EXHIBIT 10(bb)
ENZO DIAGNOSTICS, INC. - ▇▇▇▇▇▇ HEALTHCARE CORPORATION,
SCIENTIFIC PRODUCTS AND LIFESCIENCES DIVISION
DISTRIBUTORSHIP AGREEMENT
THIS AGREEMENT, effective upon acceptance by both parties below by and between
ENZO DIAGNOSTICS, INC. ("ENZO"), a New York corporation having its principal
place of business at ▇▇ ▇▇▇▇▇▇▇▇▇ ▇▇▇▇▇▇▇▇▇, ▇▇▇▇▇▇▇▇▇▇▇, ▇▇▇ ▇▇▇▇ ▇▇▇▇▇, and
the Scientific Products, Industrial and Lifesciences division of ▇▇▇▇▇▇
Healthcare Corporation ("BAXTER") a Delaware Corporation having its principal
place of business at ▇▇▇▇ ▇▇▇▇▇▇▇▇ ▇▇▇▇, ▇▇▇▇▇ ▇▇▇▇, ▇▇▇▇▇▇▇▇ ▇▇▇▇▇.
WHEREAS, ENZO owns rights to certain PATENTS listed in EXHIBIT A
("PATENTS");
WHEREAS ENZO manufactures and/or sells certain products covered by
claims of PATENTS which products are listed in EXHIBIT B hereto
("PRODUCTS");
WHEREAS BAXTER wishes to market and distribute some of said PRODUCTS
on a nonexclusive basis in accordance with the terms and conditions of
this Agreement;
NOW, THEREFORE, in consideration of the good and valuable mutual
agreements hereinafter set forth, the parties hereto agree as follows:
1. Distributor Appointment
ENZO hereby appoints BAXTER to act as its nonexclusive distributor
worldwide for the distribution and sale of PRODUCTS (EXHIBIT B), and BAXTER
agrees to act as such distributor under the terms and conditions set forth
herein.
BAXTER agrees:
a. not to purchase any PRODUCTS from other suppliers;
b. not to manufacture PRODUCTS;
c. to rely on ENZO as its sole source of PRODUCTS;
d. not to use any PRODUCT to manufacture new or other PRODUCTS;
e. that all PRODUCTS distributed by BAXTER are for research use only
and are not intended for or to be used for diagnostic or
therapeutic purposes; and
f. that except for DISTRIBUTION under the terms and conditions as
set forth in this AGREEMENT, purchase does not include any right
or license to exploit these PRODUCTS commercially, including any
right to sell these PRODUCTS to other distributors and that any
other commercial use or development of these PRODUCTS without the
express written authorization of ENZO is strictly prohibited.
Nothing herein creates or constitutes a partnership or an agreement of
agency between the parties with respect to any activities whatsoever. The
relationship between ENZO and BAXTER shall be that of seller and buyer, and
neither party shall conclude any contract or agreement or make any
commitment, representation or warranty which binds the other party or
otherwise act in the name of or on behalf of the other party.
ENZO and BAXTER agree that the distribution relationship between them does
not constitute, nor does it imply, a license of any of ENZO's technology or
patents, nor does it abrogate any of ENZO's rights under its patents. ENZO
maintains full rights under its PATENTS. The foregoing statements are
paramount to this AGREEMENT.
2. PRODUCTS, Price and Payment
A list of Enzo's current domestic retail price index is included in EXHIBIT
B hereto and incorporated by reference herein. The price to BAXTER for each
product shall be * the current domestic retail price as reflected by the
price index.
Prices to BAXTER may be adjusted no more than once during each calendar
year. ENZO has the right to adjust prices to BAXTER after providing BAXTER
with forty-five (45) days written notice. Any such price adjustment will
affect future purchases only and ENZO agrees to ▇▇▇▇▇ ▇▇▇▇▇▇'▇
----------
* The information omitted is confidential and has been filed separately with
the Commission pursuant to Rule 406.
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existing purchase orders on the effective date of such price adjustment at
the prices in effect prior to such effective date.
ENZO or BAXTER may propose in writing to delete PRODUCT in EXHIBIT B. ENZO
or BAXTER may propose to add PRODUCT or products to EXHIBIT B. Both
partners must agree in writing to such additions before such changes are
incorporated therein.
3. Distributor Duties
BAXTER shall:
a. submit its orders for the PRODUCTS on its standard purchase
order form. To the extent that the terms and conditions of
▇▇▇▇▇▇'▇ standard purchase order form are inconsistent with
the terms and conditions of this Agreement, the terms and
conditions of this Agreement shall govern;
b. pay for all such orders within thirty (30) days of the
invoice date for such order;
c. advertise and promote the PRODUCTS by methods which in
▇▇▇▇▇▇'▇ judgment are best suited for the sale of such
PRODUCTS;
4. Supplier's Duties
ENZO shall:
a. promptly ship to all BAXTER distribution centers in
accordance with the shipping instructions (compatible with
ENZO's shipping policy and PRODUCT stability) specified in
▇▇▇▇▇▇'▇ purchase orders, collect, F.O.B. origin, with
carrier to ▇▇▇▇ third party freight charges to ▇▇▇▇▇▇
Healthcare Corporation, Scientific Products freight payment,
▇.▇.▇▇▇ ▇▇▇, ▇▇▇▇▇▇▇▇▇, ▇▇▇▇▇▇▇▇ ▇▇▇▇▇. All direct (drop)
shipments to ▇▇▇▇▇▇'▇ customers by ENZO shall be F.O.B.
destination, Prepaid and Add. Baxter reserves the right to
determine the carriers to be selected for shipment to its
customers (compatible with ENZO's shipping policy and
PRODUCT stability);
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b. adequately package and deliver the PRODUCTS, using those
references to and trademarks of BAXTER as BAXTER shall
specify in writing;
c. execute and comply with the provisions of ▇▇▇▇▇▇'▇
Continuing Guaranty, a copy of which is attached hereto as
EXHIBIT C.
5. Forecasts and Purchase Orders for BAXTER Inventory
BAXTER shall issue a forecast schedule by the end of the mid-month of each
calendar quarter covering its estimated requirements for PRODUCTS for the
succeeding two (2) calendar quarters. Such forecast shall be considered for
planning purposes only and not in any way be considered a purchase
commitment.
A purchase order will be issued by BAXTER at least sixty (60) days in
advance of the requested delivery of PRODUCT. This purchase order will
indicate specific delivery and/or shipping requirements. Purchase orders
will be delivered to ENZO by Federal Express or similar carrier so that the
receipt can be confirmed. Orders placed with ENZO may not be canceled by
BAXTER more than * after issuance of order. ENZO shall meet such
requirements unless it advises BAXTER within * of the date of such purchase
order that it is unable to supply PRODUCT as ordered by BAXTER whereupon
the parties agree to discuss a revised schedule for delivery of PRODUCT to
BAXTER. After ENZO and BAXTER agree to the provisions of a revised
schedule, ENZO will make its best efforts to fulfill the provisions of the
revised schedule.
6. PRODUCT Deliveries and Specifications for BAXTER Inventory
Within thirty (30) days after the effective date of this Agreement, ENZO
shall provide BAXTER with PRODUCT specifications and package inserts for
those PRODUCTS in EXHIBIT B that BAXTER intends to distribute.
When an order is placed by BAXTER for its inventory ENZO shall ship the
PRODUCT in accordance with Section 4 above. ENZO shall supply, at the time
of shipment of the PRODUCT to BAXTER a statement that the PRODUCT conforms
to the PRODUCT specifications. If after receipt of the PRODUCT BAXTER
determines that it does not conform to the PRODUCT
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* The information omitted is confidential and has been filed separately with
the Commission pursuant to Rule 406.
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specification provided by ENZO, and that the failure to conform to the
PRODUCT specifications was not the direct result of shipping and handling,
BAXTER will provide ENZO with documentation of this failure to conform to
the PRODUCT specifications. If ENZO accepts the documentation provided by
▇▇▇▇▇▇ ▇▇▇▇ will ship a replacement order. If ENZO does not accept the
documentation provided by BAXTER then the differences in the determination
of the manufacturing specifications for the allegedly nonconforming PRODUCT
will be settled by representatives of the technical staffs of ENZO and
BAXTER.
7. Patents and Trademarks
a. Patents
ENZO shall defend, indemnify and hold harmless BAXTER from and against
any liability arising out of a claim of patent infringement with
respect to any of the PRODUCTS.
