Common Contracts

Execution Copy SECOND AMENDED AND RESTATED RESEARCH AND LICENSE AGREEMENT between FOVEA PHARMACEUTICALS SA and COMBINATORX, INCORPORATED Dated July 22, 2009

Research and License Agreement • July 23rd, 2009 • Combinatorx, Inc • Pharmaceutical preparations • New York

• Contract Type
  Research and License Agreement
• Filed
  July 23rd, 2009
• Company
  Combinatorx, Inc
• Industry
  Pharmaceutical preparations
• Jurisdiction
  New York

This Second Amended and Restated Research and License Agreement (the “Agreement”) is dated as of July 22, 2009 (the “Effective Date”) and is between Fovea Pharmaceuticals SA, a company organized and existing under the laws of, France, with an office at Institut de la Vision, 1 rue Moreau 75012 Paris, France (“Fovea”), and CombinatoRx, Incorporated, a company organized and existing under the laws of Delaware, with an office at 245 First Street, Cambridge, MA 02142 (“CombinatoRx”) and amends and restates in its entirety the Amended and Restated Research and License Agreement between Fovea and CombinatoRx (the "Amended and Restated Agreement") dated as of June 12, 2007 (the "Amended and Restated Agreement Effective Date"). Each of Fovea and CombinatoRx are sometimes referred to herein as a “Party” and together as the “Parties.”

CONFIDENTIAL Execution Copy AMENDED AND RESTATED RESEARCH AND LICENSE AGREEMENT between FOVEA PHARMACEUTICALS SA and COMBINATORX, INCORPORATED Dated June 12, 2007

Research and License Agreement • June 12th, 2007 • Combinatorx, Inc • Pharmaceutical preparations • New York

• Contract Type
  Research and License Agreement
• Filed
  June 12th, 2007
• Company
  Combinatorx, Inc
• Industry
  Pharmaceutical preparations
• Jurisdiction
  New York

This Amended and Restated Research and License Agreement (the “Agreement”) is dated as of June 12, 2007 (the “Effective Date”) and is between Fovea Pharmaceuticals SA, a company organized and existing under the laws of, France, with an office at 12, rue Jean-antione de Baif 75013 Paris, France (“Fovea”), and CombinatoRx, Incorporated, a company organized and existing under the laws of Delaware, with an office at 245 First Street, Cambridge, MA 02142 (“CombinatoRx”) and amends and restates in its entirety the Research and License Agreement between Fovea and CombinatoRx (the "Original Agreement") dated as of January 30, 2006 (the "Original Agreement Effective Date"). Each of Fovea and CombinatoRx are sometimes referred to herein as a “Party” and together as the “Parties.”