Exhibit 10.2
SHAREHOLDER AGREEMENT
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SHAREHOLDER AGREEMENT (this "Agreement"), dated as of July 26, 1999 by
and between Yamanouchi Group Holdings Inc. ("Shareholder"), and Shire
Pharmaceuticals Group plc, a public limited company organized under the laws of
England and Wales ("Shire").
WHEREAS, concurrently herewith, Ruby Acquisition Sub Inc., Shire and
Xxxxxxx Pharmaceutical Corporation, a New Jersey corporation ("Xxxxxxx"), are
entering into an Agreement and Plan of Merger of even date herewith (such
Agreement in the form attached hereto as Exhibit A as it may be subsequently
amended or modified (other than a reduction in the Merger Consideration (as
defined therein)) being the "Merger Agreement"), pursuant to which a newly
formed, wholly owned subsidiary of Shire will merge with and into Xxxxxxx (the
"Merger"); and
WHEREAS, Shareholder owns, as of the date hereof, 5,048,500 shares of
common stock, $.01 par value per share (the "Common Stock") of Xxxxxxx (the
"Existing Shares", together with any shares of Common Stock acquired after the
date hereof and prior to the termination hereof, hereinafter collectively
referred to as the "Shares"); and
WHEREAS, Shire has entered into the Merger Agreement in reliance on
Shareholder's representations, warranties, covenants and agreements set forth
herein and Shareholder has entered into the Agreement in reliance on Shire's
representations, warranties, covenants and agreements set forth herein.
NOW, THEREFORE, in consideration of the mutual covenants and
agreements herein contained and other good and valuable consideration, and
intending to be legally bound hereby, it is agreed as follows:
1. Voting Agreement. Shareholder agrees to vote and otherwise act (including
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pursuant to written consent) with respect to all of the Shares, for the approval
and the adoption of the Merger Agreement, all agreements related to the Merger
and any actions required to be approved by shareholders related thereto, and
against any proposal or transaction which could prevent or delay the
consummation of the transactions contemplated by the Merger Agreement, at any
meeting or meetings of
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the shareholders of Xxxxxxx, and at any adjournment, postponement or
continuation thereof, at which the Merger Agreement and other related agreements
(or any amended version or versions thereof), or such other actions are
submitted for the consideration and vote of the shareholders of Xxxxxxx. The
foregoing shall remain in effect with respect to the Shares, until the
termination of this Section as set forth in Section 7. Shareholder agrees to
cause a duly authorized representative of Shareholder to attend any meeting or
meetings of the shareholders to which this Section 1 applies, either in person
or by proxy, and to vote the Shares in accordance with the terms hereof.
2. Representations and Warranties of Shareholder. Shareholder represents and
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warrants to Shire as follows:
2.1 Ownership of Shares. On the date hereof the Existing Shares are
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all of the Shares currently beneficially owned by Shareholder. On the Closing
Date, the Shares will constitute all of the shares of Common Stock owned
beneficially by Shareholder. Shareholder has no rights to acquire any
additional shares of Common Stock other than under the terms of the Stock
Purchase Agreement between the Shareholder and Xxxxxxx, dated as of January 22,
1992 and other than for the Shareholder's right of first refusal granted under
its agreement with Xxxxxx Xxxxxxxx.
2.2 Authority; Binding Agreement. Shareholder has the full legal
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right, power and authority to enter into and perform all of its obligations
under this Agreement. The execution and delivery of this Agreement by
Shareholder will not violate any other agreement to which Shareholder is a party
including, without limitation, any voting agreement, shareholders agreement or
voting trust. This Agreement has been duly executed and delivered by
Shareholder and constitutes a legal, valid and binding agreement of Shareholder,
enforceable in accordance with its terms, except as the enforcement thereof may
be limited by bankruptcy, insolvency, reorganization, moratorium and similar
laws, now or hereafter in effect affecting creditors' rights and remedies
generally or general principles of equity. Neither the execution and delivery
of this Agreement nor the consummation by Shareholder of the transactions
contemplated hereby will (i) violate, or require any consent, approval or notice
under, any provision of any judgment, order, decree, statute, law, rule or
regulation applicable to Shareholder
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or the Shares, (ii) constitute a violation of, conflict with or constitute a
default under, any material contract, commitment, agreement, understanding,
arrangement or other restriction of any kind to which Shareholder is a party or
by which Shareholder is bound.