If BAXTER receives a notice from a third party asserting that any of
the PRODUCTS of this AGREEMENT infringe on an issued patent in the
country of sale, then BAXTER shall immediately give written notice to
ENZO. Upon notice to ENZO or BAXTER from a third party asserting that
any of the PRODUCTS of this AGREEMENT infringe on an issued patent in
the country in which such PRODUCTS are sold, ENZO has the right to
exclude such PRODUCTS from this AGREEMENT for that country and can
further by written notice instruct BAXTER to cease all such
distribution of such PRODUCT in that country. Further distribution of
PRODUCTS after such instruction from ENZO to BAXTER will be at the
sole risk of ▇▇▇▇▇▇ and ▇▇▇▇▇▇ shall indemnify and hold harmless ENZO
from all infringement liability and damages with respect to further
distribution of such PRODUCTS, including legal costs and attorneys
fees.
Notwithstanding any third party infringement claims, all provisions of
this AGREEMENT, including Section 6, shall not be affected but shall
remain in full force and effect to the fullest extent possible.
ENZO agrees to repurchase from BAXTER, at a price equivalent to the
full purchase price paid by BAXTER any quantity of PRODUCT in ▇▇▇▇▇▇'▇
inventory which BAXTER (i) has been instructed by ENZO to discontinue
the sale of such PRODUCT, or (ii) reasonably believes it should or
cannot sell, based upon an opinion of ▇▇▇▇▇▇'▇ counsel that future
sales by BAXTER may result in patent infringement, or
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because of a decision, whether interlocutory or final, rendered in any
patent infringement action.
b. Trademarks
ENZO recognizes that BAXTER is the owner of the trademarks and trade names
connoting BAXTER which it may elect to use in the promotion and sale of the
PRODUCTS and that ENZO has no ownership or other rights or interests in
such trademarks and trade names.
BAXTER recognizes that ENZO is the owner of the trademarks and trade names
connoting ENZO and ENZO's PRODUCTS which it may elect to use in the
promotion and sale of the PRODUCTS and that BAXTER has no ownership or
other rights or interests in such trademarks and trade names.
8. Sales Promotions
BAXTER shall use its best efforts in sales promotions and advertisement of
the PRODUCTS such as individual client contact, direct mailings, catalog
listings and trade meeting promotions. ENZO will provide BAXTER with one
(1) copy of the literature, technical data, specifications and the like
describing the PRODUCTS that BAXTER is distributing as they are currently
produced for the assistance of BAXTER in the preparation of advertising,
catalog and other sales and promotional material. BAXTER shall use its best
efforts to list PRODUCTS in its future published product catalog(s) in
which the PRODUCTS can be listed after the effective date of this
AGREEMENT.
9. PRODUCT Warranty
In addition to all other warranties given by ENZO in this AGREEMENT and the
exhibits hereto or otherwise, ENZO warrants that the PRODUCTS will conform
to the specifications and samples provided by ENZO for such PRODUCTS; will
be free from defects in design, materials and workmanship and are
merchantable and fit for their intended purposes. ENZO's sole obligation is
to replace the PRODUCTS with similar PRODUCTS to the extent of the purchase
price. THIS WARRANTY IS EXPRESSLY IN LIEU OF ANY OTHER WARRANTIES OR
LIABILITIES, EXPRESS OR IMPLIED, INCLUDING THE WARRANTIES OF
MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE.
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10. Storage and Stock Rotation
ENZO agrees to share with BAXTER all necessary storage and stock rotation
practices which apply to the PRODUCTS.
BAXTER further agrees to take diligent care not to ship PRODUCTS to its
customers which have expired, been damaged in storage or handling, or
improperly stored. BAXTER will be responsible for damages arising from its
shipment of expired, damaged, or improperly stored PRODUCTS.
11. Confidentiality of Information
BAXTER and ENZO agree that they will not disclose any proprietary and
confidential information made available to them by the other party. Both
parties further agree that all confidential material will be in writing and
marked confidential and that they will not make more copies that necessary
of documents or materials which are provided under this AGREEMENT, nor will
they distribute such documents or materials, or copies thereof, to any
third party. Furthermore, both parties agree to return any such documents
or materials, or copies thereof, which are provided under this AGREEMENT if
directed or requested to do so.
The above obligations shall not apply to those portions of ENZO's and
▇▇▇▇▇▇'▇ proprietary and confidential information which (1) are or become
generally publicly available through no act or failure to act by the
recipient party, (2) were demonstrably known to the other party prior to
disclosure under this AGREEMENTS, or (3) are subsequently disclosed by a
third party having a legal right to do so and not having a confidential
relationship with respect thereto.
12. Force Majeure
No liability shall result to either party from delay in performance or from
nonperformance under this Agreement caused by circumstances beyond the
reasonable control of the party who has delayed performance or not
performed. The nonperforming party shall be diligent in attempting to
remove any such cause and shall promptly notify the other party of its
extent and probable duration.
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13. Duration and Termination
This AGREEMENT shall become effective as of the date hereinabove written
and shall continue for a period of * . Unless terminated, it will continue
thereafter for successive renewal terms of * . Either party may terminate
this AGREEMENT without cause at any time by giving the other party notice
in writing at least * in advance of the effective termination date stated
in such notice.
Each party may also terminate this AGREEMENT * prior written notice to the
other party for a material breach by the other party of any of the
provisions of this AGREEMENT where such breach is not cured within said
notice period.
Upon termination of this AGREEMENT all distribution rights to BAXTER will
be deemed immediately canceled and returned in toto to ENZO.
15. Indemnification
Except to the extent the other is negligent or commits an act of wilful
misconduct or in default of the terms hereof, each of the parties agrees to
indemnify, defend and hold harmless the other party hereto, its successors
and assigns, employees and agents, from and against, any and all claims,
losses, liabilities, demands, damages, actions, suits, judgments, costs and
expenses (including reasonable attorneys' fees), incurred, relating to,
caused by or arising out of the breach of any covenant or agreement of such
party under this AGREEMENT.
16. Notices
All notices, requests, demands and other communications required or
permitted to be given hereunder shall be sent by personal delivery;
certified mail, return receipt requested; telecopier; or overnight courier
to the parties at the addresses set forth below or to such other address as
a party shall have previously designated by written notice to the other
party hereto in accordance with this section. Such notices shall be deemed
given at the time delivered, if delivered personally; five (5) days after
the day sent, if sent by certified mail; and one (1) business day after the
day sent, if telecopied or sent by overnight courier.
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* The information omitted is confidential and has been filed separately with
the Commission pursuant to Rule 406.
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ENZO: Enzo Biochem, Inc.
▇▇▇ ▇▇▇▇▇ ▇▇▇▇▇▇, ▇▇▇▇ ▇▇▇▇▇
▇▇▇ ▇▇▇▇, ▇▇▇ ▇▇▇▇ ▇▇▇▇▇
Attn: ▇▇. ▇▇▇▇▇▇▇ ▇. ▇▇▇▇▇▇▇▇▇▇
Vice President, Corporate Development
Fax No.: (▇▇▇) ▇▇▇-▇▇▇▇
BAXTER: ▇▇▇▇▇▇ Healthcare Corporation
▇▇▇▇ ▇▇▇▇▇▇▇▇ ▇▇▇▇
▇▇▇▇▇ ▇▇▇▇, ▇▇ ▇▇▇▇▇
Attn: ▇▇. ▇▇▇▇▇ ▇▇▇▇▇▇
Fax No. (▇▇▇) ▇▇▇-▇▇▇▇
17. Governing Law
This Agreement shall be governed, construed and enforced in accordance with
the internal laws of the State of New York, including the Uniform
Commercial Code as enacted in that jurisdiction, without giving effect to
any choice of law rules which may direct the application of the laws of
another jurisdiction.
18. Waiver
Any terms and conditions of this AGREEMENT may be waived at any time by the
party or parties entitled to the benefit thereof but only by a written
notice signed by the party or parties waiving such term or condition.
Waiver by ENZO or BAXTER of any provision of this AGREEMENT shall not be
deemed a waiver of future compliance therewith and such provision as well
as all other provisions hereunder shall remain in full force and effect.
19. Compliance with Laws
Each party will comply with all United States laws, ordinances and
regulations properly applicable to the manufacture, sale and distribution
of the PRODUCTS described herein. Where applicable, the parties will comply
with the laws of the country in which the product is being sold.
20. Headings
All Headings of the clauses of this AGREEMENT are inserted for convenience
only and shall not affect any construction or interpretation of this
AGREEMENT.
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21. Severability
In the event that any clause of this Agreement shall be found to be void or
unenforceable, such finding shall not be construed to render any other
clause of this AGREEMENT either void or unenforceable, and all other
clauses shall remain in full force and effect unless the clause(s) which
is/are invalid or unenforceable shall substantially affect the rights or
obligations granted to or undertaken by either party.
22. Assignment
This AGREEMENT may not be assigned by either party without the prior
written consent of the other party hereto, provided that BAXTER may assign
this AGREEMENT to any purchaser of all or substantially all of the assets
of the Sellers' Scientific Products, Industrial and Lifesciences division.
Any assignment which does not comply with the foregoing shall be null and
void.
23. Counterparts
This AGREEMENT may be executed in two or more counterparts, each of which
shall be deemed an original, but all of which together shall constitute one
and the same instrument.
22. Entire Agreement
This AGREEMENT together with the EXHIBITS attached hereto embodies the
entire understanding between the parties hereto with respect to the subject
matter hereof, and there are no contracts or prior drafts of the AGREEMENT,
understandings, conditions, warranties or representations, oral or written,
express or implied, with reference to the subject matter hereof which are
not merged herein. Except as otherwise specifically stated, no amendment or
modification of this AGREEMENT shall be of any force or effect unless
reduced to writing and signed by both parties hereto.
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IN WITNESS, WHEREOF, the parties have caused this AGREEMENT to be executed
by their duly authorized representatives.
Enzo Diagnostics, Inc. ▇▇▇▇▇▇ Healthcare Corporation
Scientific Products, Industrial and
Lifesciences Division
By:___________________________ By:___________________________
Title: President Title: V.P. Marketing
------------------------ ------------------------
Date: 9/14/95 Date: 9/15/95
------------------------- -------------------------
* * * * * * *
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EXHIBIT A
Enzo Diagnostics, Inc. Issued Patents
U.S. Patents
======================================================================================================
Patent Number Title/Inventor Issue Date
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4,687,732 Visualization Polymers and Their Aug. 18, 1987
Application to Diagnostic Medicine
▇▇▇▇▇ ▇. ▇▇▇▇ et al.
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4,707,352 Method of Radioactively Labeling Nov. 17, 1987
Diagnostic and Therapeutic Agents
Containing a Chelating Group
▇▇▇▇▇▇ ▇. ▇▇▇▇▇▇▇▇▇▇▇▇▇▇▇
------------------------------------------------------------------------------------------------------
4,707,440 Nucleic Acid Hybridization Assay and Nov. 17, 1987
Detectable Molecules Useful in Such Assay
▇▇▇▇▇▇ ▇. ▇▇▇▇▇▇▇▇▇▇▇▇▇▇▇
------------------------------------------------------------------------------------------------------
4,711,955 Modified Nucleotides and Methods of Dec. 8, 1987
Preparing and Using Same
▇▇▇▇▇ ▇. ▇▇▇▇ et al.
------------------------------------------------------------------------------------------------------
4,746,604 Specific Binding Assays Utilizing A Viable May 24, 1988
Cell as a Label
▇▇▇▇▇▇▇ ▇▇▇▇▇▇▇▇▇▇
------------------------------------------------------------------------------------------------------
4,755,458 Composition and Method for the Detection Jul. 5, 1988
of the Presence of a Polynucleotide
Sequence of Interest
▇▇▇▇▇▇ ▇▇▇▇▇▇▇ et al.
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4,767,609 Therapeutic and Diagnostic Processes Aug. 30, 1988
Using Isotope Transfer to Chelator-Target
Recognition Molecule Conjugate
▇▇▇▇▇▇ ▇. ▇▇▇▇▇▇▇▇▇▇▇▇▇▇▇
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4,772,548 Radioisotopicassay Using Isotope Transfer Sep. 20, 1988
to Chelator-Target Recognition Molecule
Conjugate
▇▇▇▇▇▇ ▇. ▇▇▇▇▇▇▇▇▇▇▇▇▇▇▇
------------------------------------------------------------------------------------------------------
4,843,122 Detectable Molecules, Method of June 27, 1989
Preparation and Use
▇▇▇▇▇▇ ▇. ▇▇▇▇▇▇▇▇▇▇▇▇▇▇▇
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4,849,208 Detectable Molecules, Method of Jul. 18, 1989
Preparation and Use
▇▇▇▇▇▇ ▇. ▇▇▇▇▇▇▇▇▇▇▇▇▇▇▇
======================================================================================================
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======================================================================================================
Patent Number Title/Inventor Issue Date
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4,849,505 Detectable Molecules, Method of Jul. 18, 1989
Preparation and Use
▇▇▇▇▇▇ ▇. ▇▇▇▇▇▇▇▇▇▇▇▇▇▇▇
------------------------------------------------------------------------------------------------------
4,868,103 Analyte Detection by Means of Energy Sep. 19, 1989
Transfer
▇▇▇▇▇▇ ▇. ▇▇▇▇▇▇▇▇▇▇▇▇▇▇▇
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4,889,798 Heterologous System for the Detection of Dec. 26, 1989
Chemically Labeled DNA and other
Biological Materials Providing a Receptor or
Target Moiety Thereon
▇▇▇▇▇▇ ▇▇▇▇▇▇▇
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4,894,325 Hybridization Method for the Detection of Jan. 16, 1990
Genetic Material
▇▇▇▇ ▇▇▇▇▇▇▇▇▇▇ et al.
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4,900,659 Nucleotide Sequence Composition and Feb. 13, 1990
Method for Detection for Neissera
Gonorrhoeae and Method for Screening for
a Nucleotide Sequence that is Specific for
a Genetically Distinct Group
▇▇▇▇▇▇ ▇▇ et al.
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4,943,523 Detectable Molecules, Method of Jul. 24, 1990
Preparation and Use
▇▇▇▇▇▇ ▇. ▇▇▇▇▇▇▇▇▇▇▇▇▇▇▇
------------------------------------------------------------------------------------------------------
4,952,685 Detectable Molecules, Method of Aug. 28, 1990
Preparation and Use
▇▇▇▇▇▇ ▇. ▇▇▇▇▇▇▇▇▇▇▇▇▇▇▇
------------------------------------------------------------------------------------------------------
4,987,065 In Vivo Labelling of Polynucleotide Jan. 22, 1991
Sequences
▇▇▇▇▇▇ ▇. ▇▇▇▇▇▇▇▇▇▇▇▇▇▇▇ et al.
------------------------------------------------------------------------------------------------------
4,994,373 Method and Structures Employing Feb. 19, 1991
Chemically-Labelled Polynucleotide Probes
▇▇▇▇▇▇ ▇. ▇▇▇▇▇▇▇▇▇▇▇▇▇▇▇ et al.
------------------------------------------------------------------------------------------------------
5,002,885 Detectable Molecules, Method of Mar. 26, 1991
Preparation and Use
▇▇▇▇▇▇ ▇. ▇▇▇▇▇▇▇▇▇▇▇▇▇▇▇
------------------------------------------------------------------------------------------------------
5,013,831 Detectable Molecules, Method of May 7, 1991
Preparation and Use
▇▇▇▇▇▇ ▇. ▇▇▇▇▇▇▇▇▇▇▇▇▇▇▇
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5,024,933 Method and Kit for Sample Adherence to June 18, 1991
Test Substrate
▇▇▇▇-▇▇▇▇ Yang et al.
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5,061,076 Time-Resolved Fluorometer Oct. 29, 1991
▇▇▇ ▇▇▇▇▇▇
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5,082,830 End Labeled Nucleotide Probe Jan. 21, 1992
▇▇▇▇▇▇▇▇▇ ▇. ▇▇▇▇▇▇ et al.
======================================================================================================
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======================================================================================================
Patent Number Title/Inventor Issue Date
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5,175,269 Compound and Detectable Molecules Dec. 29, 1992
Having An Oligo- or Polynucleotide with
Modifiable Reactive Group
▇▇▇▇▇▇ ▇. ▇▇▇▇▇▇▇▇▇▇▇▇▇▇▇
------------------------------------------------------------------------------------------------------
5,241,060 Base Moiety-Labeled Detectable Nucleotide Aug. 31, 1993
▇▇▇▇ ▇▇▇▇▇▇▇▇▇▇ et al.
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5,260,433 Saccharide Specific Binding System Nov. 9, 1993
Labeled Nucleotides
▇▇▇▇ ▇▇▇▇▇▇▇▇▇▇ et al.
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5,288,609 Capture Sandwich Hybridization Method Feb. 22, 1994
and Composition
▇▇▇▇ ▇▇▇▇▇▇▇▇▇▇ et al.
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5,328,824 Methods of Using Labeled Nucleotides Jul. 12, 1994
7 ▇▇▇▇▇ ▇. ▇▇▇▇
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5,449,767 Modified Polynucleotides and Methods of Sep. 12, 1995
Preparing Same
▇▇▇▇▇ ▇. ▇▇▇▇ et al.
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Foreign Patents Granted
======================================================================================================
Patent Number Publication
(Country) Title/Inventor Date
of Patent Grant
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560 651 Modified Nucleotides and Methods Oct. 16, 1987
(Australia) of Preparing and Using Same (16 yr. term
▇▇▇▇▇ ▇. ▇▇▇▇ et al. began Apr. 13,
1982)
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1 219 824 Modified Nucleotides and Methods Mar. 31, 1987
(Canada) of Preparing and Using Same
▇▇▇▇▇ ▇. ▇▇▇▇ et al.
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1 223 831 Modified Nucleotides, Methods of Jul. 7, 1987
(Canada) Preparing and Utilizing and
Compositions Containing the Same
▇▇▇▇ ▇. ▇▇▇▇▇▇▇▇▇▇ et al.
------------------------------------------------------------------------------------------------------
EP 0 285 057 B1 Modified Nucleotides, Methods of May 10, 1988
Preparing and Utilizing and
Compositions Containing the Same
▇▇▇▇ ▇. ▇▇▇▇▇▇▇▇▇▇ et al.
------------------------------------------------------------------------------------------------------
EP 0 063 879 B1 Modified Nucleotides and Methods Nov. 23, 1989
of Preparing and Using Same
▇▇▇▇▇ ▇. ▇▇▇▇ et al.
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1,237,369 Visualization Polymers and Their May 31, 1988
Application to Diagnostic Medicine
▇▇▇▇▇ ▇. ▇▇▇▇ et al.
------------------------------------------------------------------------------------------------------
1,254,525 Kit for Terminally Chemically May 23, 1989
Labeling DNA
▇▇▇▇▇▇▇▇▇ ▇. ▇▇▇▇▇▇ et al.
------------------------------------------------------------------------------------------------------
1,256,023 Method of Radioactively Labeling June 20, 1989
Diagnostic and Therapeutic Agents
Containing a Chelating Group
▇▇▇▇▇▇ ▇▇▇▇▇▇▇▇▇▇▇▇▇▇▇
------------------------------------------------------------------------------------------------------
1,260,368 Composition and Method for the Sept. 26, 1989
Detection of the Presence of a Polynucleotide
Sequence of Interest ▇▇▇▇▇▇ ▇▇▇▇▇▇▇ et al.
------------------------------------------------------------------------------------------------------
-17-
------------------------------------------------------------------------------------------------------
1,260,372 Hybridization Method for the Sept. 26, 1989
Detection of Genetic Materials
▇▇▇▇▇▇ ▇▇▇▇▇▇▇ et al.
======================================================================================================
-18-
=====================================================================================================
Patent Number Publication
(Country) Title/Inventor Date
of Patent Grant
-----------------------------------------------------------------------------------------------------
1,268,115 Method and Composition for April 24, 1990
Detecting Analyte Moieties
▇▇▇▇▇▇▇ ▇▇▇▇▇▇▇▇▇▇
-----------------------------------------------------------------------------------------------------
1,281,283 Method for Detecting an Analyte Mar. 12, 1991
(Canada) Moiety by Means of Signal
Localization
▇▇▇▇▇▇ ▇▇▇▇▇▇▇
-----------------------------------------------------------------------------------------------------
1,285,330 Analyte Detection by Means of June 25, 1991
Energy Transfer
▇▇▇▇▇▇ ▇▇▇▇▇▇▇▇▇▇▇▇▇▇▇ et al.
-----------------------------------------------------------------------------------------------------
1,288,811 Assay Method Utilizing Nov. 3, 1987
Polynucleotide Sequences
▇▇▇▇▇▇ ▇▇▇▇▇▇▇▇▇▇ et al.
-----------------------------------------------------------------------------------------------------
EP 0 133 473 B1 In Vivo Labelling of Polynucleotide March 23,
Sequences 1994
▇▇▇▇▇▇ ▇▇▇▇▇▇▇▇▇▇▇▇▇▇▇ et al.
-----------------------------------------------------------------------------------------------------
EP 0 173 339 B1 Composition and Method for the Jan. 22, 1992
Detection of the Presence of a
Polynucleotide Sequence of Interest
▇▇▇▇▇▇ ▇▇▇▇▇▇▇ et al.
-----------------------------------------------------------------------------------------------------
EP 0 212 546 B1 Method for Labeling Polynucleotide Apr. 1, 1992
Sequences
▇▇▇▇▇▇ ▇▇▇▇▇▇▇▇▇▇▇▇▇▇▇ et al.
-----------------------------------------------------------------------------------------------------
1,295,559 Method for Labeling Polynucleotide Feb. 11, 1992
Sequences
▇▇▇▇▇▇ ▇▇▇▇▇▇▇▇▇▇▇▇▇▇▇ et al.
-----------------------------------------------------------------------------------------------------
-19-
-----------------------------------------------------------------------------------------------------
1,299,073 Nucleotide Sequence Composition Apr. 21, 1992
Method for Detection of Neisseria
(Canada) gonorrhoeae and Method for
Screening for a Nucleotide
Sequence that is Specific for a
Genetically Distinct Group
▇▇▇▇▇▇ ▇▇ & ▇▇▇▇-▇▇▇▇ ▇▇▇▇
-----------------------------------------------------------------------------------------------------
1,309,672 Methods and Structures Employing Nov. 3, 1992
Non-Radioactive Chemically-Labeled
Polynucleotide Probes
▇▇▇▇▇▇ ▇▇▇▇▇▇▇▇▇▇▇▇▇▇▇
=====================================================================================================
-20-
=====================================================================================================
Patent Number Publication
(Country) Title/Inventor Date
of Patent Grant
-----------------------------------------------------------------------------------------------------
1,314,503 Detectable Moelcules, Method of March 16,
Preparation And Use 1993
▇▇▇▇▇▇ ▇▇▇▇▇▇▇▇▇▇▇▇▇▇▇
-----------------------------------------------------------------------------------------------------
1,314,810 Heterologous System for the March 23,
Detection of Chemically-Labeled 1993
DNA and Other Biological Materials
Providing a Receptor or Target
Moiety Thereon
▇▇▇▇▇▇ ▇▇▇▇▇▇▇
-----------------------------------------------------------------------------------------------------
EP 0 242 527 B1 Analyte Detection by Means of May 13, 1992
Energy Transfer
▇▇▇▇▇▇ ▇▇▇▇▇▇▇▇▇▇▇▇▇▇▇ et al.
-----------------------------------------------------------------------------------------------------
1,315,222 Polynucleotide Probes and a March 30,
Method for Their Preparation 1993
▇▇▇▇▇ ▇▇▇ et al.
-----------------------------------------------------------------------------------------------------
0 149 654 B1 Detecting Agent Carrying Polymer Sep. 9, 1992
Having Multiple Units of
Visualization Monomer
▇▇▇▇▇ ▇. ▇▇▇▇ et al.
-----------------------------------------------------------------------------------------------------
EP 0 097 373 B1 Modified Nucleotides, Methods of Oct. 7, 1992
Preparing and Utilizing and
Compositions Containing the Same
▇▇▇▇ ▇. ▇▇▇▇▇▇▇▇▇▇ et al.
-----------------------------------------------------------------------------------------------------
EP 0 212 670 B1 Method for Detecting an Analyte Nov. 4, 1992
Moiety by Means of Signal
Localization
▇▇▇▇▇▇ ▇▇▇▇▇▇▇
-----------------------------------------------------------------------------------------------------
EP 0 117 440 B1 Method and Structures Employing Apr. 7, 1993
Chemically-Labelled Polynucleotide
Probes
▇▇▇▇▇▇ ▇. ▇▇▇▇▇▇▇▇▇▇▇▇▇▇▇ et al.
-----------------------------------------------------------------------------------------------------
EP 0 244 860 B1 Polynucleotide Probes and a ▇▇▇. ▇, ▇▇▇▇
▇▇▇▇▇▇ for their Preparation
▇▇▇▇▇ ▇. ▇▇▇ et al.
=====================================================================================================
-21-
=====================================================================================================
Patent Number Publication
(Country) Title/Inventor Date
of Patent Grant
-----------------------------------------------------------------------------------------------------
EP 0 343 424 B1 Method and Kit for Sample Apr. 21, 1993
Adherence to Test Substrate
▇▇▇▇-▇▇▇▇ ▇▇▇▇ et al.
-----------------------------------------------------------------------------------------------------
EP 0 159 719 B1 Hybridization Method for the Jun. 30, 1993
Detection of Genetic Material
▇▇▇▇ ▇▇▇▇▇▇▇▇▇▇ et al.
-----------------------------------------------------------------------------------------------------
EP 0 122 614 B1 Kit for Terminally Chemically Jul. 14, 1993
Labelling DNA
▇▇▇▇▇▇▇▇▇ ▇▇▇▇▇▇
-----------------------------------------------------------------------------------------------------
EP 0 150 844 B1 Method of Radioactively Labeling Jul. 28, 1993
Diagnostic and Therapeutic Agents
Containing a Chelating Group
Jannis Stavrianpoulos
-----------------------------------------------------------------------------------------------------
EP 0 237 737 B1 A Composition Specific for Sep. 8, 1993
Neisseria Gonorrhoea
▇▇▇▇▇▇ ▇▇ et al.
=====================================================================================================
The PRODUCTS listed in Exhibit B are covered by one or more patents of Enzo,
including the patents listed above.
This list may be updated quarterly at Enzo's discretion.
