AMENDMENT NO. 02 Dated September 11, 2006 TO that certain Loan and Security Agreement No. 4611 dated as of March 21, 2005, as amended ("Agreement"), by and between LIGHTHOUSE CAPITAL PARTNERS V, L.P. ("Lender") and NOVACARDIA, INC. ("Borrower").

Exhibits 10.23

         AMENDMENT NO. 02

Dated September 11, 2006

TO

that certain Loan and Security Agreement No. 4611
dated as of March 21, 2005, as amended ("Agreement"), by and between
LIGHTHOUSE CAPITAL PARTNERS V, L.P. ("Lender") and
NOVACARDIA, INC. ("Borrower").

(All capitalized terms not otherwise defined herein shall have the meanings given to such terms in the Agreement.)

Without limiting or amending any other provisions of the Agreement, Lender and Borrower agree to the following:

The following definition shall be deleted in its entirety and replaced with the following:

        "Bridge Loan Commitment Termination Date" means September 22, 2006.

Except as amended hereby, the Agreement remains unmodified and unchanged.

BORROWER:				LENDER:
NOVACARDIA, INC.				LIGHTHOUSE CAPITAL PARTNERS V, L.P.
				By:		LIGHTHOUSE MANAGEMENT PARTNERS V, L.L.C., its general partner
By:		/s/  XXXXXXX X. XXXXX		By:		/s/  XXXXXX XXXXXXXX
Name:		Xxxxxxx X. Xxxxx		Name:		Xxxxxx Xxxxxxxx
Title:		President and CEO		Title:		Vice President