Common use of Enzyme Clause in Contracts

Enzyme. The enzyme is [**]. The Partner Territory consists of the 27 members of the European Union as of the date of this Agreement, specifically Austria, Belgium, Bulgaria, Cyprus, Czech Republic, Denmark, Estonia, Finland, France, Germany, Greece, Hungary, Ireland, Italy, Latvia, Lithuania, Luxembourg, Malta, The Netherlands, Poland, Portugal, Romania, Slovakia, Slovenia, Spain, Sweden and the UK, and Croatia, Albania, Armenia, Azerbaijan, Belarus, Bosnia & ▇▇▇▇▇▇▇▇▇▇▇, ▇▇▇▇▇▇▇, ▇▇▇▇▇▇▇▇▇▇, ▇▇▇▇▇▇▇ ▇▇▇▇▇▇▇▇, ▇▇▇▇▇▇▇▇▇, ▇▇▇▇▇▇▇, ▇▇▇▇▇▇ & Montenegro, Tajikistan, Uzbekistan, Turkey, Iceland, Switzerland and Norway. [**] [**] [**] BioSpecifics Technologies Corp. ▇▇ ▇▇▇▇▇▇ ▇▇▇▇▇▇ Lynbrook, New York 11563 Attention: ▇▇▇▇▇▇ ▇▇▇▇▇▇, President Dear ▇▇▇: In connection with the Amended and Restated Development and License Agreement (the “ License Agreement”) between us, dated as of December , 2008, we wish to confirm to you as follows:

Enzyme. The enzyme is [***]. The Partner Territory consists of the 27 members of the European Union as of the date of this Agreement, specifically Austria, Belgium, Bulgaria, Cyprus, Czech Republic, Denmark, Estonia, Finland, France, Germany, Greece, Hungary, Ireland, Italy, Latvia, Lithuania, Luxembourg, Malta, The Netherlands, Poland, Portugal, Romania, Slovakia, Slovenia, Spain, Sweden and the UK, and Croatia, Albania, Armenia, Azerbaijan, Belarus, Bosnia & ▇▇▇▇▇▇▇▇▇▇▇, ▇▇▇▇▇▇▇, ▇▇▇▇▇▇▇▇▇▇, ▇▇▇▇▇▇▇ ▇▇▇▇▇▇▇▇, ▇▇▇▇▇▇▇▇▇, ▇▇▇▇▇▇▇, ▇▇▇▇▇▇ & Montenegro, Tajikistan, Uzbekistan, Turkey, Iceland, Switzerland and Norway. [**] [**] [**] BioSpecifics Technologies Corp. ▇▇ ▇▇▇▇▇▇ ▇▇▇▇▇▇ Lynbrook, New York 11563 Attention: ▇▇▇▇▇▇ ▇▇▇▇▇▇, President Dear ▇▇▇: In connection with the Amended and Restated Development and License Agreement (the “ " License Agreement”") between us, dated as of December __, 2008, we wish to confirm to you as follows:

Enzyme. The enzyme is [**]. The Partner Territory consists of the 27 members of the European Union as of the date of this Agreement, specifically Austria, Belgium, Bulgaria, Cyprus, Czech Republic, Denmark, Estonia, Finland, France, Germany, Greece, Hungary, Ireland, Italy, Latvia, Lithuania, Luxembourg, Malta, The Netherlands, Poland, Portugal, Romania, Slovakia, Slovenia, Spain, Sweden and the UK, and Croatia, Albania, Armenia, Azerbaijan, Belarus, Bosnia & ▇▇▇▇▇▇▇▇▇▇▇, ▇▇▇▇▇▇▇, ▇▇▇▇▇▇▇▇▇▇, ▇▇▇▇▇▇▇ ▇▇▇▇▇▇▇▇, ▇▇▇▇▇▇▇▇▇, ▇▇▇▇▇▇▇, ▇▇▇▇▇▇ & Montenegro, Tajikistan, Uzbekistan, Turkey, Iceland, Switzerland and Norway. [**] [**] [**] BioSpecifics Technologies Corp. ▇▇ ▇▇▇▇▇▇ ▇▇▇▇▇▇ Lynbrook, New York 11563 Attention: ▇▇▇▇▇▇ ▇▇▇▇▇▇, President Dear ▇▇▇: In connection with the Amended and Restated Development and License Agreement (the “ License Agreement”) between us, dated as of December __, 2008, we wish to confirm to you as follows: