October 11, 2000 DELIVERED PERSONAL & CONFIDENTIAL Mr. Douglas M. Parker 321 Glen Road Toronto, Ontario M4W 2X4 Dear Mr. Parker: Since March 31, 1999 the date you executed your original employment agreement (the "Original Agreement"), Draxis Health...Draxis Health Inc /Cn/ • June 29th, 2001 • Pharmaceutical preparations • Ontario
EXHIBIT 4.8 SUBSCRIPTION AGREEMENT THIS AGREEMENT is made in the City of Montreal, Province of Quebec, as of March 28, 2002; AMONG: SGF SANTE INC., a company duly incorporated pursuant to the laws of Quebec, having its head office at 600 de La...Subscription Agreement • May 20th, 2002 • Draxis Health Inc /Cn/ • Pharmaceutical preparations • Quebec
Exhibit 4.12 UNDERWRITING AGREEMENT April 2, 2004 DRAXIS HEALTH INC. 6870 Goreway Drive Suite 200 Mississauga, Ontario L4V 1P1 ATTENTION: MARTIN BARKIN, PRESIDENT AND CHIEF EXECUTIVE OFFICER Dear Sirs: Desjardins Securities Inc. and CIBC World Markets...Underwriting Agreement • May 14th, 2004 • Draxis Health Inc /Cn/ • Pharmaceutical preparations • Ontario
Exhibit 4.8 SHARE PURCHASE AGREEMENT entered into as of July 16, 2003. BETWEEN : MOHAMMED BARKAT, businessman, residing at 146 MacDonald, Kirkland, Quebec, H9J 3Z3 (the "VENDOR") AND : DRAXIS PHARMA INC., a corporation duly incorporated under the laws...Share Purchase Agreement • May 14th, 2004 • Draxis Health Inc /Cn/ • Pharmaceutical preparations • Quebec
AMONG: DRAXIS HEALTH INC., a corporation incorporated under the laws of Canada, having its head office at 6870 Goreway Drive, Mississauga, Ontario, L4V 1P1, acting and represented herein by Dr. Jim Garner, its Senior Vice President, Finance and Chief...Shareholders' Agreement • May 20th, 2002 • Draxis Health Inc /Cn/ • Pharmaceutical preparations • Quebec
March 28, 2002 Draxis Pharma Inc. 6870 Goreway Drive Mississauga, ON L4V 1P1 Attention: Mr. Jim A.H. Garner Senior Vice President, Finance & CFO Dear Mr. Garner Amendment to Credit Facilities for Draxis Pharma Inc. We refer to the credit agreement...Draxis Health Inc /Cn/ • May 20th, 2002 • Pharmaceutical preparations • Quebec
PERSONAL & CONFIDENTIAL Mr. Danny Brazier 316 Lori Avenue Stouffville, Ontario L4A 6C2 Since July 17, 1998, the date you executed your original employment agreement (the "Original Agreement"), and April 15, 1999 the date you executed your revised...Draxis Health Inc /Cn/ • May 14th, 2004 • Pharmaceutical preparations • Ontario
DRAXIS LETTERHEAD]Master Agreement • June 29th, 2001 • Draxis Health Inc /Cn/ • Pharmaceutical preparations • New York
EXHIBIT 4.14 LOAN AGREEMENT entered into in Montreal as of March 28, 2002. BETWEEN: DRAXIS PHARMA INC., a corporation having an office at 16751 Trans- Canada, Kirkland, Quebec, H9H 4J4 (the "Borrower") AND: Investissement Quebec, a legal person having...Loan Agreement • May 20th, 2002 • Draxis Health Inc /Cn/ • Pharmaceutical preparations • Quebec
PERSONAL & CONFIDENTIAL Mr. Mark Oleksiw 4265 Pinewood, Pierrefonds, Quebec H9H 2W1 Since June 24th, 2002, the date you executed your original employment agreement (the "Original Agreement"), DRAXIS Health Inc. ("DRAXIS" or the "Corporation") has...Draxis Health Inc /Cn/ • May 14th, 2004 • Pharmaceutical preparations • Ontario
PERSONAL & CONFIDENTIAL DELIVERED Roger Mailhot, Ph.D. 59 Byron Street Oakville, Ontario L6J 6E6 Dear Dr. Mailhot: Since August 13, 1990, the date you executed your original employment agreement (the "Original Agreement"), Draxis Health Inc....Draxis Health Inc /Cn/ • June 29th, 2001 • Pharmaceutical preparations • Ontario
Exhibit 4.6 AMENDING AGREEMENT THIS AGREEMENT is made as of March 31, 2003 B E T W E E N: DRAXIS HEALTH INC., a corporation incorporated under the laws of Canada (hereinafter referred to as "Draxis")Amending Agreement • May 14th, 2003 • Draxis Health Inc /Cn/ • Pharmaceutical preparations • Delaware
