Common use of Agreements Years 2006 and 2007 Clause in Contracts

Agreements Years 2006 and 2007. For each Quarter during Agreement Years 2006 and 2007, Novartis, after consultation with Reliant, will determine and advise Reliant in writing of the appropriate required PSME amount for the Product, which shall be subject to adjustment pursuant to Article 6.6. It is currently anticipated that the total annual required PSME amount for each such Agreement Year will be [***] dollars ($[***]). Novartis shall reimburse Reliant on a monthly basis for all PSME actually expended by Reliant during Agreement Years 2006 and 2007 which does not exceed in the aggregate the required PSME amount established by Novartis for the applicable period, such reimbursement to be made within ten (10) days following the receipt by Novartis of a monthly non-personal PSME report. [***]: Certain information on this page has been omitted and filed separately with the Commission. Confidential treatment has been requested with respect to the omitted portions.

Agreements Years 2006 and 2007. For each Quarter during Agreement Years 2006 and 2007, Novartis, after consultation with Reliant, will determine and advise Reliant in writing of the appropriate required PSME amount for the Product, which shall be subject to adjustment pursuant to Article 6.6. It is currently anticipated that the total annual required PSME amount for each such Agreement Year will be [***] dollars ($[***]). Novartis shall reimburse Reliant on a monthly basis for all PSME actually expended by Reliant during Agreement Years 2006 and 2007 which does not exceed in the aggregate the required PSME amount established by Novartis for the applicable period, such reimbursement to be made within ten (10) days following the receipt by Novartis of a monthly non-personal PSME report. [***]: Certain information on this page has been omitted and filed separately with the Commission. Confidential treatment has been requested with respect to the omitted portions.

Agreements Years 2006 and 2007. For each Quarter during Agreement Years 2006 and 2007, Novartis, after consultation with Reliant, will determine and advise Reliant in writing of the appropriate required PSME amount for the Product, which shall be subject to adjustment pursuant to Article 6.6. It is currently anticipated that the total annual required PSME amount for each such Agreement Year will be [***] dollars ($[***]). Novartis shall reimburse Reliant on a monthly basis for all PSME actually expended by Reliant during Agreement Years 2006 and 2007 which does not exceed in the aggregate the required PSME amount established by Novartis for the applicable period, such reimbursement to be made within ten (10) days following the receipt by Novartis of a monthly non-personal PSME report. [***]: Certain information on this page has been omitted and filed separately with the Commission. Confidential treatment has been requested with respect to the omitted portions.

Agreements Years 2006 and 2007. For each Quarter during Agreement Years 2006 and 2007, Novartis, after consultation with Reliant, will determine and advise Reliant in writing of the appropriate required PSME amount for the Product, which shall be subject to adjustment pursuant to Article 6.6. It is currently anticipated that the total annual required PSME amount for each such Agreement Year will be [***] twenty five million dollars ($[***]25,000,000). Novartis shall reimburse Reliant on a monthly basis for all PSME actually expended by Reliant during Agreement Years 2006 and 2007 which does not exceed in the aggregate the required PSME amount established by Novartis for the applicable period, such reimbursement to be made within ten (10) days following the receipt by Novartis of a monthly non-personal PSME report. [***]: Certain information on this page has been omitted and filed separately with the Commission. Confidential treatment has been requested with respect to the omitted portions.