0000899866-15-000080 Sample Contracts

AMENDMENT NO. 5 TO RIGHTS AGREEMENT
Rights Agreement • March 16th, 2015 • Alexion Pharmaceuticals Inc • Pharmaceutical preparations • Delaware

This Amendment No. 5 (this "Amendment") is made as of March 16, 2015 to the Rights Agreement, dated as of February 14, 1997, by and between Alexion Pharmaceuticals, Inc., a Delaware corporation (the "Company"), and Computershare Trust Company, N.A. (as successor rights agent to Continental Stock Transfer & Trust Company) (the "Rights Agent"), as amended by Amendment No. 1 thereto, dated as of September 18, 2000, Amendment No. 2 thereto, dated as of December 12, 2001, Amendment No. 3 thereto, dated as of November 16, 2004 and Amendment No. 4 dated as of February 23, 2007 (collectively, the "Rights Agreement").

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