0000893220-06-002385 Sample Contracts

INVESTMENT AND SHAREHOLDERS’ AGREEMENT Spepharm Holding B.V. by and among
Investment and Shareholders’ Agreement • November 9th, 2006 • Valera Pharmaceuticals Inc • Pharmaceutical preparations
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LICENSE AND DISTRIBUTION AGREEMENT
License and Distribution Agreement • November 9th, 2006 • Valera Pharmaceuticals Inc • Pharmaceutical preparations • New York

THIS LICENSE AND DISTRIBUTION AGREEMENT is entered into as of the 27 day of September 2006, by and between VALERA PHARMACEUTICALS, INC., a corporation incorporated under the laws of the state of Delaware with its principal place of business located at 7 Clarke Drive, Cranbury, New Jersey 08512-3617 USA (“Valera”), and SPEPHARM HOLDINGB.V., a corporation incorporated under the laws of the Netherlands with its principal place ofbusiness located in Amsterdam, the Netherlands (“Spepharm”).

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