Experimental. INVESTIGATIVE - the use of any treatment, Service, procedure, facility, equipment, drug, device or supply (intervention) which is not determined by the Plan to be medically effective for the condition being treated. The Plan will consider an intervention to be Experimental/Investigative if:
Experimental. Shall be defined as all procedures and treatments not covered under the Medicare Program (Title XVlll of Social Security Act of 1965, as amended), unless otherwise specifically included or excluded under this Agreement.
Experimental. Materials and reagents 2,2´-azobispyridine (apy), Ru(tpy)Cl3, [Ru(apy)(tpy)Cl](ClO4), [Ru(apy)(tpy)(H2O)](ClO4)2·2H2O and [Ru(apy)(tpy)(CH3CN)](ClO4)2 were synthesized according to the literature methods.21-23 LiCl, NaClO4 (both Merck), NaClO, AgNO3 (both Acros), tpy (Aldrich), RuCl3·3H2O (Johnson & Matthey), and 9-EtGua (Sigma) were used as supplied. All other chemicals and solvents were reagent grade commercial materials and used as received. Physical measurements C, H and N determinations were performed on a Perkin Elmer 2400 Series II analyzer. Mass spectra were obtained with a Finnigan Aqa mass spectrometer equipped with an electrospray ionization source (ESI). FTIR spectra were obtained on a Perkin Elmer Paragon 1000 FTIR spectrophotometer equipped with a Golden Gate ATR device, using the diffuse reflectance technique (res. 4 cm-1). NMR spectra were recorded on a Bruker DPX-300 spectrometer operating at a frequency of 300 MHz, at a temperature of 310 K; on a Bruker Avance-400, at a frequency of 400 MHz and 328 K, and on a Bruker DRX-500 spectrometer operating at a frequency of 500 MHz, at a variable temperature. Chemical shifts were calibrated against tetramethylsilane (TMS). [Ru(apy)(tpy)(9-EtGua)]2+ titration The pH titrations were carried out at 310 K in D2O, by adjustments with DCl and NaOD without the use of any buffer. The pH values were not corrected for the H/D isotope effect. The pH meter was calibrated with Fisher certified buffer solutions of pH 4.00, 7.00 and 10.00. Synthesis and characterization of [Ru(apy)(tpy)(9-EtGua)](ClO4)2 [Ru(apy)(tpy)(H2O)](ClO4)2·2H2O (15 mg, 0.019 mmol) and 9-EtGua (4 mg, 0.022 mmol) were vigorously refluxed in 5 mL EtOH abs for 24 hours. The mixture was left to cool down to r.t. The product was collected by filtration, washed with a small amount (about 2 mL) of ice-cold water and ether and dried in vacuo over silica (yield 82%). C32H28N12O9Cl2Ru (%) calcd C, 42.9; H, 3.1; N, 18.7. Found: C, 42.7; H, 2.7; N, 18.8. ESI- MS: m/z 697.1 ([Ru(apy)(tpy)(9-EtGua - H)]+); 348.7 ([Ru(apy)(tpy)(9-EtGua)]2+). 1H NMR (300 MHz, D2O, 310 K): δ (ppm)= 9.21 (d, 1H, 5.20 Hz); 8.92 (d, 1H, 8.22 Hz); 8.48 (t, 1H, 8.00 Hz); 8.37 (m, 3H); 8.20 (t, 1H, 8.06 Hz); 8.11 (m, 3H); 7.92 (d, 1H, 4.99 Hz); 7.64 (m, 3H); 7.41 (dd, 2H, J1 = 8.70 Hz, J2 = 14.92 Hz); 7.30 (dd, 1H, J1 = 4.28 Hz, J2 = 6.86 Hz); 6.81 (s, 1H); 6.52 (d, 1H, 7.98 Hz); 3.83 (dd, 2H, J1 = 7.21 Hz, J2 = 14.47 Hz);
Experimental. The Seebeck coefficient was measured using a home-made sample holder built on a PPMS puck. It consists of two copper blocks separated by a thermal insulator plastic. The copper has a high thermal conductance so the blocks are at a uniform temperature while a temperature gradient is produced be- tween them. A small heater (maximum power of 5 W) is installed in the upper block. Its temperature is measured with a Pt-100 resistor and controlled with an external temperature controller. The temperature of the lower block is controlled by the set point of the PPMS, but the temperature was separately measured by a second Pt-100 resistor. The whole setup is covered with a stainless steal cup that isolates the sample holder to help stabilize the tem- perature gradient. The measurements were done in a relatively low vacuum of 10 mTorr. A schematic of the sample holder is given in Fig.6.1 The samples consisted of thin films, mostly on sapphire substrates, with an area of 10 × 10 mm2. CrO2 films were