Hardness. The vitamin A soft gelatin capsules procured by NI and UNICEF are used in public health programs worldwide. Unlike other preparations, the soft gelatin capsule is used in this case as a dropper to deliver its liquid contents directly into the recipient’s mouth. The capsule is not swallowed. To allow for optimal use of vitamin A soft gelatin capsules in the field, the capsule shell must be hard enough to withstand hot and humid conditions (i.e. not leaking or clumping with other capsules) but soft enough to be used as a dropper such that the entire liquid contents of the capsule can be squeezed gently into the child’s mouth with ease by health workers even while dosing numerous children in sequence during campaigns. In addition capsules must not be brittle (i.e. breaking or cracking at the seal when squeezed). In light of these considerations, manufacturers must set their own hardness limits (i.e. minimum and maximum) for (i) stability trials and (ii) point of release as measured by a ▇▇▇▇▇▇▇ Hardness Tester, or equivalent. CAPSULE CONTENTS
Appears in 2 contracts
Sources: Long Term Agreement for Goods, Long Term Agreement for Goods