Second AmendmentSecond Amendment • May 20th, 2002 • Draxis Health Inc /Cn/ • Pharmaceutical preparations
DR. MARTIN BARKIN President and CEO Mississauga Location Tel: (905) 677-0898 #236 Fax: (905) 677-5494 Cellular: (416) 726-8870 mbarkin@draxis.com March 26, 2004 PERSONAL & CONFIDENTIAL Mr. Jerry Ormiston 28 Eagle Road Toronto, Ontario M8Z 4H5 RE:...Draxis Health Inc /Cn/ • May 14th, 2004 • Pharmaceutical preparations
CREDIT AGREEMENTCredit Agreement • June 29th, 2001 • Draxis Health Inc /Cn/ • Pharmaceutical preparations
EXHIBIT 4.28 SHAREHOLDER RIGHTS PLAN AGREEMENT DATED AS OF APRIL 23, 2002Shareholder Rights Plan Agreement • May 20th, 2002 • Draxis Health Inc /Cn/ • Pharmaceutical preparations • Ontario
DRAXIS LOGO]Draxis Health Inc /Cn/ • June 29th, 2001 • Pharmaceutical preparations
Exhibit 4.13 DATED the 22nd day of July, 2003 BETWEEN DRAXIS HEALTH INC. - and - SHIRE BIOCHEM INC. ASSET PURCHASE AGREEMENT Fraser Milner Casgrain LLP 1 First Canadian Place 100 King Street West Toronto, Ontario M5X 1B2 TABLE OF CONTENTSAsset Purchase Agreement • May 14th, 2004 • Draxis Health Inc /Cn/ • Pharmaceutical preparations • Ontario
EXHIBIT 4.4 ASSET PURCHASE AGREEMENTAsset Purchase Agreement • June 29th, 2001 • Draxis Health Inc /Cn/ • Pharmaceutical preparations • Ontario
EXCHANGE AGREEMENTExchange Agreement • October 24th, 1996 • Draxis Health Inc /Cn/ • Pharmaceutical preparations • Missouri
MR. BRIAN M. KING [DRAXIS LOGO] CHAIRMAN OF THE BOARD PRIVATE AND CONFIDENTIAL HAND DELIVERED September 24, 2003 Dr. Martin Barkin 54 Old Forest Hill Road Toronto, ON M5P 2P9 Dear Dr. Barkin: This letter is further to our agreement that Draxis Health...Retirement Compensation Arrangement Trust Agreement • May 14th, 2004 • Draxis Health Inc /Cn/ • Pharmaceutical preparations
January 31, 2008 BY PERSONAL DELIVERY Mr. Mark OleksiwDraxis Health Inc /Cn/ • July 8th, 2008 • Pharmaceutical preparations
Re: Employment AgreementDraxis Health Inc /Cn/ • July 8th, 2008 • Pharmaceutical preparations
Further to the recent Board of Directors, we hereby confirm that your employment agreement with DRAXIS Health Inc. dated October 17, 2003 and amended on March 26, 2004 and January 31, 2008 (the “Employment Agreement”) is hereby amended as follows effective January 1, 2008:
CONFIDENTIAL COPY DISTRIBUTION AGREEMENTDistribution Agreement • March 31st, 2005 • Draxis Health Inc /Cn/ • Pharmaceutical preparations • California
This Distribution Agreement (this “Agreement”) is entered into this 12th day of July, 2000, by and between Draximage, Inc., a Canadian corporation (“Draximage”), and Syncor International Corporation, a Delaware corporation (“Syncor”).
DR. MARTIN BARKIN President and CEO Mississauga Location Tel: (905) 677-0898 #236 Fax: (905) 677-5494 Cellular: (416) 726-8870 mbarkin@draxis.com March 26, 2004 PERSONAL & CONFIDENTIAL Ms. Alida Gualtieri 11026 Paris Street Montreal- Nord, Quebec H2H...Draxis Health Inc /Cn/ • May 14th, 2004 • Pharmaceutical preparations
FIRST AMENDMENT TO DISTRIBUTION AGREEMENTDistribution Agreement • March 31st, 2005 • Draxis Health Inc /Cn/ • Pharmaceutical preparations
This First Amendment to Distribution Agreement is made as of this 6th day of August 2003 by and between Cardinal Health 414, Inc., a Delaware corporation formerly known as Syncor International Corporation (“Cardinal Health”), and Draximage, Inc., a Canadian corporation (“Draximage”), and amends that certain Distribution Agreement, dated July 12, 2000 (the “Agreement”), by and between Cardinal Health and Draximage. Initially capitalized terms used but not defined herein shall have the meanings ascribed thereto in the Agreement.