deposited by Chemical Vapor Deposition (CVD) on both isostructural TiO2(100) and sapphire (1000) sub- strates. CrO2 films deposit epitaxially on TiO2 in the form of rectangular grains aligned along c-axis but on sapphire the grains are aligned with six fold rotational symmetry coming from the hexagonal structure of the substrate, as detailed in Chapter 3. The Py thin films were deposited using dc sputter- ing in a UHV sputtering system, with a base pressure of 10−9 mbar, the Co films were deposited in Z-400 an RF sputtering system with base pressure of 10−6 mbar. Both Py and Co were deposited on sapphire substrates because of its better thermal conductivity. The Seebeck coefficient was recorded with reference to copper since Cu wires were connected at both ends of the film via pressed Indium. The po- tential difference was probed using a Nanovoltmeter (Xxxxxxxx 2018) in an open circuit geometry (J = 0). A dynamic technique was utilized to measure TEM as function of temperature in which the temperature difference between hot and cold point was always 5 K, while the temperature of the cold point was increased by 10 K in each step. In this way hot point and cold point interchanged in each step between the temperature range of 100 - 400 K [80]. To check the setup, TEP was measured for nonmagnetic Cu, Au, and Pt with reference to Cu. In principal, it should give a zero TEP on a Cu thin film, but we measured around 2.5 µV at temperature difference of 45 K with the hot terminal b...
Experimental. PLAN The experimental details that follow are approximate and may be changed upon mutual agreement of the NCI and Kite. Any change in the scope of this CRADA will be by mutual consent and written Amendment to the CRADA. […***…]. […***…]. ***Confidential Treatment Requested PHS ICT-CRADA Case Ref. No. MODEL ADOPTED June 18, 2009 Page 28 of 52 Confidential PUBLIC HEALTH SERVICE COOPERATIVE RESEARCH AND DEVELOPMENT AGREEMENT FOR INTRAMURAL-PHS CLINICAL RESEARCH […***…]. ***Confidential Treatment Requested PHS ICT-CRADA Case Ref. No. MODEL ADOPTED June 18, 2009 Page 29 of 52 Confidential PUBLIC HEALTH SERVICE COOPERATIVE RESEARCH AND DEVELOPMENT AGREEMENT FOR INTRAMURAL-PHS CLINICAL RESEARCH […***…]. ***Confidential Treatment Requested PHS ICT-CRADA Case Ref. No. MODEL ADOPTED June 18, 2009 Page 30 of 52 Confidential PUBLIC HEALTH SERVICE COOPERATIVE RESEARCH AND DEVELOPMENT AGREEMENT FOR INTRAMURAL-PHS CLINICAL RESEARCH […***…]. ***Confidential Treatment Requested PHS ICT-CRADA Case Ref. No. MODEL ADOPTED June 18, 2009 Page 31 of 52 Confidential PUBLIC HEALTH SERVICE COOPERATIVE RESEARCH AND DEVELOPMENT AGREEMENT FOR INTRAMURAL-PHS CLINICAL RESEARCH […***…]. ***Confidential Treatment Requested PHS ICT-CRADA Case Ref. No. MODEL ADOPTED June 18, 2009 Page 32 of 52 Confidential PUBLIC HEALTH SERVICE COOPERATIVE RESEARCH AND DEVELOPMENT AGREEMENT FOR INTRAMURAL-PHS CLINICAL RESEARCH […***…]. ***Confidential Treatment Requested PHS ICT-CRADA Case Ref. No. MODEL ADOPTED June 18, 2009 Page 33 of 52 Confidential PUBLIC HEALTH SERVICE COOPERATIVE RESEARCH AND DEVELOPMENT AGREEMENT FOR INTRAMURAL-PHS CLINICAL RESEARCH […***…]. ***Confidential Treatment Requested PHS ICT-CRADA Case Ref. No. MODEL ADOPTED June 18, 2009 Page 34 of 52 Confidential PUBLIC HEALTH SERVICE COOPERATIVE RESEARCH AND DEVELOPMENT AGREEMENT FOR INTRAMURAL-PHS CLINICAL RESEARCH […***…]. DESCRIPTION OF THE CONTRIBUTIONS AND RESPONSIBILITIES OF THE PARTIES Surgery Branch, NCI — […***…]. ***Confidential Treatment Requested PHS ICT-CRADA Case Ref. No. MODEL ADOPTED June 18, 2009 Page 35 of 52 Confidential PUBLIC HEALTH SERVICE COOPERATIVE RESEARCH AND DEVELOPMENT AGREEMENT FOR INTRAMURAL-PHS CLINICAL RESEARCH — […***…]. Kite Pharma, Inc. — […***…]. NCI Surgery Branch and Kite Pharma, Inc. — […***…]. ***Confidential Treatment Requested PHS ICT-CRADA Case Ref. No. MODEL ADOPTED June 18, 2009 Page 36 of 52 Confidential PUBLIC HEALTH SERVICE COOPERATIVE RESEARCH AND DEVELOPMENT AGREEMENT FOR INTRAMURAL-PHS ...