2.3 Reliance on Agreement. Shareholder understands and acknowledges
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that Shire is entering into the Merger Agreement in reliance upon Shareholder's
execution and delivery of this Agreement.
3. Certain Covenants of Shareholder. Except in accordance with the provisions
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of this Agreement, Shareholder agrees with, and covenants to, Shire as follows:
3.1 Actions Inconsistent with this Agreement. For so long as
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Shareholder is obligated to vote in favor of the Merger set forth in Section 1,
Shareholder shall not (i) transfer (which term shall include, without
limitation, for the purposes of this Agreement, any sale, gift, pledge,
assignment, encumbrance or other disposition), or consent to any transfer of,
any or all of the Shares or any interest therein, except pursuant to the Merger
or (ii) enter into any contract, option or other agreement or understanding with
respect to any transfer of any or all such Shares or any interest therein
unless, in either case, (x) the transferee of such Shares is an affiliate of
such Shareholder or is otherwise reasonably acceptable to Shire and such
transferee agrees, in a writing reasonably acceptable to Shire, to vote such
Shares in accordance with the terms of Section 1 as if such transferee were the
Shareholder and (y) such transaction does not occur within 30 days as of the
Effective Time. In addition, until Section 1 has terminated in accordance with
paragraph 7, Shareholder shall not grant any proxy, power-of-attorney or other
authorizations in or with respect to such Shares or deposit such Shares into a
voting trust or enter into a voting agreement or arrangement with respect to the
Shares in any way inconsistent with the terms of this Agreement.
3.2 Solicitation. Until consummation of the Merger, Shareholder
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shall not, and shall direct their investment bankers, attorneys or other
advisers or representatives not to, directly or indirectly, (i) solicit or
initiate (including by way of furnishing or disclosing non-public information)
any inquiries or the making of any proposal with respect to a Xxxxxxx
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Acquisition Transaction (as defined in the Merger Agreement) or (ii) negotiate,
explore or otherwise engage in discussions with any person (other than Shire and
its representatives) with respect to any Xxxxxxx Acquisition Transaction, or
which may reasonably be expected to lead to a proposal for a Xxxxxxx Acquisition
Transaction or enter into any agreement, arrangement or understanding with
respect to any such Xxxxxxx Acquisition Transaction or which would require it to
abandon, terminate or fail to consummate the Merger or any other transaction
contemplated by this Agreement; provided, however, that Shareholder may, in
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response to an unsolicited written proposal from a third party regarding a
Xxxxxxx Superior Proposal (as defined in the Merger Agreement), furnish
information to, negotiate or otherwise engage in discussions with such third
party, if the Board of Directors of Xxxxxxx determines in good faith, after
consultation with its financial advisors and based upon advice of outside
counsel that such action is required for the Board of Directors to comply with
its fiduciary duties under applicable law.
3.3 Holdback Agreement. Unless the managing underwriter otherwise
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agrees, Shareholder agrees to use its reasonable best efforts to cause its
affiliates to agree, in connection with any underwritten registration of Shire
ordinary shares, nominal value five xxxxx (the "Ordinary Shares"), not to effect
any public sale or private offer or distribution of any Ordinary Shares, or
American Depositary Shares representing three Ordinary Shares (the "Shire ADSs")
during the ten business days prior to the effectiveness under the Securities Act
of any underwritten registration and during the 90 days following the
effectiveness under the Securities Act of 1933, as amended (the "Securities
Act") of any underwritten registration (except, if applicable, as part of such
underwritten registration).
3.4 Shareholder shall not reduce its risk relative to any Ordinary
Shares or Shire ADSs (each as defined in the Merger Agreement) received in the
Merger as a result of its ownership of the Shares prior to the publication of
not less than 30 days of financial results covering the post-Merger combined
operations of Shire and Xxxxxxx. Shire will cause such results to be published
as soon as reasonably practicable after the Effective Time under the Merger
Agreement.
