Common use of Serum Clause in Contracts

Serum. High resolution protein electrophoresis patterns are primarily interpreted by comparing the relative intensities of the bands obtained on unknown specimens with those obtained on known normal individuals. One of the most common abnormal serum protein patterns is that observed in the non-specific inflammatory response which is characterized by an increase in α1-antitrypsin and haptoglobin with decreased prealbumin, albumin and transferrin. While it is not useful in establishing a general diagnosis, it is useful in monitoring a patient’s response to therapy. Other examples of clinically important variations are: - elevation of the transferrin band, suggesting a low level of iron - presence of monoclonal proteins, suggesting abnormalities of the immune system - low haptoglobin, suggesting elevated RBC turnover or in-vitro hemolysis - CRP presence, indicating an acute inflammatory response - low prealbumin, albumin and transferrin with diffuse hypergammaglobulinemia, suggesting chronic inflammation, infection or antigenic stimulation - low C3 on fresh samples, suggesting complement consumption.

Serum. High resolution protein electrophoresis patterns are primarily interpreted by comparing the relative intensities of the bands obtained on unknown specimens with those obtained on known normal individuals. One of the most common abnormal serum protein patterns is that observed in the non-specific inflammatory response which is characterized by an increase in α1a1-antitrypsin and haptoglobin with decreased prealbumin, albumin and transferrin. While it is not useful in establishing a general diagnosis, it is useful in monitoring a patient’s response to therapy. Other examples of clinically important variations are: - elevation of the transferrin band, suggesting a low level of iron - presence of monoclonal proteins, suggesting abnormalities of the immune system - low haptoglobin, suggesting elevated RBC turnover or in-vitro hemolysis - CRP presence, indicating an acute inflammatory response - low prealbumin, albumin and transferrin with diffuse hypergammaglobulinemia, suggesting chronic inflammation, infection or antigenic stimulation - low C3 on fresh samples, suggesting complement consumption.