Experimental. Samples consisted of single crystals of Ac, doped with DBT. The sample preparation, as well as the home-built confocal microscope used for the single- molecule study have been described in Chapter 3. We performed temperature-dependent measurements on the system, in the range of 1.4 to 4.0 K, monitoring the temperature with a calibrated resistor (Cernox Resistor CX-1050-AA-1.4L, LakeShore, Westerville, OH). It has to be pointed out that our bath cryostat did not allow us to independently vary temperature and pressure. The orientation of the crystallographic axes ’a’ and ’b’ of the Ac crystals were determined by a polarisation transmission measurement, rotating the polarisation of the incident light and recording the minimum intensity trans- mitted by an analyser placed behind the crystal. A reflection measurement allowed us to distinguish between the ’a’ and ’b’ axes. The Stark coefficients were recorded by applying high voltages (from -3000 to 3000 V), with a crystal carefully placed in between two copper electrodes, with a spacing of 3 mm. The Stark cell had been designed so as to avoid any contact between the crystal and the electrodes in order to rule out any charge injection effects. The electric field was applied in the (a,b) plane of the Ac crystal, with an angle of 60◦ with respect to the ’b’ axis.
Experimental. This section first describes a situation whereby two printing devices belong to two different color reproduction workflows. The output of the first workflow is the press sheet that serves as the reference. The output of the second workflow is the proof that serves as the sample. Sample proofs need to match the press sheet closely by means of different image adjustment methods. This section then describes input materials and equipment used in the experiment. This is followed by various color image adjustment procedures. Two Color Reproduction Workflows To explore various options in achieving color agreement between two dissimilar color printing devices, we consider the following two workflows: publishing and proofing. As shown in the top row of Figure 1, the publishing workflow involves the conversion of RGB images to the press CMYK space plus printing these images under calibrated press conditions. The press sheet (CMYK1) represents the reference.
Experimental. Single crystals of Ba(Fe1-‐xCox)2As2 were grown by a self-‐flux method as described elsewhere.7 The superconducting Tc is 22.5 K, and wavelength dispersive spectroscopy shows that x = 0.074, making this an optimally doped sample. In Ref. 4 Xxx and collaborators used a TDR to obtain global measurements of the temperature-‐induced change of the in-‐plane London penetration depth. The technique is described in Ref. 4 and references therein. In this work, we report local penetration depth measurements performed on the same sample. The sample was primarily stored in a desiccator, but was exposed to atmosphere during shipment and cooldown. No additional cleaving was performed and the sample was measured as received after TDR measurements, which occurred 30 months prior. We use a scanning superconducting quantum interference device susceptometer (SSS) to measure the local diamagnetic response of the sample at three locations, as described previously.8 The temperature-‐induced changes in diamagnetic response can be converted to changes in penetration depth by the scanner calibration constant, which dominates our 7% systematic uncertainty in Δλab(T).8 By repeating the SSS measurement at different locations on the same sample, we can observe any large scale inhomogeneity (>100 µm) in the sample, if it is present. To account for a slow, irreproducible drift in the measurement, we report data that re-‐traces itself on sweeping the temperature up and down.
Experimental. The parties have agreed that it is in their mutual interest to establish a new Internet provision as described below. In doing so, the parties recognize that the Internet as an advertising medium is still in its early stage of development. Accordingly, this provision is entered into on an experimental basis with the expectation and understanding that the parties will continue to assess such Internet development during the term of this Agreement with a view toward making such changes as are mutually beneficial in the next round of collective bargaining. Upon the request of either party, the parties will hold a Joint Industry-Federation Committee meeting during the term of this Agreement to discuss Internet-related issues.
Experimental. The preparation of uniformly labeled self-aggregated Chl a/H2O has been described before [1]. The measurements were performed with a DSX-750 spectrometer and using a 4 mm triple resonance probe (Bruker, Germany), operating at a temperature of 277 K. The spinning frequency was kept constant within a few Hertz. During the 13C evolution intervals, heteronuclear TPPM decoupling [16] was applied with pulses of 7.3 μs and a phase modulation of 15°, using a rf nutation frequency of 66 kHz. Phase sensitive detection in the t1 dimension was achieved with a TPPI scheme [17].