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4. Representations and Warranties of Shire. Shire represents and warrants to
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Shareholder as follows:
Shire has full legal right, power and authority to enter into and
perform all of its obligations under this Agreement. The execution and delivery
of this Agreement by Shire will not violate any other agreement to which Shire
is a party. This Agreement has been duly executed and delivered by Shire and
constitutes a legal, valid and binding agreement of Shire, enforceable in
accordance with its terms, except as the enforcement thereof may be limited by
bankruptcy, insolvency, reorganization, moratorium and similar laws, now or
hereafter in effect, affecting creditors rights and remedies generally or
general principles of equity. Neither the execution and delivery of this
Agreement nor the consummation by Shire of the transactions contemplated hereby
will (i) violate, or require any consent, approval or notice under, any
provision of any judgment, order, decree, statute, law, rule or regulation
applicable to Shire or the Shares, except for the action contemplated by Section
5.2, or (ii) constitute a violation of, conflict with or constitute a default
under, any contract, commitment, agreement, understanding, arrangement or other
restriction of any kind to which Shire is a party or by which it is bound.
5. Certain Covenants of Shire. Shire represents and warrants to Shareholder as
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follows:
5.1 Without the consent of Shareholder, Shire will not, prior to the
second anniversary of the Closing Date (as defined in the Merger Agreement), (i)
dispose of any of its stock in the Surviving Corporation or (ii) permit the
Surviving Corporation to dispose of substantially all of its assets.
Thereafter, until the fifth anniversary of the Closing Date, to the extent
permitted by applicable law, Shire will give Shareholder not less than 60 days
written notice of its intention to engage in a transaction described in clause
(i) or (ii) of the preceding sentence.
5.2 Registration Rights of Shareholder.
(a) Shelf Registration. Promptly following the Effective Time (as
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defined in the Merger Agreement), Shire shall commence the registration of
Shareholder's Shire ADSs received in the Merger (collectively the "Registrable
Securities") on
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Form S-3 for an offering pursuant to Rule 415 promulgated by the Securities and
Exchange Commission (the "SEC"). Such registration statement may include Shire
ADSs received by other Xxxxxxx shareholders in the Merger. Any such shelf
registration shall cover the disposition of all Registrable Securities and such
other Shire ADSs in one or more underwritten offerings, block transactions,
broker transactions, at-market transactions and in such other manner or manners
as may be specified by the Shareholder. Shire shall use its reasonable best
efforts to cause such registration statement to become effective within 180 days
of the Effective Time and keep such registration continuously effective until
the second anniversary of the Closing Date. In furtherance of such obligation,
Shire shall supplement or amend such registration statement if, as and when
required by the rules, regulations and instructions applicable to the form used
by Shire for such registration or by the Securities Act or by any other rules
and regulations thereunder applicable to shelf registrations. Notwithstanding
the foregoing, it shall not be deemed a violation of this paragraph if pending a
material corporate transaction, Shire issues a notice that the registration
statement, or the prospectus contained therein, is unusable (as not being
current as to disclosure), or such notice is required under applicable
securities laws to be issued by Shire, and the aggregate number of days in any
consecutive twelve month period for which the registration statement, or the
prospectus contained therein, is unusable pursuant to all such notices has not
exceeded 90 days in the aggregate.
(b) Issuer Registration. If Shire shall determine to register any
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Shire ADSs either for its own account or the account of a security holder or
holders other than a registration relating solely with respect to employee
benefit plans, or a registration relating to paragraph (a) above, a registration
on any registration form which does not permit secondary sales, Shire will:
(i) promptly give to the Shareholder written notice thereof; and
(ii) include in such registration statement all Registrable
Securities specified in a written request made by the Shareholder within
ten (10) days after receipt of the written notice from Shire described in
clause (i) above, except as set forth in paragraph (c) below. Such written
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request may specify all or part of the Shareholder's Registrable
Securities.
The right of the Shareholder to registration pursuant to this
paragraph (b) shall be conditioned upon the Shareholder's providing all
information required of a selling shareholder under the Securities Act. The
Shareholder shall, if it proposes to distribute its Registrable Securities
through such underwriting, enter into an underwritten offering in customary form
with the representative of the underwriter or underwriters selected by Shire.
(c) Priority. Notwithstanding the provisions of Section 5.2(b), if
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the representative of the underwriters advises Shire in writing that marketing
factors require a limitation or elimination on the number of shares to be
included in the offering covered by Section 5.2(b), the representative may
(subject to the allocation priority set forth below) limit the number of
Registrable Securities to be included in the registration statement. Shire
shall so advise all holders of securities requesting registration, and the
number of Shire ADSs that are entitled to be included in the registration
statement shall be allocated first to Shire for securities being sold for its
own account, and thereafter the number of Shire ADSs that may be included in the
registration statement shall be allocated among the Shareholder and other
shareholders of Shire in proportion, as nearly as practicable, to the respective
amounts of Shire ADSs which they had requested to be included in such
registration at the time of filing the registration statement. If the
Shareholder or any other shareholder disapproves of the terms of any such
underwriting, he may elect to withdraw therefrom by written notice to Shire and
the underwriter. Notwithstanding this clause (c), in any underwritten primary
offering for cash, Shire will ensure that Shareholder will be allowed to
participate in the offering to the extent of not less than 20% of the aggregate
number of Shire ADSs to be offered.
