Depression. There is ample evidence from our data for the core validity of the AGECAT depres- sion algorithm, at least with respect to its sensitivity to the relatively severe form of depression implied by our independent- clinician inclusion criterion of a MADRS score of 18 or over. It is possible that applying the diagnostic hierarchy in stage 2 may lead to misclassification of de- pression as dementia. Alternatively, given the typically high rates of dementia inci- dence in cases clinically diagnosed as depressive pseudodementia, ‘false positives’ may reflect an incipient dementia process that was not apparent to the independent LAC, Latin America and the Caribbean.
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Sources: Research Study, Research Study