Lexicon Pharmaceuticals, Inc./De Sample Contracts

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1 EXHIBIT 10.12 PARTICIPATION AGREEMENT Dated as of October 19, 2000
Lease Agreement • March 15th, 2001 • Lexicon Genetics Inc/Tx • Services-commercial physical & biological research • North Carolina
BY AND AMONG
Agreement and Plan of Merger • June 18th, 2001 • Lexicon Genetics Inc/Tx • In vitro & in vivo diagnostic substances • Delaware
EXHIBIT 1.1 LEXICON GENETICS INCORPORATED [ ] Shares of Common Stock Underwriting Agreement
Lexicon Genetics Inc/Tx • April 5th, 2000 • Services-commercial physical & biological research • New York
WITNESSETH:
Registration Rights Agreement • August 10th, 2001 • Lexicon Genetics Inc/Tx • In vitro & in vivo diagnostic substances • Delaware
AGREEMENT
Agreement • April 6th, 2000 • Lexicon Genetics Inc/Tx • Services-commercial physical & biological research • New Jersey
19,894,076 Shares LEXICON PHARMACEUTICALS, INC. COMMON STOCK, PAR VALUE $0.001 PER SHARE UNDERWRITING AGREEMENT
Underwriting Agreement • October 9th, 2009 • Lexicon Pharmaceuticals, Inc./De • Pharmaceutical preparations • New York

The undersigned understands that Morgan Stanley & Co. Incorporated (“Morgan Stanley”) proposes to enter into an Underwriting Agreement (the “Underwriting Agreement”) with Lexicon Pharmaceuticals, Inc., a Delaware corporation (the “Company”), providing for the public offering (the “Public Offering”) by the several Underwriters, including Morgan Stanley (the “Underwriters”), of shares (the “Shares”) of the common stock, par value $0.001 per share, of the Company (the “Common Stock”).

SECOND AMENDED AND RESTATED COLLABORATION AND LICENSE AGREEMENT
Note Agreement • March 3rd, 2006 • Lexicon Genetics Inc/Tx • In vitro & in vivo diagnostic substances • Delaware
OPEN MARKET SALE AGREEMENTSM
Lexicon Pharmaceuticals, Inc. • December 29th, 2023 • Pharmaceutical preparations • New York
WITNESSETH:
Employment Agreement • March 3rd, 2006 • Lexicon Genetics Inc/Tx • In vitro & in vivo diagnostic substances • Texas
LOAN AND SECURITY AGREEMENT
Loan and Security Agreement • May 5th, 2022 • Lexicon Pharmaceuticals, Inc. • Pharmaceutical preparations

This LOAN AND SECURITY AGREEMENT (as the same may from time to time be amended, modified, supplemented or restated, this “Agreement”) dated as of March 17, 2022 (the “Effective Date”) among OXFORD FINANCE LLC, a Delaware limited liability company with an office located at 115 South Union Street, Suite 300, Alexandria, VA 22314 (“Oxford”), as collateral agent (in such capacity, “Collateral Agent”), the Lenders listed on Schedule 1.1 hereof or otherwise a party hereto from time to time including Oxford in its capacity as a Lender and OXFORD FINANCE CREDIT FUND III, LP, by its manager Oxford Finance Advisors, LLC (“Credit Fund”; each a “Lender” and collectively, the “Lenders”), LEXICON PHARMACEUTICALS, INC. (“Parent”) and LEXICON PHARMACEUTICALS (NEW JERSEY), INC. (“Lex-NJ”), each a Delaware corporation with offices located at 2445 Technology Forest Blvd., 11th Floor, The Woodlands, TX 77381 (Parent and Lex-NJ, individually and collectively, jointly and severally, “Borrower”), provides th

RECITALS
Collaboration and License Agreement • November 1st, 2005 • Lexicon Genetics Inc/Tx • In vitro & in vivo diagnostic substances • Texas
LEXICON PHARMACEUTICALS, INC. 23,924,705 Shares Common Stock ($0.001 par value) Underwriting Agreement
Lexicon Pharmaceuticals, Inc. • June 2nd, 2023 • Pharmaceutical preparations • New York
17,500,000 Shares LEXICON PHARMACEUTICALS, INC. COMMON STOCK, PAR VALUE $0.001 PER SHARE UNDERWRITING AGREEMENT
Underwriting Agreement • October 19th, 2012 • Lexicon Pharmaceuticals, Inc./De • Pharmaceutical preparations • New York

The undersigned understands that J.P. Morgan Securities LLC (“J.P. Morgan”) and Jefferies & Company, Inc. (“Jefferies”) propose to enter into an Underwriting Agreement (the “Underwriting Agreement”) with Lexicon Pharmaceuticals, Inc., a Delaware corporation (the “Company”), providing for the public offering (the “Public Offering”) by the several Underwriters, including J.P. Morgan and Jefferies (the “Underwriters”), of shares (the “Shares”) of the common stock, par value $0.001 per share, of the Company (the “Common Stock”).