-22-
EXHIBIT B
ENZO PRICE INDEX 1996
-------------------------------------------------------------------------------------------------------------------
NONRADIOACTIVE LABELING OF NUCLEIC ACIDS
-------------------------------------------------------------------------------------------------------------------
Cat. No. Product Quantity Price
BIOPROBE(R) NICK TRANSLATION DNA LABELING SYSTEM
Nick Translation Labeling Kits
42710-11 Nick Translation Kit with Bio-11-dUTP.....................................25 reactions $230.00
42710-12 Nick Translation Kit with Bio-16-dUTP.....................................25 reactions 230.00
42710-13 Nick Translation Kit with Bio-11-dCTP.....................................25 reactions 230.00
42710-14 Nick Translation Kit with Bio-7-dATP......................................25 reactions 230.00
42710-16 Nick Translation Kit with Fluorescein-12-dUTP.............................25 reactions 230.00
Nick Translation Deoxynucleotide Packs
42711 Bio-11-dUTP for Nick Translation..........................................25 reactions 140.00
42712 Bio-16-dUTP for Nick Translation..........................................25 reactions 140.00
42713 Bio-11-dCTP for Nick Translation..........................................25 reactions 140.00
42714 Bio-7-dATP for Nick Translation...........................................25 reactions 140.00
42716 Fluorescein-12-dUTP for Nick Translation..................................25 reactions 140.00
Nick Translation Reagent Pack
42710 Reagent Pack for Nick Translation.........................................25 reactions 105.00
BIOPROBE(R) RANDOM PRIMED DNA LABELING SYSTEM
Random Primed Labeling Kits
42720-21 Random Primed Labeling Kit with Bio-11-dUTP...............................25 reactions 230.00
42720-22 Random Primed Labeling Kit with Bio-16-dUTP...............................25 reactions 230.00
42720-23 Random Primed Labeling Kit with Bio-11-dCTP...............................25 reactions 230.00
42720-24 Random Primed Labeling Kit with Bio-7-dATP................................25 reactions 230.00
42720-26 Random Primed Labeling Kit with Fluorescein-12-dUTP.......................25 reactions 230.00
Random Primed Deoxynucleotide Packs
42721 Bio-11-dUTP for Random Primed Labeling....................................25 reactions 140.00
42722 Bio-16-dUTP for Random Primed Labeling....................................25 reactions 140.00
42723 Bio-11-dCTP for Random Primed Labeling....................................25 reactions 140.00
42724 Bio-7-dATP for Random Primed Labeling.....................................25 reactions 140.00
42726 Fluorescein-12-dUTP for Random Primed Labeling............................25 reactions 140.00
Random Primed Labeling Reagent Pack
42720 Reagent Pack for Random Primed Labeling...................................25 reactions 105.00
--------------------------------------------------------------------------------
NONRADIOACTIVE LABAELING OF NUCLEIC ACIDS
-------------------------------------------------------------------------------------------------------------------
Cat. No. Product Quantity Price
BIOPROBE(R) 3' OLIGONUCLEOTIDE LABELING SYSTEM
3' Oligo Labeling Kits
42730-31 3' Oligo Labeling Kit with Bio-16-ddUTP...................................25 reactions $315.00
42730-33 3' Oligo Labeling Kit with Fluorescein-12-ddUTP...........................25 reactions 315.00
3'Oligo Dideoxynucleotide Packs
42731 Bio-16-ddUTP for 3' Oligo Labeling........................................25 reactions 140.00
42733 Fluorescein-12-ddUTP for 3' Oligo Labeling................................25 reactions 140.00
3' OligoTailing Kits
42730-41 3' Oligo Tailing Kit with Bio-11-dUTP.....................................25 reactions 315.00
42730-42 3' Oligo Tailing Kit with Bio-16-dUTP.....................................25 reactions 315.00
42730-43 3' Oligo Tailing Kit with Bio-11-dCTP.....................................25 reactions 315.00
42730-44 3' Oligo Tailing Kit with Bio-7-dATP......................................25 reactions 315.00
42730-46 3' Oligo Tailing Kit with Fluorescein-12-dUTP.............................25 reactions 315.00
3'Oligo Deoxynucleotide Packs
42741 Bio-11-dUTP for 3' Oligo Tailing..........................................25 reactions 140.00
42742 Bio-16-dUTP for 3' Oligo Tailing..........................................25 reactions 140.00
42743 Bio-11-dCTP for 3' Oligo Tailing..........................................25 reactions 140.00
42744 Bio-7-dATP for 3' Oligo Tailing...........................................25 reactions 140.00
42746 Fluorescein-12-dUTP for 3' Oligo Tailing..................................25 reactions 140.00
OligoBridge(TM) Labeling Kits
42730-36 OligoBridge(TM)Labeling Kit.................................................25 reactions 315.00
OligoBridge(TM) Nucleotide Pack
42736 Nucleotide Pack for OligoBridge(TM)Labeling.................................25 reactions 140.00
Oligo Labeling Reagent Pack
42730 Reagent Pack for Oligonucleotide Labeling.................................25 reactions 190.00
BIOPROBE(R) RNA TRANSCRIPT LABELING SYSTEM
RNA Labeling Kits
42750-51 RNA Labeling Kit with Bio-11-UTP..........................................20 reactions 330.00
42750-52 RNA Labeling Kit with Bio-16-UTP..........................................20 reactions 330.00
42750-53 RNA Labeling Kit with Bio-11-CTP..........................................20 reactions 330.00
42750-54 RNA Labeling Kit with Bio-17-ATP..........................................20 reactions 330.00
42750-56 RNA Labeling Kit with Fluorescein-12-UTP..................................20 reactions 330.00
- 2 -
-------------------------------------------------------------------------------------------------------------------
NONRADIOACTIVE LABAELING OF NUCLEIC ACIDS (continued)
-------------------------------------------------------------------------------------------------------------------
Cat. No. Product Quantity Price
Ribonucleotide Packs
42751 Bio-11-UTP for RNA Labeling...............................................25 reactions $225.00
42752 Bio-16-UTP for RNA Labeling...............................................25 reactions 225.00
42733 Bio-11-CTP for RNA Labeling...............................................25 reactions 225.00
42754 Bio-17-ATP for RNA Labeling...............................................25 reactions 225.00
42756 Fluorescein-12-UTP for RNA Labeling.......................................25 reactions 225.00
RNA Labeling Reagent Pack
42720 Reagent Pack for RNA Labeling.............................................25 reactions 225.00
-------------------------------------------------------------------------------------------------------------------
NUCLEOTIDES
-------------------------------------------------------------------------------------------------------------------
Cat. No. Product Quantity Price
DEOXYNUCLEOTIDES
42806 Bio-11-dUTP....................................................................50 nmol $285.00
42811 Bio-16-dUTP....................................................................50 nmol 285.00
42816 Bio-11-dCTP....................................................................50 nmol 285.00
42812 Bio-AP3-dCTP.................................................................22.5 nmol 230.00
42819 Bio-7-dATP.....................................................................50 nmol 285.00
42831 Fluorescein-12-dUTP............................................................25 nmol 140.00
42841 Rhodamine-dUTP.................................................................25 nmol 140.00
42851 Coumarin-dUTP..................................................................25 nmol 140.00
DIDEOXYNUCLEOTIDES
42813 Bio-16-ddUTP...................................................................25 nmol 140.00
42833 Fluorescein-12-ddUTP...........................................................25 nmol 140.00
RIBONUCLEOTIDES
42815 Bio-11-UTP....................................................................250 nmol 140.00
42814 Bio-16-UTP....................................................................250 nmol 140.00
42818 Bio-11-CTP....................................................................250 nmol 140.00
42817 Bio-17-ATP....................................................................250 nmol 140.00
42834 Fluorescein-12-UTP............................................................250 nmol 140.00
-------------------------------------------------------------------------------------------------------------------
LABELING ACCESSORIES - GLASS FIBER FILTERS
-------------------------------------------------------------------------------------------------------------------
Cat. No. Product Quantity Price
44524 Disc (24 mm diameter)..........................................................400/box $ 60.00