(d) Expenses of Registration. All Registration Expenses incurred in
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connection with any registration pursuant to this Section 5.2 shall be borne by
Shire and all Selling Expenses shall be borne by the holders of the securities
so registered pro rata on the basis of the number of their shares sold.
"Registration Expenses" shall mean all expenses incurred by Shire in connection
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with the registration rights granted hereunder, including, without limitation,
all registration and
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filing fees, printing expenses, fees and disbursements of counsel and the
expenses of any special audits incident to or required by any such registration.
"Selling Expenses" shall mean all underwriting discounts and commissions
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together with all expenses of the shareholder(s).
(e) Registration Procedures. In the case of each registration
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effected by Shire pursuant to this Section 5.2, Shire will keep the Shareholder
advised in writing as to the initiation of each registration and as to the
completion thereof. At its expense, Shire will:
(i) Prepare and file with the SEC such amendments and supplements
to such registration statement and the prospectus used in connection with
such registration statement as may be necessary to comply with the
provisions of the Securities Act with respect to the disposition of all
securities covered by such registration statement;
(ii) Furnish such number of prospectuses and other documents
incident thereto, including any amendment of or supplement to the
prospectus, as the Shareholder from time to time may reasonably request;
and
(iii) Notify the Shareholder at any time when a prospectus
relating thereto is required to be delivered under the Securities Act of
the happening of any event as a result of which the prospectus included in
such registration statement, as then in effect, includes an untrue
statement of a material fact or omits to state a material fact required to
be stated therein or necessary to make the statements therein not
misleading or incomplete in the light of the circumstances then existing,
and at the request of any such seller, prepare and furnish to the
Shareholder a reasonable number of copies of a supplement to or an
amendment of such prospectus as may be necessary so that, as thereafter
delivered to the purchasers of such shares, such prospectus shall not
include an untrue statement of a material fact or omit to state a material
fact required to be stated therein or necessary to make the statements
therein not misleading or incomplete in the light of the circumstances then
existing.
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(f) Cause all such Registrable Securities to be listed on each
securities exchange on which similar securities issued by Shire are then listed.
6. Indemnification.
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6.1 Shire will indemnify Shareholder, each of its officers, directors
and employees, and each Person who controls Shareholder within the meaning of
the Securities Act and the rules and regulations thereunder, with respect to
which registration has been effected pursuant to Section 5.2, against all
claims, losses, damages and liabilities (or actions, proceedings or settlements
in respect thereof) arising out of or based on any untrue statement (or alleged
untrue statement) of a material fact contained in any prospectus (including any
related registration statement) incident to any such registration, or based on
any omission (or alleged omission) to state therein a material fact required to
be stated therein or necessary to make the statements therein not misleading, or
any violation by Shire of the Securities Act or the Exchange Act or any rule or
regulation thereunder applicable to Shire and relating to action or inaction
required of Shire in connection with any such registration, and will reimburse
Shareholder, each of its officers, directors and employees, and each Person
controlling Shareholder, for any legal and any other expenses reasonably
incurred in connection with investigating and defending or settling any such
claim, loss, damage, liability or action, provided that Shire will not be liable
in any such case to the extent that any such claim, loss, damage, liability or
expense arises out of or is based on any untrue statement or omission based upon
written information furnished to Shire by Shareholder and stated to be
specifically for use therein, or in the case of a non-underwritten public
offering, the failure of Shareholder to deliver prospectuses as required by the
Securities Act.
