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Trial Agreement • February 7th, 2018

CLINICAL TRIAL AGREEMENT SMLOUVA O KLINICKÉM HODNOCENÍ Protocol #xxxxx Protokol číslo xxxxxx This Clinical Trial Agreement (“Agreement”) dated as of the date of last signature and effective as of publication of this Agreement in Agreement Registry (“Effective Date”) between Tato smlouva o klinickém hodnocení (dále jen “smlouva”) ze dne připojení posledního podpisu s účinností k datu uveřejnění smlouvy v Registru smluv (dále jen “datum účinnosti”) se uzavírá mezi Amryt Research Ltd., xxxxxx (“Sponsor”) Amryt Research Ltd. xxxxx (dále jen “zadavatel”). and a University Hospital Brno, with a place of business at Jihlavská 20, 625 00 Brno, Czech Republic, ID number: 65269705, VAT: CZ65269705, represented by: MUDr. Roman Kraus, MBA, Director, state-funded organization established by the decision of the Ministry of Health, without duty of registration in the commercial register, registered in the Trade Register kept by the Municipal Trade Office in Brno (“Institution”) Fakultní nemocnice Brn

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