44525 Disc (25 mm diameter)..........................................................400/box 60.00
44101 Rectangle (10.25 cm x 25.4 cm).................................................100/box 120.00
- 3 -
-------------------------------------------------------------------------------------------------------------------
MEMBRANE HYBRIDIZATION AND DETECTION
-------------------------------------------------------------------------------------------------------------------
Cat. No. Product Quantity Price
MaxSense(TM) Membrane Hybridization Systems
45500 MaxSense(TM) BioProbe(R) Membrane Hybridization System
(for DNA & RNA Probes) .........10 blots 10 x 10 cm each $135.00
45600 MaxSense(TM) OligoProbe Membrane Hybridization System
(for Oligonucleotide Probes) ...10 blots 10 x 10 cm each 135.00
MaxSense(TM) Detection Systems
45401 BioDETEK(R)HP Hrp Membrane Detection System...................................1000 cm2 195.00
45402 BioDETEK(R)Alk Membrane Detection System......................................1000 cm2 195.00
45405 FluorDETEK(R)Hrp Membrane Detection System....................................1000 cm2 195.00
45406 FluorDETEK(R)AP Membrane Detection System.....................................1000 cm2 195.00
MaxSense(TM) BioProbe(R)Hybridization and Detection System Kits
for DNA and RNA Probes
Horseradish Peroxidase Detection System
45501 BioDETEK(R)HP Hrp Complete BioProbe(R)Membrane System..........10 blots 10 x 10 cm each 310.00
45505 FluorDETEK(R)Hrp Complete BioProbe(R)Membrane System...........10 blots 10 x 10 cm each 310.00
Alkaline Phosphatase Detection System
45502 BioDETEK(R)Alk Complete BioProbe(R)Membrane System.............10 blots 10 x 10 cm each 310.00
45506 FluorDETEK(R)AP Complete BioProbe(R)Membrane System............10 blots 10 x 10 cm each 310.00
MaxSense(TM) OligoProbe Hybridization and Detection System Kits
for Oligonucleotide Probes
Horseradish Peroxidase Detection System
45601 BioDETEK(R)HP Hrp Complete OligoProbe Membrane System..........10 blots 10 x 10 cm each 310.00
45605 FluorDETEK(R)Hrp Complete OligoProbe Membrane System...........10 blots 10 x 10 cm each 310.00
Alkaline Phosphatase Detection System
45602 BioDETEK(R)Alk Complete OligoProbe Membrane System.............10 blots 10 x 10 cm each 310.00
45606 FluorDETEK(R)AP Complete OligoProbe Membrane System............10 blots 10 x 10 cm each 310.00
MaxSense(TM) Hybridization and Detection System Accessories
45701 Hybridization Membrane..............................................roll, 30 cm x 3 m 225.00
45702 Hybridization Membrane........................................10 sheets, 15 cm x 10 cm 95.00
45703 Liquid Blocking Solution........................................................100 ml 50.00
45704 Liquid Blocking Reagent (concentrated)..........................................100 ml 80.00
45705 MaxSense(TM)BioProbe(R)Hybridization Buffer.....................................150 ml 50.00
45706 MaxSense(TM)OligoProbe Hybridization Buffer.....................................150 ml 50.00
- 4 -
-------------------------------------------------------------------------------------------------------------------
MEMBRANE HYBRIDIZATION AND DETECTION (continued)
-------------------------------------------------------------------------------------------------------------------
Cat. No. Product Quantity Price
Dot Blot System
46305 Dot Blot Hybridization and Detection Assay Kit............................100 test kit $750.00
46305/C Dot Blot Control DNA Pack.......................................................1 pack 170.00
46307 Dot Blot CMV Control DNA Pack...................................................1 pack 135.00
46308 Dot Blot HBV Control DNA Pack...................................................1 pack 135.00
-------------------------------------------------------------------------------------------------------------------
IN SITU HYBRIDIZATION ASSAY SYSTEMS
-------------------------------------------------------------------------------------------------------------------
Cat. No. Product Quantity Price
Simply Sensitive Detection Systems
32830 Hrp - AEC System for in situ Detection.......................................20 slides $95.00
32840 Hrp - DAB System for in situ Detection......................................20 slides 95.00
32850 Fl-SA System for in situ Detection...........................................20 slides 95.00
32860 Alk Phos - INT / BCIP System for in situ Detection...........................20 slides 95.00
32870 Alk Phos - NBT / BCIP System for in situ Detection...........................20 slides 95.00
Ultrasensitive Enhanced Detection Systems
32300 Enhanced Hrp - AEC System for in situ Detection..............................30 slides 140.00
32400 Enhanced Hrp - DAB System for in situ Detection.............................30 slides 140.00
32500 Enhanced Fl -SA System for in situ Detection.................................30 slides 140.00
32600 Enhanced Alk Phos - INT / BCIP System for in situ Detection..................30 slides 140.00
32700 Enhanced Alk Phos - NBT / BCIP System for in situ Detection..................30 slides 140.00
Simply Sensitive - Horseradish Peroxidase - AEC Detection
32801-30 PathoGene(R)Assay for Adenovirus / Hrp - AEC..................................20 slides 235.00
32802-30 PathoGene(R)Assay for Cytomegalovirus / Hrp - AEC.............................20 slides 235.00
32803-30 PathoGene(R)Assay for ▇▇▇▇▇▇▇-▇▇▇▇ Virus / Hrp - AEC..........................20 slides 235.00
32804-30 PathoGene(R)Assay for Hepatitis B Virus / Hrp - AEC...........................20 slides 235.00
32805-30 PathoGene(R)Assay for Herpes Simplex Virus / Hrp - AEC........................20 slides 235.00
32806-30 PathoGene(R)Assay for Chlamydia trachomatis / Hrp - AEC.......................20 slides 235.00
Simply Sensitive - Horseradish Peroxidase - DAB Detection
32801-40 PathoGene(R)Assay for Adenovirus / Hrp - DAB..................................20 slides 235.00
32802-40 PathoGene(R)Assay for Cytomegalovirus / Hrp - DAB.............................20 slides 235.00
32803-40 PathoGene(R)Assay for ▇▇▇▇▇▇▇-▇▇▇▇ Virus / Hrp - DAB..........................20 slides 235.00
32804-40 PathoGene(R)Assay for Hepatitis B Virus / Hrp - DAB...........................20 slides 235.00
32805-40 PathoGene(R)Assay for Herpes Simplex Virus / Hrp - DAB........................20 slides 235.00
32806-40 PathoGene(R)Assay for Chlamydia trachomatis / Hrp - DAB.......................20 slides 235.00
- 5 -
IN SITU HYBRIDIZATION ASSAY SYSTEMS (continued)
-------------------------------------------------------------------------------------------------------------------
Cat. No. Product Quantity Price
Simply Sensitive - Fluorescent Streptavidin Detection
32801-50 PathoGene(R)Assay for Adenovirus / Fl-SA......................................20 slides 235.00
32802-50 PathoGene(R)Assay for Cytomegalovirus / Fl-SA.................................20 slides 235.00
32803-50 PathoGene(R)Assay for ▇▇▇▇▇▇▇-▇▇▇▇ Virus / Fl-SA..............................20 slides 235.00
32804-50 PathoGene(R)Assay for Hepatitis B Virus / Fl-SA...............................20 slides 235.00
32805-50 PathoGene(R)Assay for Herpes Simplex Virus / Fl-SA............................20 slides 235.00
32806-50 PathoGene(R)Assay for Chlamydia trachomatis / Fl-SA...........................20 slides 235.00
Simply Sensitive - Alkaline Phosphatase - INT / BCIP Detection
32801-60 PathoGene(R)Assay for Adenovirus / Alk Phos - NBT / BCIP.....................20 slides $235.00
32802-60 PathoGene(R)Assay for Cytomegalovirus / Alk Phos - NBT / BCIP................20 slides 235.00
32803-60 PathoGene(R)Assay for ▇▇▇▇▇▇▇-▇▇▇▇ Virus / Alk Phos - NBT / BCIP.............20 slides 235.00
32804-60 PathoGene(R)Assay for Hepatitis B Virus / Alk Phos - NBT / BCIP..............20 slides 235.00
32805-60 PathoGene(R)Assay for Herpes Simplex Virus / Alk Phos - NBT / BCIP...........20 slides 235.00
32806-60 PathoGene(R)Assay for Chlamydia trachomatis / Alk Phos - NBT / BCIP..........20 slides 235.00
Simply Sensitive - Alkaline Phosphatase - NBT / BCIP Detection
32801-70 PathoGene(R)Assay for Adenovirus / Alk Phos - NBT / BCIP.....................20 slides 235.00
32802-70 PathoGene(R)Assay for Cytomegalovirus / Alk Phos - NBT / BCIP................20 slides 235.00
32803-70 PathoGene(R)Assay for ▇▇▇▇▇▇▇-▇▇▇▇ Virus / Alk Phos - NBT / BCIP.............20 slides 235.00
32804-70 PathoGene(R)Assay for Hepatitis B Virus / Alk Phos - NBT / BCIP..............20 slides 235.00
32805-70 PathoGene(R)Assay for Herpes Simplex Virus / Alk Phos - NBT / BCIP...........20 slides 235.00
32806-70 PathoGene(R)Assay for Chlamydia trachomatis / Alk Phos - NBT / BCIP..........20 slides 235.00
Ultrasensitive Enhanced - Horseradish Peroxidase - AEC Detection
32801-33 PathoGene(R)Assay for Adenovirus / Enhanced Hrp - AEC .......................20 slides 290.00
