Significant Adverse Effect definition

Significant Adverse Effect means any change or effect that, in Parent's judgment, is reasonably likely to adversely affect in a substantial way the benefits and opportunities which Parent reasonably expects to receive from the acquisition of the Retained Business or from Parent's current business. 20

Significant Adverse Effect means (a) for purposes of Section 5.4, the significant possibility, in the reasonable belief of MacroGenics, that the conduct of the applicable Clinical Trial or other clinical study poses (i) a significantly higher risk of either an adverse effect on *** of the applicable *** Program DART or *** Licensed Product, as compared to ***, for such *** Program DART or *** Licensed Product, or (ii) a significant risk of an adverse effect on the ability of MacroGenics or its Affiliates or Sublicensees to recruit patients for active Clinical Trials conducted, or planned Clinical Trials (for which a protocol has been submitted to and not disapproved by Gilead pursuant to Section 5.5, as of the time of submission to MacroGenics pursuant to Section 5.4 of a protocol for the applicable Clinical Trial or study proposed to be conducted by Gilead or its Affiliates or Sublicensees) to be conducted, by MacroGenics or its Affiliates or Sublicensees in the MacroGenics Territory with respect to such *** Program DART or Licensed Product; and (b) for purposes of Section 5.5, the significant possibility, in the *** = Portions of this exhibit have been omitted pursuant to a request for confidential treatment. An unredacted version of this exhibit has been filed separately with the Commission. reasonable belief of Gilead, that the conduct of the applicable Clinical Trial or other clinical study poses (i) a significantly higher risk of either an adverse effect *** Licensed Product, as compared to ***, for such *** Program DART or *** Licensed Product, or (ii) a significant risk of an adverse effect on the ability of Gilead or its Affiliates or Sublicensees to *** ((A) with respect to planned Clinical Trials to be conducted in the Gilead Territory, that are subject to a protocol that has received internal approval by Gilead, and (B) with respect to planned Clinical Trials to be conducted in the MacroGenics Territory, for which a protocol has been submitted to and not disapproved by MacroGenics pursuant to Section 5.4, as of the time of submission to Gilead pursuant to Section 5.5 of a protocol for the applicable Clinical Trial or study proposed to be conducted by MacroGenics or its Affiliates or Sublicensees) to be conducted, by Gilead or its Affiliates or Sublicensees in the Gilead Territory with respect to such *** Program DART or Licensed Product.

Significant Adverse Effect means any action that:

Examples of Significant Adverse Effect in a sentence

• Significant Adverse Effect Any modification alteration, or effect upon a Protected Environmentally Sensitive Area which measurably reduces the Area’s beneficial functions as delineated in the Conservation Element of the City of Mexico Beach Comprehensive Plan.

• The Trustee will on becoming aware of the occurrence of an event having a Significant Adverse Effect on the financial position of a Division give within the Prescribed Period written notice of the event to the Commissioner setting out particulars of the event.

• No Significant Adverse Effect Shall be Caused on Environment While Undertaking Mining Operations: (1) The person undertaking mining operations shall, in undertaking mining operations, have to undertake it without causing significant adverse effect on environment.

• There are substantial differences between the two bills, and significant issues raised by the House bill in particular which, if not resolved satisfactorily, would likely have a Significant Adverse Effect on COMSAT (as defined in the Merger Agreement).

• Based on this analysis, EPA continues to find, as stated at Proposal, that the 316(b) Phase III regulation will not cause a Significant Adverse Effect and does not constitute a Significant Energy Action within the meaning of Executive Order 13211.

More Definitions of Significant Adverse Effect

Significant Adverse Effect means any effect that is material in nature for the Group as a whole and has an adverse effect on the financial conditions, businesses or operations of the Group, regarding the Purchasers’ absolute opinions;

Significant Adverse Effect means a Material Adverse Effect on COMSAT (as hereinafter defined, but including, for purposes of determining whether there has been a Significant Adverse Effect, any effects or changes arising out of, resulting from or relating to general economic, financial or industry conditions) of such seriousness and significance that a reasonable businessperson in similar circumstances would not proceed with the Merger on the terms and conditions set forth in this Agreement. COMSAT will furnish Lockheed Xxxxxx with such certificates and other documents to evidence the fulfillment of the conditions set forth in this Section 3.15(b) as Lockheed Xxxxxx may reasonably request.

Significant Adverse Effect has the meaning set forth in Section 4.1.7.1.

Significant Adverse Effect means a change, situation or event that could reasonably be expected, whether taken individually or in combination with other changes, situations or events, to have a Material adverse effect;

Significant Adverse Effect has the meaning assigned to such term in subsection (f) of Section 4.2.

Significant Adverse Effect means a change, condition or event in operations, projects, businesses, assets, liabilities (actual or contingent) assets, liabilities or condition (financial or otherwise) or results of operations of the Borrower and its Subsidiaries taken as affecting a whole so relevant: (i) the ability by the Borrower to meet its obligations under any Credit Instrument, (ii) the legality, validity, binding effect or enforceability against the Borrower of any Loan Document or (iii) the rights and remedies of the Administrative Agent or the Creditors under the Credit Instruments.

Significant Adverse Effect means an adverse effect on the business, financial condition, operations or performance of the Borrower, the other Loan Parties and the Pledged Subsidiaries, taken as a whole, that results in a loss equal to 10% of Consolidated EBITDA of the Borrower for the most recently completed Measurement Period.