PolNet Clause Samples
PolNet. PolNet is a software tool for the computer simulation of blood flow in realistic microvascular networks imaged with a wide variety of microscopy and clinical imaging techniques. To date, PolNet has contributed to: a) uncovering the relationship between blood flow and blood vessel biology and its importance for correct vascularisation of tissues, and b) developing ways of predicting retinal vascular damage in diabetic retinopathy patients. PolNet facilitates the adoption of cutting-edge computer simulation technology by non-experts in the Biosciences.
PolNet. PolNet is a software tool for the computer simulation of blood flow in realistic microvascular networks imaged with a wide variety of microscopy and clinical imaging techniques. To date, PolNet has contributed to: a) uncovering the relationship between blood flow and blood vessel biology and its importance for correct vascularisation of tissues, and b) developing ways of predicting retinal vascular damage in diabetic retinopathy patients. PolNet facilitates the adoption of cutting-edge computer simulation technology by non-experts in the Biosciences. Regarding scaling, PolNet is, essentially, a portal which extends the functionality of HemeLB. Previous versions ran these extended HemeLB calculations on the end users’ workstation. CompBioMed has now extended PolNet’s functionality to seamlessly run massive extended HemeLB on remote HPC resources, via interactions with the remote batch system. As such, PolNet scales as HemeLB scales.
PolNet. PolNet is a software tool for the computer simulation of blood flow in realistic microvascular networks imaged with a wide variety of microscopy and clinical imaging techniques. To date, PolNet has contributed to, a) uncovering the relationship between blood flow and blood vessel biology and its importance for correct vascularisation of tissues, and b) developing ways of predicting retinal vascular damage in diabetic retinopathy patients. PolNet facilitates the adoption of cutting-edge computer simulation technology by non-experts in the Biosciences. PolNet provides a complete workflow for image processing, three-dimensional vascular network reconstruction, and blood flow simulation with the HemeLB software. In addition, it provides tools for studying the relationship between the flow simulated and cellular/molecular readouts quantified in the same images. To date, PolNet has contributed to establishing the relationship between blood flow and endothelial cell polarisation and migration during vascular development. In addition, PolNet is being used to develop novel methods for the prediction of sight-threatening complications in diabetic retinopathy. PolNet uses the Docker platform to facilitate deployment in experimental biology laboratories and hospitals. PolNet allows execution of HemeLB simulations in both commodity software and High Performance Computing resources. Ongoing work is aimed at enabling HemeLB execution in Cloud resources. Non-clinical research ✔ Clinical research ✔ Drug discovery Design & optimisation Personal health forecasting Contact email: ▇▇▇▇▇▇.▇▇▇▇▇▇▇▇@▇▇.▇▇.▇▇ Estimated users at M24: 0 Estimated users at M36: 9 End user name ▇▇▇▇▇▇▇ ▇. ▇▇▇▇▇▇’▇ group ▇▇▇▇▇▇ ▇▇▇▇▇▇▇▇’▇ group ▇▇▇▇▇▇▇▇ ▇. ▇▇▇’s group Affiliation Instituto de Medicine Molecular, University of Lisbon ▇▇▇ ▇▇▇▇▇▇▇▇ Center for Molecular Medicine, Berlin ▇▇▇▇▇▇ Diabetes Center, Harvard University Application area Developmental vascular biology Developmental vascular biology Ophthalmology research No. of associated users 3 3 3 Target use Research Research Research Improvements implemented Remote cloud execution Remote cloud execution Impact Papers Papers Papers Use of any e- infrastructure available via CompBioMed EPCC EPCC EPCC