32802-33 PathoGene(R)Assay for Cytomegalovirus / Enhanced Hrp - AEC...................20 slides 290.00
32803-33 PathoGene(R)Assay for ▇▇▇▇▇▇▇-▇▇▇▇ Virus / Enhanced Hrp - AEC................20 slides 290.00
32804-33 PathoGene(R)Assay for Hepatitis B Virus / Enhanced Hrp - AEC.................20 slides 290.00
32805-33 PathoGene(R)Assay for Herpes Simplex Virus / Enhanced Hrp - AEC..............20 slides 290.00
32806-33 PathoGene(R)Assay for Chlamydia trachomatis / Enhanced Hrp - AEC.............20 slides 290.00
Ultrasensitive Enhanced - Horseradish Peroxidase - DAB Detection
32801-44 PathoGene(R)Assay for Adenovirus / Enhanced Hrp - DAB........................20 slides 290.00
32802-44 PathoGene(R)Assay for Cytomegalovirus / Enhanced Hrp - DAB...................20 slides 290.00
32803-44 PathoGene(R)Assay for ▇▇▇▇▇▇▇-▇▇▇▇ Virus / Enhanced Hrp - DAB................20 slides 290.00
32804-44 PathoGene(R)Assay for Hepatitis B Virus / Enhanced Hrp - DAB.................20 slides 290.00
32805-44 PathoGene(R)Assay for Herpes Simplex Virus / Enhanced Hrp - DAB..............20 slides 290.00
32806-44 PathoGene(R)Assay for Chlamydia trachomatis / Enhanced Hrp - DAB.............20 slides 290.00
- 6 -
IN SITU HYBRIDIZATION ASSAY SYSTEMS (continued)
-------------------------------------------------------------------------------------------------------------------
Cat. No. Product Quantity Price
Ultrasensitive Enhanced - Fluorescent Streptavidin Detection
32801-55 PathoGene(R)Assay for Adenovirus / Enhanced Fl -SA...........................20 slides 290.00
32802-55 PathoGene(R)Assay for Cytomegalovirus / Enhanced Fl -SA......................20 slides 290.00
32803-55 PathoGene(R)Assay for ▇▇▇▇▇▇▇-▇▇▇▇ Virus / Enhanced Fl -SA...................20 slides 290.00
32804-55 PathoGene(R)Assay for Hepatitis B Virus / Enhanced Fl -SA....................20 slides 290.00
32805-55 PathoGene(R)Assay for Herpes Simplex Virus / Enhanced Fl -SA.................20 slides 290.00
32806-55 PathoGene(R)Assay for Chlamydia trachomatis / Enhanced Fl -SA................20 slides 290.00
Ultrasensitive Enhanced - Alkaline Phosphatase - INT / BCIP Detection
32801-66 PathoGene(R)Assay for Adenovirus / Enhanced Alk Phos - INT / BCIP............20 slides 290.00
32802-66 PathoGene(R)Assay for Cytomegalovirus / Enhanced Alk Phos - INT / BCIP.......20 slides 290.00
32803-66 PathoGene(R)Assay for ▇▇▇▇▇▇▇-▇▇▇▇ Virus / Enhanced Alk Phos - INT / BCIP....20 slides 290.00
32804-66 PathoGene(R)Assay for Hepatitis B Virus / Enhanced Alk Phos - INT / BCIP.....20 slides 290.00
32805-66 PathoGene(R)Assay for Herpes Simplex Virus / Enhanced Alk Phos - INT / BCIP..20 slides 290.00
32806-66 PathoGene(R)Assay for Chlamydia trachomatis / Enhanced Alk Phos - INT / BCIP.20 slides 290.00
Ultrasensitive Enhanced - Alkaline Phosphatase - NBT / BCIP Detection
32801-77 PathoGene(R)Assay for Adenovirus / Enhanced Alk Phos - NBT / BCIP............20 slides $290.00
32802-77 PathoGene(R)Assay for Cytomegalovirus / Enhanced Alk Phos - NBT / BCIP.......20 slides 290.00
32803-77 PathoGene(R)Assay for ▇▇▇▇▇▇▇-▇▇▇▇ Virus / Enhanced Alk Phos - NBT / BCIP....20 slides 290.00
32804-77 PathoGene(R)Assay for Hepatitis B Virus / Enhanced Alk Phos - NBT / BCIP.....20 slides 290.00
32805-77 PathoGene(R)Assay for Herpes Simplex Virus / Enhanced Alk Phos - NBT / BCIP..20 slides 290.00
32806-77 PathoGene(R)Assay for Chlamydia trachomatis / Enhanced Alk Phos - NBT / BCIP.20 slides 290.00
PathoGene(R) Tissue Preparation Kit and Control Slides
32800 PathoGene(R)Tissue Preparation Kit........................................20 specimens 145.00
31871 Adenovirus Control Slide.......................................................1 slide 15.00
31872 Cytomegalovirus Control Slide..................................................1 slide 15.00
▇▇▇▇▇ ▇▇▇▇▇▇▇-▇▇▇▇ Control Slide.....................................................1 slide 15.00
31875 Herpes Simplex Virus Control Slide.............................................1 slide 15.00
31876 Chlamydia trachomatis Control Slide............................................1 slide 15.00
31877 HPV 16 Probe Control Slide....................................................1 slide 15.00
ApopDETEK(R) in situ Cell Death Assay Systems
32930 ApopDETEK(R)in situ Cell Death Assay / Hrp - AEC..............................20 slides 175.00
32940 ApopDETEK(R)in situ Cell Death Assay / Hrp - DAB..............................20 slides 175.00
32950 ApopDETEK(R)in situ Cell Death Assay / Fl -SA.................................20 slides 175.00
32960 ApopDETEK(R)in situ Cell Death Assay / Alk Phos - INT / BCIP..................20 slides 175.00
32970 ApopDETEK(R)in situ Cell Death Assay / Alk Phos - NBT / BCIP..................20 slides 175.00
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IN SITU HYBRIDIZATION ASSAY SYSTEMS (continued)
-------------------------------------------------------------------------------------------------------------------
Cat. No. Product Quantity Price
Human Papillomavirus Identification Systems
32881 BioPap(R)Human Papillomavirus in situ Screening Assay for Cervical Smears...20 test kit 345.00
32892 BioPap(R)Human Papillomavirus in situ Typing Assay for
Cervical Specimens (Types 6/11, 16/18 and 31/33/51)..................10 test kit 305.00
32883 BioPap(R)Human Papillomavirus in situ Typing Assay
Cervical Specimen Transport Kit.................................for 10 specimens 35.00
32879 PathoGene(R)Human Papillomavirus in situ Screening Assay for
Tissue Sections .....................................................20 test kit 425.00
32895 PathoGene(R) Human Papillomavirus in situ Typing Assay for
Tissue Sections (Types 6/11, 16/18 and 31/33/51).....................10 test kit 305.00
32877 PathoGene(R)Hrp-AEC Human Papillomavirus in situ Typing Assay fo r
Tissue Sections (Types 6/11, 16/18 and 31/33/51).....................20 test kit 525.00
32874 PathoGene(R)Hrp-DAB Human Papillomavirus in situ Typing Assay for
Tissue Sections (Types 6/11, 16/18 and 31/33/51).....................20 test kit 525.00
In Situ HYBRIDIZATION ASSAY ACCESSORIES
Specimen Slides
31802-20 Pretreated slides / single well..............................................20 slides $25.00
31802-100 Pretreated slides / single well.............................................100 slides 85.00
31803-20 Pretreated slides / double well..............................................20 slides 25.00
31803-100 Pretreated slides / double well.............................................100 slides 85.00
Heating Blocks and Surface Thermometer
31500 Heating Block for use with 110V, 50/60 Hz.......................................1 unit 325.00
31508 Heating Block for use with 220V, 50 Hz..........................................1 unit 325.00
31580 Surface Thermometer.............................................................1 unit 30.00
Biological Reagents and Buffers
33801 Proteinase K..................................................................2 x 5 mg 30.00
33808 In situ Hybridization Buffer (1.25 X concentrate)................................10 ml 25.00
33809 In situ Hybridization Wash Reagent...............................................30 ml 25.00
33802 Enzo Wash Buffer Salts.........................................3 Packets, 1 liter each 15.00
33803 Enzo SignaSure(R)Wash Buffer...................................3 Packets, 1 liter each 25.00
33805 Dilution Buffer for Alkaline Phosphatase-linked Detection Reagents..............100 ml 30.00
33804 Dilution Buffer for Horseradish Peroxidase-linked Detection Reagents............100 ml 30.00
33806 Dilution Buffer for Fluorescence-linked Streptavidin............................100 ml 30.00
33807 Dilution Buffer for Double Antibody Enhancement Procedures......................100 ml 30.00
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BIOPROBE(R) LABELED PROBES
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Cat. No. Product Quantity Price
Infectious Agents
40834 Adenovirus........................................................................2 ug $175.00
40835 Cytomegalovirus...................................................................2 ug 175.00
▇▇▇▇▇ ▇▇▇▇▇▇▇-▇▇▇▇ Virus................................................................2 ug 175.00
40837 Hepatitis B Virus.................................................................2 ug 175.00
40838 Herpes Simples Virus..............................................................2 ug 175.00
▇▇▇▇▇ ▇▇▇▇▇▇▇▇▇ trachomatis.............................................................2 ug 175.00
40842 Hepatitis A Virus.................................................................2 ug 175.00
40843 Mycoplasma pneumonia..............................................................2 ug 175.00
40845 SV40..............................................................................2 ug 175.00
