Janus Letterhead ] March 18, 2013 Ms. Heidi W. Hardin Janus Capital Management LLC 151 Detroit Street Denver, Colorado 80206 Dear Ms. Hardin:

Exhibit (h)(181)

[ Janus Letterhead ]

March 18, 2013

Xx. Xxxxx X. Xxxxxx
Xxxxx Capital Management LLC
000 Xxxxxxx Xxxxxx
Xxxxxx, Xxxxxxxx 00000

Dear Xx. Xxxxxx:

Attached is revised Schedule A to the Administration Agreement dated June 23, 2011, as may be further amended from time to time (the “Agreement”), between Janus Investment Fund (the “Trust”) and Janus Capital Management LLC (“JCM”). The purpose of the revision is to reflect the termination and liquidation of Janus Global Research Fund, and the name change of Janus Worldwide Fund to Janus Global Research Fund, each effective as of March 18, 2013. Pursuant to Section 5 of the Agreement, the Trust hereby requests that JCM acknowledge its acceptance of the terms contained in the revised Schedule.

Please indicate your acceptance of the foregoing by executing two copies of this letter, returning one copy to the Trust and retaining one copy for your records.

JANUS INVESTMENT FUND
By:		/s/ Xxxxxxxxx Xxxxxxxxxx-Xxxxxx
Xxxxxxxxx Xxxxxxxxxx-Xxxxxx Vice President, Chief Legal Counsel and Secretary
JANUS CAPITAL MANAGEMENT LLC
By:		/s/ Xxxxx X. Xxxxxx
Xxxxx X. Xxxxxx
General Counsel and Senior Vice President

Revised effective as of March 18, 2013

SCHEDULE A

INTECH Global Dividend Fund
INTECH International Fund
INTECH U.S. Core Fund
INTECH U.S. Growth Fund

INTECH U.S. Value Fund
Janus Asia Equity Fund

Janus Balanced Fund
Janus Contrarian Fund

Janus Diversified Alternatives Fund
Janus Emerging Markets Fund

Janus Enterprise Fund
Janus Flexible Bond Fund

Xxxxx Xxxxx Fund
Janus Fund

Janus Global Bond Fund
Janus Global Life Sciences Fund

Janus Global Real Estate Fund
Janus Global Research Fund

Janus Global Select Fund
Janus Global Technology Fund

Janus Growth and Income Fund
Janus High-Yield Fund

Janus International Equity Fund
Janus Overseas Fund

Janus Protected Series — Global
Janus Protected Series — Growth

Janus Real Return Fund
Janus Research Fund

Janus Short-Term Bond Fund
Xxxxx Xxxxxx Fund

Xxxxx Twenty Fund
Janus Venture Fund

Janus World Allocation Fund
Xxxxxxx Global Value Fund

Xxxxxxx Large Cap Value Fund
Xxxxxxx Mid Cap Value Fund

Xxxxxxx Select Value Fund
Xxxxxxx Small Cap Value Fund

Xxxxxxx Value Plus Income Fund