Amendment #3 Consulting Agreement dated October 17, 2016 between ProMIS Neurosciences, Inc. and Danforth Advisors, LLC

Exhibit 10.12.3

Amendment #3

Consulting Agreement dated October 17, 2016 between

ProMIS Neurosciences, Inc. and ▇▇▇▇▇▇▇▇ Advisors, LLC

This Amendment No. 3 to Consulting Agreement (“Amendment”) is made as of August 28, 2018 (“Effective Date”), by and between ProMIS Neurosciences, Inc. (“Company”) and ▇▇▇▇▇▇▇▇ Advisors, LLC (“Consultant” or “▇▇▇▇▇▇▇▇”). Capitalized terms used but not defined herein shall have the respective meaning set forth in the Consulting Agreement by and between ▇▇▇▇▇▇▇▇ Advisors and the Company dated as of October 17, 2016 (“Agreement”).

WHEREAS, ▇▇▇▇▇▇▇▇ is engaged by the Company under the terms and conditions of the Consulting Agreement; and

WHEREAS, the Company and Consultant mutually desire to amend the term and scope of the Agreement.

NOW, THEREFORE, in consideration of the premises and the mutual covenants and agreements herein contained and for the other good and valuable consideration, receipt of which is hereby acknowledge, the parties hereby agree as follows:

1. Section 3. Term and Termination is hereby modified to extend the term of the Agreement until October 17, 2019.

2. Exhibit A, Description of Services and Schedule of Fees, shall be hereby modified to:

· Add ▇▇▇▇ ▇▇▇▇▇▇▇ as a Controller Consultant at an hourly rate of $155/hour. The Services to be provided are more fully described in Exhibit A-3.

3. Except as specifically provided for in this Amendment, the terms of the Agreement shall be unmodified and shall remain in full force and effect.

This Amendment may be executed in one or more counterparts, each of which shall be considered an original instrument, but all of which shall be considered one and the same Amendment, and shall become binding when one or more counterparts have been signed by each of the parties and delivered to the other.

IN WITNESS WHEREOF, this Amendment has been executed by the Company and ▇▇▇▇▇▇▇▇ Advisors, LLC to be effective as of the date first above written.

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▇▇▇▇▇▇▇▇ ADVISORS, LLC			PROMIS NEUROSCIENCES, INC.
By:	/s/ ▇▇▇▇▇ ▇▇▇▇▇▇		By:	/s/ ▇▇▇▇▇▇ ▇▇▇▇▇▇▇▇
Print Name:      ▇▇▇▇▇ ▇▇▇▇▇▇			Print Name:      ▇▇▇▇▇▇ ▇▇▇▇▇▇▇▇
Title:   Managing Director			Title:   Executive Chairman
Date:			Date:    8/31/18

2

EXHIBIT A-3

Description of Additional Services

[Intentionally Omitted]