▇▇▇▇▇ ▇▇▇▇▇▇▇▇▇▇▇▇▇ jejuni..............................................................2 ug 175.00
40847 JC Virus..........................................................................2 ug 175.00
40848 BK Virus..........................................................................2 ug 175.00
Oncogenes
40714 c-Ha-ras..........................................................................2 ug 175.00
40717 c-Myc.............................................................................2 ug 175.00
40718 N-Myc.............................................................................2 ug 175.00
Hybridization Controls
40840 Lambda............................................................................2 ug 175.00
40849 Blur 8 (human alu repeat)........................................................2 ug 175.00
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DETEK(R) SIGNAL GENERATING SYSTEMS
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Cat. No. Product Quantity Price
Fluorescent Biotin Detection
43818 DETEK(R)f (Double Antibody Fuorescence Detection).......................for 200 slides $200.00
43821 DETEK(R)FS (Fluorescent Streptavidin Detection)..........................for 100 slides 110.00
DETEK(R) Colorimetric Signal Generating Systems
43820 DETEK(R)Hrp Kit (Hrp - AEC Detection).....................500 ml working solution or 150.00
...........................................................40 membranes (100 cm2 each)
43840 FluorDETEK(R)Hrp Kit (Hrp - AEC Detection)................500 ml working solution or 150.00
...........................................................40 membranes (100 cm2 each)
43822 DETEK(R)Alk Kit (Alk Phos- NBT/BCIP Detection)............500 ml working solution or 200.00
...........................................................40 membranes (100 cm2 each)
43842 FluorDETEK(R)AP Kit (Alk Phos- NBT/BCIP Detection).........500 ml working solution or 200.00
...........................................................40 membranes (100 cm2 each)
- 9 -
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DETEK(R) SIGNAL GENERATING SYSTEMS (continued)
-------------------------------------------------------------------------------------------------------------------
Cat. No. Product Quantity Price
Anti-Biotin Antibody Reagents
43823 DETEK(R)Enhancer Kit (Double Antibody Enhanced Detection).....................30 slides 125.00
43861 Rabbit anti-Biotin Antibody Concentrate........................400 ml working solution 210.00
Colorimetric Signal Generating Reagents
43825 AEC Substrate Kit..............................................300 ml working solution 90.00
43826 DAB Substrate Kit..............................................300 ml working solution 90.00
43827 NBT/BCIP Substrate Kit.........................................400 ml working solution 125.00
43828 INT /BCIP Substrate Kit........................................400 ml working solution 125.00
-------------------------------------------------------------------------------------------------------------------
MICROPLATE HYBRIDIZATION ASSAYS
-------------------------------------------------------------------------------------------------------------------
Cat. No. Product Quantity Price
46330 HIV 1 Microplate Hybridization Assay.......................................96 test kit $625.00
46340 MTB Microplate Hybridization Assay.........................................96 test kit 625.00
46350 HBV (core antigen sequences) Microplate Hybridization Assay...............96 test kit 625.00
46360 HIV 2 Microplate Hybridization Assay.......................................96 test kit 625.00
46380 HBV (surface antigen sequences) Microplate Hybridization Assay.............96 test kit 625.00
46353 Enhanced Microplate Hybridization Assay for Hepatitis B....................96 test kit 700.00
46354 Enhanced Microplate Hybridization Assay for Hepatitis B
Serum Titration Standards.....................4 runs 50.00
46331 Oligonucleotide Pair SK38/SK39..............................................2 x 5 nmol $175.00
46341 Oligonucleotide Pair MTB10/MTB11............................................2 x 5 nmol 175.00
46351 Oligonucleotide Pair HB01/HB02..............................................2 x 5 nmol 175.00
46355 Oligonucleotide Pair HB07/HB08..............................................2 x 5 nmol 175.00
46361 Oligonucleotide Pair VB306/VB310............................................2 x 5 nmol 175.00
46381 Oligonucleotide Pair HB011/HB014............................................2 x 5 nmol 175.00
46382 Oligonucleotide Pair HB012/HB013............................................2 x 5 nmol 175.00
- 10 -
-------------------------------------------------------------------------------------------------------------------
NONOCLONAL ANTIBODIES FOR IMMUNOPATHOLOGY
-------------------------------------------------------------------------------------------------------------------
Product Cat. No. Price Cat. No. Price
Ready-to-Use for Concentrated for
Format 6 ml Format 0.5 ml
anti-Cytokeratin, 35(beta)H11, (low MW, 52.5 kd)........30902 $110.00 34902 $140.00
anti-Cytokeratin, 34(beta)E12 Keratin-903(TM)
(high MW, 68, 58, 56.5, 50 kd)...............30903 110.00 34903 140.00
anti-Cytokeratin, 34(beta)B4, (high MW, 68 kd)..........30904 110.00 34904 140.00
anti-Melanoma, HMB45....................................30930 110.00 34930 140.00
anti-Muscle Actin, HHF35................................30931 110.00 34931 140.00
anti-Neuroendocrine, PHE5...............................30932 110.00 34932 140.00
anti-Smooth Muscle Actin, CGA7..........................30933 110.00 34933 140.00
anti-GFAP...............................................30934 110.00 34934 140.00
anti-Macrophage, HAM56..................................30935 110.00 34934 140.00
- 11 -
EXHIBIT C
Continuing Guaranty
▇▇▇▇▇▇ Healthcare Corporation
▇▇▇▇▇▇▇▇▇, ▇▇▇▇▇▇▇▇ ▇▇▇▇▇-▇▇▇▇
Vendor: Enzo Diagnostics, Inc.
▇▇ ▇▇▇▇▇▇▇▇▇ ▇▇▇▇.
▇▇▇▇▇▇▇▇▇▇▇▇, ▇▇ ▇▇▇▇▇
1. Compliance with Laws: Vendor guarantees that each product shipped to, or on
the order of, ▇▇▇▇▇▇ Healthcare Corporation or any affiliated corporation
("▇▇▇▇▇▇") is as of the date of shipment in compliance with all federal,
state and local laws, regulations, rules and orders.
Vendor specifically guarantees that:
(Equal opportunity statement-required because Baxter is a government
contractor) The products are not manufactured or sold in violation of
any applicable Equal Employment Opportunity requirements, including
those set forth in Section 202 of Executive Order 11246, as amended.
2. Insurance: Vendor agrees to procure and maintain general comprehensive
liability insurance covering each occurrence of bodily injury and property
damage in the amount of not less than One Million Dollars ($1,000,000)
combined single limit (or such higher limits as Baxter shall reasonably
request) with endorsements for product and completed operations, blanket
contractual liability, and vendor's liability. Vendor shall on or before
delivery of first PRODUCT, furnish a certificate of insurance evidencing
the foregoing coverages and limits, stating that the insurer shall give
Baxter written notice at least thirty (30) days prior to any cancellation,
non-renewal or material change in coverage. At ▇▇▇▇▇▇'▇ request, Vendor
will also provide assurance of such insurance.
3. Indemnification: Vendor agrees to indemnify and hold harmless Baxter from
any liability, loss, expense, cost, claim or judgment, arising out of:
a. (Products Liability) Any claim for property damage, or personal
injury or death where the product is alleged to have caused or
contributed to the damage, injury or death. This indemnification
does not extent to injuries, damages or death to the extent caused
by negligence on the part of Baxter or any of its employees or
agents.
b. (Patent infringement) Any claim that the products infringe the
patent, trademark or other proprietary rights of any other party.
4. Recalls: Vendor agrees that it will reimburse Baxter for costs associated
with product corrective actions (including recalls), except those recalls
that result from Baxter negligence.
5. Survival of Guaranty: This guaranty shall be continuing and shall be
binding upon the Vendor and his or its heirs, executors, administrators,
successors and/or assigns and shall inure to the benefit of Baxter, its
successors and assigns and to the benefit of its officers, directors,
agents and employees.
- 1 -
Date:
Corporate Seal Enzo Diagnostics, Inc.
---------------------------------------------------------------
Corporate Name or Name Under Which Business is Conducted
Attect: (If Corporation)
_______________________________________________________________
Signataure & Title of Authorized Officer, Partner or Proprietor
Secretary
_______________________________________________________________
Printed Name & Title of Authorized Officer, Partner of
Proprietor
- 2 -
