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Trial Agreement • July 26th, 2018

Smlouva o sponzorovaném klinickém hodnocení A Phase 3, Multicenter, Randomized, Double-blind, Double-dummy, Active- controlled Study to Assess the Efficacy and Safety of Maribavir Compared to Valganciclovir for the Treatmentof Cytomegalovirus (CMV) Infection in Hematopoietic Stem Cell Transplant Recipients Shire ViroPharma, IncorporatedKlinický protokol č. SHP620-302 Sponsored Clinical Trial Agreement A Phase 3, Multicenter, Randomized, Double-blind, Double-dummy, Active- controlled Study to Assess the Efficacy and Safety of Maribavir Compared to Valganciclovir for the Treatmentof Cytomegalovirus (CMV) Infection in Hematopoietic Stem Cell Transplant Recipients Shire ViroPharma, Incorporated Clinical Protocol No. SHP620-302 TATO SMLOUVA O SPONZOROVANÉM KLINICKÉMHODNOCENÍ („Smlouva“) je uzavřena k datu posledního podpisu („Datum účinnosti“) mezi společností Shire Human Genetic Therapies, Inc. (jako pobočky Shire ViroPharma, Incorporated), se sídlem v 300 Shire Way, Lexington, MA 02421 US

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