Rationale for Adding Niacin Sample Clauses

Rationale for Adding Niacin. NAD can be generated by catabolism of tryptophan, salvage of nicotinamide through NAMPT or salvage of exogenous niacin through NAPRT1. Some cancers lack the enzyme(s) necessary for the de novo synthesis of NAD from tryptophan, while NAPRT1 (a niacin utilizing enzyme) activity is frequently down-regulated by epigenetic modulation or IDH1 mutation leaving these cancers dependent on NAMPT activity. If tumors have reduced or absent NAPRT1 function, then this tissue may not be able to utilize niacin to make NAD. Therefore, patients with NAPRT1 in normal tissue, but not in their tumors, might benefit from a niacin co-dosing strategy in order to reduce ‌ Investigational Product (KPT-9274) Karyopharm Therapeutics Inc. Clinical Study Protocol: KCP-9274-901 11 March 2020‌‌‌‌