Reference dose definition
Reference dose means a designated toxicity value established in these rules for evaluating potential noncarcinogenic effects in humans resulting from exposure to a chemical(s) of concern. Reference doses are designated in Appendix A.
Reference dose or “RFD” means a benchmark dose, derived from the NOAEL or LOAEL for a hazardous substance by consistent application of uncertainty factors used to estimate acceptable daily intake doses and an additional modifying factor, which is based on professional judgment when considering all available data about a substance, expressed in units of milligrams per kilogram body weight per day. This includes chronic reference doses, subchronic reference doses, and developmental reference doses.
Reference dose or "RfD" means the estimate of the daily intake of a chemical over a lifetime that is not likely to result in any significant adverse health effects (including in sensitive subpopulations).
More Definitions of Reference dose
Reference dose or “RfD” means an estimate of a daily exposure, in units of milligrams of chemical per kilogram of body weight per day (mg/kg/d), to the human population (including sensitive subgroups) that is likely to be without appreciable risk of deleterious effects during a portion of a lifetime (up to approximately seven years, subchronic) or for a lifetime (chronic).
Reference dose means an estimate of a daily exposure level for the human population, including sensitive subpopulations, that is likely to be without an appreciable risk of deleterious effects during a lifetime.
Reference dose means an estimate of a daily exposure to the general human population that is likely to be without an appreciable risk of deleterious effects during a lifetime of exposure.
Reference dose means a toxicity value for evaluating potential non-carcinogenic effects in humans resulting from exposure to a chemical of concern.
Reference dose or "RfD" means a conservative estimate of the daily intake of the human population, including sensitive subgroups, that is likely to be without appreciable risk of deleterious effect during a lifetime. The reference dose is expressed in units of milligrams per kilogram body weight per day.
Reference dose or "RfD" means an estimate of a daily exposure to the human population, including sensitive subpopulations, that is likely to be without appreciable risk or deleterious effects over a lifetime. The RfD is expressed in units of daily dose, mg/kg/day.
Reference dose or "RfD" means an estimate, with uncertainty spanning an order of magnitude, of a daily oral exposure to the human population, including sensitive subgroups, that is likely to be without appreciable risk of deleterious effects during a lifetime. It can be derived from a NOAEL, LOAEL, or BMD, with UFs generally applied to reflect limitations of the data used.