Technical Objectives. [Provide an explanation of the means of achieving the result/product(s).]
Technical Objectives. The following mainframe systems have output processing feeds that need to be captured and processed; Cyberlife with IPS and work flow system (ViewStar), Paris, Vantage, LAB-Income Annuities, RPS, DSS, FMS systems, and Group Systems. Specifications are presented in 9 parts in Section 2 of this Output Processing Services SOW – Output Processing Specifications:
Technical Objectives. Proof of concept preclinical studies and preliminary toxicological studies will be completed during the Phase I efforts. The objective of the proposed Phase II efforts has the overall goal to file an exploratory IND (eIND) for a Phase 0/1 clinical study. Several specific objectives must be met to reach the overall goal to file an eIND. Objective 1: Manufacture and test clinical grade material
Technical Objectives. The technology of deep water scientific cabled observatories is still at its infancy. This situation is contrasted by the fact that deep sea exploration led by the hydrocarbon industry is now mature and industrial products and services are readily available. Taking advantage of the state of the art through cooperation with engineering underwater R&D actors and cooperation with leading companies in this field (e.g. Statoil, Alcatel, Fugro, Tecnomare) and SMEs, ESONET will provide the necessary steps to new cost effective developments and implementation of permanent observation capabilities with high priority for our society. This means that ESONET will facilitate the introduction and adoption of standards in the realm of scientific investigations to enable interoperability on the system and component level. Furthermore the project will enhance capacity building in the context of long term operation of observatory systems. This will result in an improved efficiency regarding scientific cooperation on the European level for instance in shared use of instrument and sensors on different platform-types. The integration of leading European companies and SMEs into the anticipated Network of Excellence will be beneficial to both the industrial and the academic side. The scientific user will be able to adjust the requirement on the observatory system with respect to a technical and economic feasible solution while European companies will be enabled to adapt existing and develop new innovative methods for the prospective ocean observatory system. In this way, ESONET will stay abreast of future changes in the technological field. The offshore oil and gas industry make great use of remotely operated vehicles (work class ROVs). Until recently, only a few scientific institutes in Europe (IFREMER, RCOM, NOCS) had deep water ROVs capable of servicing deep sea observatories. Major investment has now been made or is decided. These partly specialized ROVs or mobile dockers are able to deploy the diverse instrumentation of subsea experiments. SERPENT4, a collaborative project between oil companies, industrial companies and scientific institutions, shows the potential of use of work class ROVs for the deployment of scientific equipment. An objective of ESONET XxX is to provide common procedures based on experience within the offshore industry and standard interfaces to ease the interoperability of these subsea intervention means on the various European observatories.
Technical Objectives. Objectives: [* 1.5 pages omitted] II. DELIVERABLES [*] [*] = CERTAIN CONFIDENTIAL INFORMATION CONTAINED IN THIS DOCUMENT, MARKED BY BRACKETS, HAS BEEN OMITTED AND FILED SEPARATELY WITH THE SECURITIES AND EXCHANGE COMMISSION PURSUANT TO RULE 24B-2 OF THE SECURITIES EXCHANGE ACT OF 1934, AS AMENDED.
Technical Objectives. The three technical objectives of this proposal focus on determining the feasibility for developing a metabolite panel predictive of clinical outcomes in prostate cancer patients treated with radiation therapy (SBRT). In Objective 1, we will use technology in the Waters Center of Excellence at Georgetown University to perform metabolite analysis on de-identified, bio-banked plasma samples from 100 patients. In the first objective, untargeted metabolite profiles will be obtained and analyzed for correlations with clinical outcomes, including cancer recurrence, urinary tract injury and rectal injury. Candidate metabolites will be validated and a metabolite "kit" will be designed and tested in Objective 2. Standard operating procedures (SOPs) will be prepared and purity, stability and storage capacity will be tested. Objective 3 is to consolidate the intellectual property (metabolite panels) within Georgetown University policies and obtain a license to develop and commercialize the biomarker panels. Submitting a final report to NIH staff documenting success in achieving the Phase I milestones will allow preparation of a phase II application to clinically validate the biomarker panel and support commercialization efforts. Contract No. HHSNxxxxxxxx Objective 1. Develop a metabolite biomarker panel of radiation late effects. Task 1.1. Perform untargeted metabolomics profiling of plasma specimens using UPLC-ESI-QTOFMS.
Technical Objectives. The technical objectives of this CRADA project are to develop a new therapeutic entity with activity against gram-negative category A and B biothreat agents. The therapeutic will be a small molecule that can be administered intravenously (i.v.), preferably once- or twice-a-day and will be available for use both as a prophylactic and as a therapeutic against a wide range of biodefense pathogens. These include the gram-negative biodefense pathogens: Escherichia coli, Salmonella (enteritis and Typhi), Shigella dysenteriae, Yersinia pestis, Burkholderia pseudomallei, Campylobacter jejuni and Francisella tularensis, as well as potentially the Category A gram-positive pathogen Bacillus anthracis. This new therapeutic will act through inhibition of bacterial DNA topoisomerase IV and DNA gyrase (ParE and GyrB, respectively). 08IS1120 SOW App. A 3/10 TC02128.0 Trius Therapeutics, Inc.
Technical Objectives. The EaaS solution shall achieve the technical objectives to achieve a high degree of confidentiality, integrity, reliability and availability in accordance with the GSA EaaS BPA.
Technical Objectives. Objective 1: Perform the Phase I and PK clinical trial of IPdR-mediated radiosensitization.