Re: Employment AgreementDraxis Health Inc /Cn/ • July 8th, 2008 • Pharmaceutical preparations
Further to our recent discussions, we hereby confirm that your employment agreement with DRAXIS Health Inc. dated October 17, 2003 and amended on March 26, 2004 (the “Employment Agreement”) is hereby amended as follows:
DR. MARTIN BARKIN President and CEO Mississauga Location Tel: (905) 677-0898 #236 Fax: (905) 677-5494 Cellular: (416) 726-8870 mbarkin@draxis.com March 26, 2004 PERSONAL & CONFIDENTIAL Mr. John E.M. Durham 102 Mayfair Hudson, Quebec J0P 1H0 RE:...Draxis Health Inc /Cn/ • May 14th, 2004 • Pharmaceutical preparations
Re: Employment AgreementDraxis Health Inc /Cn/ • March 31st, 2006 • Pharmaceutical preparations
By this letter we hereby confirm that in accordance with your nomination as Chief Executive Officer of DRAXIS Health Inc. (“DRAXIS”) effective October 4, 2005, your employment agreement with DRAXIS dated April 27, 2004 as amended as on August 25, 2004 (collectively referred to as the “Agreement”) is amended as follows:
Re: Employment AgreementDraxis Health Inc /Cn/ • March 31st, 2008 • Pharmaceutical preparations
Further to our recent discussions, we hereby confirm that your employment agreement with DRAXIS Health Inc. dated May 15, 2001 and amended March 26, 2004 (the “Employment Agreement”) is hereby amended as follows:
MASTER AGREEMENTManufacturing and Supply Master Agreement • March 31st, 2006 • Draxis Health Inc /Cn/ • Pharmaceutical preparations • Ontario
MANUFACTURING AND SUPPLY MASTER AGREEMENT dated as of January 1, 2005 (“Effective Date”), by PFIZER CANADA INC., a Canadian corporation having its principal office located at 17,300 Trans Canada Highway, Kirkland, Quebec, H9J 2M5 (hereinafter “PFIZER”) and DRAXIS PHARMA, a division of DRAXIS Specialty Pharmaceuticals Inc. (an amalgamation of DRAXIS Pharma Inc. and DRAXIMAGE Inc.), a Canadian corporation having its principal manufacturing facilities at 16751 Trans Canada Highway, Kirkland, Quebec, H9H 4J4 (hereinafter “COMPANY”).
SUPPLY AND DISTRIBUTION AGREEMENTSupply and Distribution Agreement • March 31st, 2005 • Draxis Health Inc /Cn/ • Pharmaceutical preparations • Quebec
a company organized and existing under the laws of the Province of Ontario, having its principal place of business at 16711 Trans-Canada Highway West Kirkland, Quebec H9H 3L1
DRAXIS and Isotope Products Laboratories Sign Distribution AgreementDraxis Health Inc /Cn/ • March 23rd, 2004 • Pharmaceutical preparations
Mississauga, Ontario, March 22, 2004—DRAXIMAGE Inc., the radiopharmaceutical subsidiary of DRAXIS Health Inc. (TSX: DAX, Nasdaq: DRAX), has concluded a distribution agreement with Isotope Products Laboratories (IPL), a California based producer of radioactive sources for Nuclear Medicine and radiography. DRAXIMAGE will market the full line of IPL medical products in Canada, including calibration references for imaging applications plus calibration sources for PET (Positron Emission Tomography) and SPET (Single Photon Emission Tomography), all well-established modes of diagnostic medical imaging. DRAXIMAGE will also introduce the Perflexion™, IPL's new flexible Cobalt-57 flood source, in Canada during the second quarter of 2004.
MANUFACTURE AND SUPPLY AGREEMENT BETWEEN DRAXIS PHARMA, A division of DRAXIS SPECIALTY PHARMACEUTICALS INC. AND JOHNSON & JOHNSON CONSUMER COMPANIES, INC. AS OF SEPTEMBER 4, 2007Manufacturing and Supply Agreement • March 31st, 2008 • Draxis Health Inc /Cn/ • Pharmaceutical preparations
This Manufacturing and Supply Agreement (the “Agreement”), is entered into as of September 4, 2007 (the “Effective Date”), by and between Johnson & Johnson Consumer Companies, Inc., a New Jersey corporation (“Buyer”), and DRAXIS Pharma, a division of DRAXIS Specialty Pharmaceuticals Inc., a Canadian corporation (“Manufacturer”). Buyer and Manufacturer are each a “Party” and are collectively, the “Parties”.
SUPPLY AGREEMENT BETWEEN GLAXOSMITHKLINE INC. (A wholly owned subsidiary of GlaxoSmithKline plc) AND DRAXIS PHARMA, INC. DATED AS OF DECEMBER 18, 2001Supply Agreement • March 31st, 2005 • Draxis Health Inc /Cn/ • Pharmaceutical preparations • Ontario
THIS SUPPLY AGREEMENT (the “Agreement”) is entered in Ontario, Canada on December 18, 2001 (the “Effective Date”) by and between GLAXOSMITHKLINE INC., a corporation organized under the laws of Canada (“GSK”) and DRAXIS PHARMA, INC., a corporation organized under the laws of Canada (“Draxis”). GSK and Draxis are sometimes referred to herein individually as a “Party” and collectively as “Parties.”
