Primary Screen Sample Clauses
Primary Screen. Fulcrum will conduct the Primary Screen on each Potential Project Gene for the purpose of identifying one or more Screened Targets that modulate such Potential Project Gene. Within [**] after completion of such Primary Screen, Fulcrum will furnish a data package to the JSC that will contain the information described in paragraph 4(d) of the Research Plan for [**] Potential Project Genes, including the [**] (the “Primary Screen Data Package”) [**]. The JSC, in accordance with Article 2 (Collaboration Management), will review the Primary Screen Data Package. The JSC also may request, and Fulcrum will provide [**].
Primary Screen. All libraries will be screened at a single dose (10‐50uM, Users should justify if they wish higher concentration). The general order of library screening is pilot screen (using NIH clinical collection (446 cpds) and Spectrum collection (2,000 cpds)), followed by the full TI3D library screen (~30k commercial cpds). However, Users can select libraries. Users provide preliminary definition of “Hit” criteria, for example Inhibition % or activation %, Intensity >50%, etc. Users can analyze data by themselves but should send to HTAF director to be uploaded to database with appropriate format. The HTAF will perform quality control (QC) tests for assay plates, identify hits, and provide a summary of that report to Users. The HTAF staff assists Users to re‐supply compounds for assay validation.