMA LIMITED (“GW”) having its registered office at Porton Down Science Park, Salisbury, Wiltshire SP4 0JQ and BAYER HEALTHCARE AG, Division Pharma, having its registered office at Bayerwerk, 51368 Leverkusen, Germany (“Bayer”)

AMENDMENT NO. 1 TO THE DEVELOPMENT AND LICENSE AGREEMENT between GW PHARMA LTD and OTSUKA PHARMACEUTICAL CO., LTD and GW PHARMACEUTICALS PLC
Development and License Agreement • January 17th, 2013 • Gw Pharmaceuticals PLC • Pharmaceutical preparations • New York

THIS AMENDMENT NO. 1 (“Amendment”) to that certain Development and License Agreement dated February 14, 2007 by and among the parties hereto (“Agreement”), is made and entered into as of November 1, 2008 (“Amendment Effective Date”), by and among GW Pharma Ltd a corporation organized and existing under the laws of England having offices at Porton Down Science Park, Salisbury, Wiltshire, SP4 OJQ, United Kingdom on behalf of itself and its Affiliates (collectively “GW Pharma”), GW Pharmaceuticals Plc, a company organized under the laws of England, having offices at Porton Down Science Park, Salisbury, Wiltshire, SP4 OJQ, United Kingdom and Otsuka Pharmaceutical Co., Ltd., a corporation organized and existing under the laws of Japan, having a principal place of business at 2-9, Kanda Tsukasamachi, Chiyoda-ku, Tokyo, 101-8535 Japan (“Otsuka”).

GW PHARMA LTD and ALMIRALL, S.A. SUPPLEMENTARY AGREEMENT TO THE PRODUCT COMMERCIALISATION AND SUPPLY CONSOLIDATED AGREEMENT DATED 6TH JUNE, 2006
Supplementary Agreement • January 17th, 2013 • Gw Pharmaceuticals PLC • Pharmaceutical preparations
AMENDMENT NUMBER 1 TO THE SUPPLY AGREEMENT
Supply Agreement • January 17th, 2013 • Gw Pharmaceuticals PLC • Pharmaceutical preparations

between GW PHARMA LIMITED (“GW”) having its registered office at Porton Down Science Park, Salisbury, Wiltshire SP4 0JQ and BAYER HEALTHCARE AG, Division Pharma, having its registered office at Bayerwerk, 51368 Leverkusen, Germany (“Bayer”)

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AMENDMENT NUMBER 2 TO THE SUPPLY AGREEMENT
Supply Agreement • January 17th, 2013 • Gw Pharmaceuticals PLC • Pharmaceutical preparations

between GW PHARMA LIMITED (“GW”) having its registered office at Porton Down Science Park, Salisbury, Wiltshire SP4 OJQ and BAYER HEALTHCARE AG, Division Pharma, having its registered office at Bayerwerk, 51368 Leverkusen, Germany (“Bayer”)

Amendment # 5
Gw Pharmaceuticals PLC • January 17th, 2013 • Pharmaceutical preparations

to the License and Distribution Agreement by and between Bayer Schering Pharma AG (formerly “Bayer AG, Bayer HealthCare, Division Pharma”) and GW Pharma Limited dated May 20, 2003 — hereinafter referred to as “Distribution Agreement” —

Amendment # 3
Gw Pharmaceuticals PLC • January 17th, 2013 • Pharmaceutical preparations

to the Supply Agreement by and between Bayer Schering Pharma AG (formerly “Bayer AG, Bayer HealthCare, Division Pharma”) and GW Pharma Limited dated May 20, 2003 — hereinafter referred to as “Supply Agreement” —

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