1 EXHIBIT 10.8 Amendment Four to Consulting Agreement WHEREAS, this Amendment Four to Consulting Agreement is effective July 1, 2000, and is made between NEORX CORPORATION, 410 West Harrison Street, Seattle, Washington 98119, and DR. FRED CRAVES, 215...

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                                                                    EXHIBIT 10.8

                     Amendment Four to Consulting Agreement

        WHEREAS, this Amendment Four to Consulting Agreement is effective July
1, 2000, and is made between NEORX CORPORATION, 000 Xxxx Xxxxxxxx Xxxxxx,
Xxxxxxx, Xxxxxxxxxx 00000, and DR. XXXX CRAVES, 000 Xxxxxx Xxxxx, Xxxxxxxxx,
Xxxxxxxxxx 00000; and

        WHEREAS, the parties are desirous of extending the term of said
Consulting Agreement.

        NOW, THEREFORE, the term of the Agreement shall be extended to December
31, 2000.

        All other terms and conditions of the original Consulting Agreement as
amended shall remain in full force and effect, as stated.

                                              NeoRx Corporation

                                              By: /s/ XXXX X. XXXXXX
                                                  ------------------------------
                                                      Xxxx X. Xxxxxx, M.D., X.X.
                                                      Chief Executive Officer


                                              /s/ XXXX X. CRAVES
                                              ----------------------------------
                                              Xxxx X. Craves, Ph.D.