Urine Sample Clauses

Urine. High resolution protein electrophoresis is an excellent analytical technique to gain a broad overview of urine proteins.3,8 Glomerular-typed proteinuria, tubular-type proteinuria as well as mixed glomerular-tubular patterns and the various overflow states can be easily distinguished and characterized, thus providing useful information on specific functions within the nephron. CSF Oligoclonal immunoglobulin patterns can be seen in both serum and cerebrospinal fluid as faint bands in the gamma zone. They are usually multiple homogeneous, narrow and discrete in appearance. When seen in serum, the bands indicate the presence of immune complexes which are associated with Xxxxxxxx disease or a non-specific early immune response to various disease states. In the cerebrospinal fluid their presence is supportive evidence for the diagnosis of multiple sclerosis (MS) in the proper clinical setting. Oligoclonal bands in serum are not indicative of MS. An oligoclonal pattern in the CSF is present in more than 90% of MS patients at some time during the course of the disease. It may be less sensitive during an initial attack and is not completely specific for MS. High resolution protein electrophoresis is less sensitive than isoelectric focusing with IgG immunoblotting for detection of oligoclonal bands. Other diseases associated with an oligoclonal pattern include subacute sclerosing panencephalitis and some infections of the central nervous system.13,14 BIBLIOGRAPHY
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