0000318771-06-000005 Sample Contracts

FIRST AMENDMENT TO THE TOLL MANUFACTURING AGREEMENT DATED SEPTEMBER 15, 2004 BETWEEN GENENTECH, INC. AND WYETH
Toll Manufacturing Agreement • February 17th, 2006 • Genentech Inc • Pharmaceutical preparations

This amendment (the “Amendment”), effective as of December 8, 2004, is made by and between Genentech, Inc., a Delaware corporation having a principal place of business at 1 DNA Way, South San Francisco, California 94080 (“Genentech”), and Wyeth, a Delaware corporation acting through its Wyeth Pharmaceuticals Division having its principal place of business at Five Giralda Farms, Madison, New Jersey 07940 (“Wyeth”). Wyeth and Genentech are referred to herein collectively as the “Parties.”

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FIRST AMENDMENT TO TRANSITION AGREEMENT
Transition Agreement • February 17th, 2006 • Genentech Inc • Pharmaceutical preparations

This First Amendment to the Agreement may be executed in separate counterparts that together constitute one instrument.

FIRST AMENDMENT TO THE MANUFACTURING AND SUPPLY AGREEMENT DATED DECEMBER 7 2003
Manufacturing and Supply Agreement • February 17th, 2006 • Genentech Inc • Pharmaceutical preparations

THIS FIRST AMENDMENT TO THE MANUFACTURING AND SUPPLY AGREEMENT DATED DECEMBER 7 2003 ("Amendment") is made effective as of 14 March 2005 (the “Effective Date”), by and between Lonza Biologics PLC, having its principal place of business at 228 Bath Road, Slough, Berkshire SL1 4DX, England ("LB"), Lonza Biologics, Inc. having its principal place of business at 101 International Drive Portsmouth, New Hampshire 03801 ("Lonza Inc") (collectively LB and Lonza Inc, hereinafter "Lonza"), and Genentech, Inc., a Delaware corporation, having its principal place of business at One DNA Way, South San Francisco, California 94080 ("Genentech").

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