6.2 Shareholder will, if Registrable Securities held by it are
included in the securities as to which such registration is being effected,
indemnify Shire, each of its officers, directors and employees, and each Person
who controls Shire within the meaning of the Securities Act and the rules and
regulations thereunder, against all claims, losses, damages and liabilities (or
actions, proceedings or settlements in respect thereof) arising out of or based
on any untrue statement (or alleged untrue statement) of a material fact
contained in any
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such registration statement or prospectus, or based on any omission (or alleged
omission) to state therein a material fact required to be stated therein or
necessary to make the statements therein not misleading, or any violation by
Shareholder of the Securities Act or the Exchange Act or any rule or regulation
thereunder applicable to Shareholder and relating to action or inaction required
of Shareholder in connection with any such registration, and will reimburse
Shire, each of its officers, directors and employees, and each Person who
controls Shire, for any legal or any other expenses reasonably incurred in
connection with investigating and defending or settling any such claim, loss,
damage, liability or action, in each case to the extent, but only to the extent,
that such untrue statement (or alleged untrue statement) or omission (or alleged
omission) is made in such registration statement or prospectus in reliance upon
and in conformity with written information furnished to Shire by Shareholder and
stated to be specifically for use therein; provided, however, that the
obligations of Shareholder hereunder shall be limited to an amount equal to the
proceeds to Shareholder of securities sold as contemplated herein.
6.3 Each party entitled to indemnification under this Section 6 (the
"Indemnified Party") shall give notice to the party required to provide
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indemnification (the "Indemnifying Party") promptly after such Indemnified Party
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has actual knowledge of any claim as to which indemnity may be sought, and shall
permit the Indemnifying Party to assume the defense of any such claim or any
litigation resulting therefrom, provided that counsel for the Indemnifying
Party, who shall conduct the defense of such claim or any litigation resulting
therefrom, shall be approved by the Indemnified Party (whose approval shall not
unreasonably be withheld), and the Indemnified Party may participate in such
defense at such party's expense, and provided further that the failure of any
Indemnified Party to give notice as provided herein shall not relieve the
Indemnifying Party of its obligations under this Section 6. No Indemnifying
Party, in the defense of any such claim or litigation, shall, except with the
consent of each Indemnified Party, consent to entry of any judgment or enter
into any settlement which does not include as an unconditional term thereof the
giving by the claimant or plaintiff to such Indemnified Party of a release from
all liability in respect to such claim or litigation. Each Indemnified Party
shall furnish such information regarding itself or the claim in question as an
Indemnifying
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Party may require in connection with defense of such claim and
litigation resulting therefrom.
7. Termination. Subject to the rights of the parties to pursue any claims
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arising out of breaches of representations, warranties, covenants and agreements
that occur prior to such termination, this Agreement shall terminate on the
earlier of (i) the termination of the Merger Agreement in accordance with its
terms, (ii) the second anniversary of the Closing Date (as defined in the Merger
Agreement), (iii) if the Merger Agreement is amended to decrease the Merger
Consideration (as defined in the Merger Agreement) per share and (iv) December
31, 1999 if the Effective Time has not occurred by such date. Section 1 hereof
will terminate upon the earlier of the termination of this Agreement in
accordance with the previous sentence or the Effective Time.
8. Miscellaneous.
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8.1 Survival of Representations and Warranties. All representations,
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warranties, covenants and agreements made in this Agreement shall survive the
date hereof and any investigation at any time made by or on behalf of any party.
8.2 Notices. All notices, requests, claims, demands and other
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communications under this Agreement shall be in writing and shall be delivered
personally or by next-day courier or telecopied with confirmation of receipt, to
the parties at the addresses specified below (or at such other address for a
party as shall be specified by like notice; provided that notices of a change of
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address shall be effective only upon receipt thereof). Any such notice shall be
effective upon receipt, if personally delivered or telecopied or one day after
delivery to a courier for next-day delivery.
If to Shire:
Shire Pharmaceuticals Group plc
Xxxx Xxxxx
Xxxxxxx, Xxxxx XX 00 0XX
Xxxxxx Xxxxxxx
Telecopy: 011 44 1 264 334 658
Attention: Xxxx Xxxxxx, Chief Executive
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with copies to:
Xxxx X. Xxxxxxxx, Esq.
Xxxxxx Xxxxxx & Xxxxxxx
00 Xxxx Xxxxxx
Xxx Xxxx, XX 00000
Telephone: (000) 000-0000
Telecopy: (000) 000-0000
If to Shareholder:
Xxxxx Xxxxxx
c/o Yamanouchi Pharmaceutical Co. Ltd.
0-00, Xxxxxxxxxx - Xxxxxx 0 - Xxxxx
Xxxx-xx, Xxxxx 000 Xxxxx
with a copy to:
Xxxxxxx X. Xxxxxx, Esq.
