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EXHIBIT 10.84
AMENDMENT NO. 2
TO
COLLABORATIVE RESEARCH AGREEMENT
BETWEEN SEQUANA THERAPEUTICS, INC.
AND
CORANGE INTERNATIONAL LTD.
DATED 30TH JUNE, 1995
This Amendment No. 2 (the "Amendment") to the Collaborative Research
Agreement entered into as of the 30th day of July, 1995, as amended by letter
dated January 9, 1998 (the "Original Agreement") is made by and between SEQUANA
THERAPEUTICS, INC., a California corporation, having its principal place of
business at 00000 Xxxxx Xxxxxx Xxxxx Xxxx, Xxxxx 000, Xx Xxxxx, Xxxxxxxxxx,
00000 ("Sequana") and CORANGE INTERNATIONAL LTD., a Bermuda corporation
("Corange") effective as of February 23, 1998.
WHEREAS, the Parties desire to amend the Original Agreement on the terms
provided below:
NOW, THEREFORE, in consideration of the foregoing premises and the mutual
premises and covenants set forth below, for other good and valuable
consideration the receipt and sufficiency of which the Parties acknowledge, the
Parties, intending to be legally bound, agree as follows:
1. Unless otherwise defined in this Amendment, the capitalized terms used in
this Amendment shall have the same meaning as given them in the Original
Agreement.
2. A new Section 1.4A shall be inserted as follows:
1.4A "Biomedical" means any research tool (including, without
limitation, probes, antibodies, conjugates or kits) for identifying
diagnostic markers for human disease, which tool is not subject to
regulation by the FDA and is not subject to regulation by any equivalent
agency to the FDA in a Major Country other than the United States of
America.
3. Section 1.12 shall be deleted in its entirety and the following Section
1.12 shall be inserted in lieu thereof:
1.12 "Diagnostic" means any Biomedical, diagnostic device, compound or
kit that is discovered, or the utility of which is discovered by Sequana or
Corange based on one or more Osteoporosis Gene(s) and that is covered by a
Corange Patent, Sequana Patent or Joint Patent anywhere in the world.
"Diagnostic" shall also include any service related to such a Diagnostic.
4. Section 2.3(iii) shall be deleted in its entirety and the following Section
2.3(iii) shall be inserted in lieu thereof:
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2.3(iii) [*]
5. Section 2.5 shall be deleted in its entirety and the following Section 2.5
shall be inserted in lieu thereof:
2.5 [*]
[*]
(iv) The JRMC shall stipulate in writing when each research
milestone has been achieved. In the event the JRMC cannot agree whether
a milestone has been achieved, the decision will be subject to the
resolution procedure of Article 3.3.
* Certain confidential information contained in the document, marked by
brackets, has been omitted and filed separately with the Securities and
Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of
1934, as amended.
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Except as modified above, the Original Agreement shall remain in full force
and effect.
IN WITNESS WHEREOF, the Parties hereto have executed this Agreement, the day and
year first above written.
SEQUANA THERAPEUTICS, INC. CORANGE INTERNATIONAL LTD
By: /s/ XXXXXX X. XXXXXX By: /s/ XXXXXX XXXXXXX
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Name: Xxxxxx X. Xxxxxx Name: Xx. XXXXXX XXXXXXX
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Title: President and COO Title: President and CEO
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BOEHRINGER MANNHEIM GMBH
By: /s/ XXXXXX XXXXXXXXXX
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Name: Xx. XXXXXX XXXXXXXXXX
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Title: Sr. V.P. R&D Therapeutics
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