August 31.1999 John Mon General Manager Celsion Corporation 10220-1 Old Columbia Road Columbia, MD 21046-1705 Dear John: It was a pleasure speaking with you last week. This letter will confirm that April 9, 1999 is the accurate effective date of the...

                                 EXHIBIT 10.12
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                          Office of Industrial Affairs

                                                                  August 31.1999

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General Manager
Celsion Corporation
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Dear ▇▇▇▇:

It was a pleasure  speaking  with you last week.  This letter will  confirm that
April 9, 1999 is the accurate  effective  date of the Option  Agreement  between
▇▇▇▇▇-▇▇▇▇▇▇▇▇▇  Institute for Cancer Research and Celsion Corporation signed on
February  26,  1999.  The  revised   effective  date  was  agreed  to  during  a
conversation  between  you and  ▇▇▇▇▇  ▇▇▇▇▇▇  in March  but has not been made a
formal  amendment to the agreement.  If Celsion would like a formal amendment to
the option agreement, then we will prepare one. The option period will expire on
November 9, 1999.

Please do not hesitate to contact me if you have any  questions.  I look forward
to our upcoming meeting.


                                                Sincerely,

                                                /s/▇▇▇▇▇▇▇▇ ▇. ▇▇▇▇▇▇
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                                                ▇▇▇▇▇▇▇▇ ▇. ▇▇▇▇▇▇
                                                Licensing Associate


                     Memorial ▇▇▇▇▇-▇▇▇▇▇▇▇▇▇ Cancer Center
                   ▇▇▇▇ ▇▇▇▇ ▇▇▇▇▇▇, ▇▇▇ ▇▇▇▇, ▇▇▇ ▇▇▇▇ ▇▇▇▇▇
                   ▇▇▇-designated Comprehensive Cancer Center