Howard, Rice, et al
Three Xxxxxxxxxxx Xxxxxx, 0xx Xxxxx
Xxx Xxxxxxxxx, XX 00000
Telephone: (000) 000-0000
Telecopy: (000) 000-0000
8.3 Entire Agreement. This Agreement, together with the documents
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expressly referred to herein, constitute the entire agreement and supersede all
other prior agreements and understandings, both written and oral, between the
parties, with respect to the subject matter contained herein.
8.4 Amendments. This Agreement may not be modified, amended, altered
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or supplemented, except upon the execution and delivery of a written agreement
executed by the parties hereto.
8.5 Assignment. This Agreement shall be binding upon and inure to
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the benefit of the parties hereto and their respective successors, assigns and
personal representatives, but, other than as contemplated by Section 3.1,
neither this Agreement nor any of the rights, interests or obligations hereunder
shall be assigned by any of the parties hereto without the prior written consent
of the other parties.
8.6 Public Announcements. Each of Shire and Shareholder agrees that
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it will not issue any press release or otherwise make any public statement with
respect to this Agreement,
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the Merger Agreement or the transactions contemplated hereby or thereby without
the prior consent of the other party, which consent shall not be unreasonably
withheld or delayed.
8.7 Governing Law. This Agreement, and all matters relating hereto,
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shall be governed by, and construed in accordance with the laws of the State of
New York without giving effect to the principles of conflicts of laws thereof.
8.8 Injunctive Relief; Jurisdiction. Shareholder agrees that
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irreparable damage would occur and that Shire would not have any adequate remedy
at law in the event that any of the provisions of this Agreement were not
performed in accordance with their specific terms or were otherwise breached.
It is accordingly agreed that Shire shall be entitled to an injunction or
injunctions to prevent breaches by Shareholder of this Agreement and to enforce
specifically the terms and provisions of this Agreement in any court of the
United States located in the State of New York, Borough of Manhattan, or in New
York state court located in the Borough of Manhattan, this being in addition to
any other remedy to which they are entitled at law or in equity. In addition,
each of the parties hereto (i) consents to submit such party to the personal
jurisdiction of any Federal court located in the State of New York, Borough of
Manhattan or in New York State Court located in the Borough of Manhattan in the
event any dispute arises out of this Agreement or any of the transactions
contemplated hereby, (ii) agrees that such party will not attempt to deny or
defeat such party to the personal jurisdiction by motion or other request for
leave from any such court and (iii) agrees that such party will not bring any
action relating to this Agreement or any of the transactions contemplated hereby
in any court other than a Federal or state court sitting in the State of New
York, located in the Borough of Manhattan.
8.9 Counterparts. This Agreement may be executed in any number of
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counterparts, each of which shall be deemed to be an original and all of which
together shall constitute one and the same document.
8.10 Descriptive Headings. The descriptive headings used herein are
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inserted for convenience of reference only and are not intended to be part of or
to affect the meaning or interpretation of this Agreement.
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8.11 Severability. Any term or provision of this Agreement which is
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invalid or unenforceable in any jurisdiction shall, as to such jurisdiction, be
ineffective to the extent of such invalidity or unenforceability without
rendering invalid or unenforceable the remaining terms and provisions of this
Agreement or affecting the validity or enforceability of any of the terms or
provisions of this Agreement in any other jurisdiction. If any provision of
this Agreement is so broad as to be unenforceable, such provision shall be
interpreted to be only so broad as is enforceable.
8.12 Further Assurances. Each party hereto shall execute and deliver
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such additional documents as may be necessary or desirable to consummate the
transactions contemplated by this Agreement.
8.13 Third-Party Beneficiaries. Otherwise than as contemplated by
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Section 3.1, nothing in this Agreement, expressed or implied, shall be construed
to give any person other than the parties hereto any legal or equitable right,
remedy or claim under or by reason of this Agreement or any provision contained
herein.
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IN WITNESS WHEREOF, Shire and Shareholder have caused this Agreement
to be executed by their duly authorized officers, as of the date and year first
above written.
SHIRE PHARMACEUTICALS GROUP PLC
By: \s\ Xxxx Xxxxxx
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Name: Xxxx Xxxxxx
Title: Chief Executive
YAMANOUCHI GROUP HOLDINGS INC.
By: \s\ Xxxxxxx Xxxxxxxxx
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Name: Xxxxxxx Xxxxxxxxx
Title: Manager