BY AND BETWEEN
Collaboration Agreement • November 2nd, 2004 • Lexicon Genetics Inc/Tx • In vitro & in vivo diagnostic substances • New York
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EXHIBIT 1.1
Lexicon Genetics Inc/Tx • October 23rd, 2006 • In vitro & in vivo diagnostic substances • New York
REAL ESTATE PURCHASE AND SALE AGREEMENT BETWEEN LEX-GEN WOODLANDS, L.P. AND Nurix Therapeutics, Inc. CONCERNING PROPERTY COMMONLY KNOWN AS 8800 TECHNOLOGY FOREST PLACE IN THE WOODLANDS, TEXAS
Real Estate Purchase and Sale Agreement • October 22nd, 2020 • Lexicon Pharmaceuticals, Inc. • Pharmaceutical preparations • Texas

This instrument was acknowledged before me on ___________, 20__, by _____________________, __________________________ of Lex-Gen Woodlands GP, LLC, a Delaware limited liability company, sole general partner of Lex-Gen Woodlands, L.P., a Delaware limited partnership, on behalf of said limited partnership.

RESTRICTED STOCK UNIT AGREEMENT
Restricted Stock Unit Agreement • March 25th, 2024 • Lexicon Pharmaceuticals, Inc. • Pharmaceutical preparations • Delaware

This Restricted Stock Unit Agreement (this “Agreement”), effective as of ____________ (the “Grant Date”), is by and between Lexicon Pharmaceuticals, Inc., a Delaware corporation (the “Company”), and _____________ (“Employee”).

LEASE
Lease • March 25th, 2002 • Lexicon Genetics Inc/Tx • In vitro & in vivo diagnostic substances
LEXICON PHARMACEUTICALS, INC. AND WELLS FARGO BANK, NATIONAL ASSOCIATION, as Trustee INDENTURE Dated as of November 26, 2014 5.25% Convertible Senior Notes due 2021
Indenture • November 28th, 2014 • Lexicon Pharmaceuticals, Inc./De • Pharmaceutical preparations • New York

INDENTURE dated as of November 26, 2014 between Lexicon Pharmaceuticals, Inc., a Delaware corporation, as issuer (the “Company,” as more fully set forth in Section 1.01) and Wells Fargo Bank, National Association, a national banking association, as Trustee (the “Trustee,” as more fully set forth in Section 1.01).

EXHIBIT 10.18 LOAN AND SECURITY AGREEMENT
Loan and Security Agreement • March 14th, 2005 • Lexicon Genetics Inc/Tx • In vitro & in vivo diagnostic substances • New York
STOCK OPTION AGREEMENT (Officer Incentive Stock Option)
Stock Option Agreement • March 1st, 2018 • Lexicon Pharmaceuticals, Inc. • Pharmaceutical preparations • Delaware

THIS STOCK OPTION AGREEMENT (this “Agreement”), effective as of __________ (the “Grant Date”), is by and between LEXICON PHARMACEUTICALS, INC., a Delaware corporation (the “Company”), and _____________ (“Optionee”).

RECITALS
Database Access Agreement • March 1st, 2000 • Lexicon Genetics Inc/Tx • Services-commercial physical & biological research • Delaware
RECITALS
Sublicense Agreement • July 16th, 2004 • Lexicon Genetics Inc/Tx • In vitro & in vivo diagnostic substances • Delaware
RESTRICTED STOCK UNIT AGREEMENT (Officer Restricted Stock Unit)
Restricted Stock Unit Agreement • March 11th, 2013 • Lexicon Pharmaceuticals, Inc./De • Pharmaceutical preparations • Delaware

This Restricted Stock Unit Agreement (this “Agreement”), effective as of February ___, 20__ (the “Grant Date”), is by and between Lexicon Pharmaceuticals, Inc., a Delaware corporation (the “Company”), and ________________ (“Employee”).

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