Gene. A gene is a unit of heredity which is transferred from a parent to child and is thought to determine some feature of the child.
Gene. The description of the gene the gene functional subunit, or the allele mutation contained within the Original Material that makes the Original Material unique. This is specified on page 1 of this Agreement.
Gene. 8.1.1 The related to
Gene. Cell and ERMI have negotiatxx xnd propose to enter into an Agreement and Plan of Reorganization, to which a copy of this Escrow Agreement will be attached as Exhibit B, pursuant to which, ERMI is to receive 0,000,000 common shares of Gene-Cell in exchange for all of the issued and outstanding shares of ERMI.
Gene. Due to similarities in the results between using either part of the pezo-1 gene, it seems that RNAi methods targeting both regions of the pezo-1 gene should allow knockdown of the PEZO-1 expression. The third experimental condition that used a 165 xx xxxx-1 insert into an L4440 background vector showed no penetrance of the nonEmo phenotype indicating that no knockdown RNAi was successful in any of the strains. It was more common to see incomplete penetrance of the nonEmo phenotype within one individual worm, seen as either one gonad arm having oocytes with the nonEmo phenotype (Figure 12, for instance) or in some unique cases with fer-1 strain there appeared to be gonad arms with both nonEmo and Emo oocytes present closest to the vulva (Figures 14, 16-20). Figures 15, 18, 20, and 21 show what RNAi knockdown of the pezo-1 transcript looks like when present in both gonad arms. X. X. Xxxxxxx initially noted that nonEmo oocytes produced by pezo-1 mutant strains still transitioned to the Emo phenotype after being laid onto the growth plate. This process is clearly seen in Figures 15, 17, 18, and 21, where the uterus-located oocytes closest to the vulva are nonEmo and show distinctive fluorescent chromosomes while those laid on the growth plate have undergone endomitotic replication. It seems that the laid oocytes furthest from the vulva show the largest amount of DNA replication, suggesting that the transition between the nonEmo to Emo phenotype is, in part, determined by the time an oocyte is outside the animal. This could be due to changes in the environment of the oocyte as it has now exited the gonadal cavity of the hermaphrodite or it could also be linked with an interaction with the vulva muscles as they are squeezed out of the vulva. When looking at the rrf-3 strain, there were fewer worms that showed RNAi knockdown of the pezo-1 gene and so there were fewer gonads with nonEmo oocytes as compared to the other three strains. This is in contrast to what has been published about this strain, where it has been shown to have higher RNAi sensitivity in the gonad than any other strain and greater than wild type RNAi sensitivity in the germline. I observed a low level of response in my feeding-based RNAi experiments for all of the C. elegans strains I examined; a 10-30% penetrance amongst RNAi replica experiments has also been seen by other labs [77]. In conclusion, RNAi bacterial feeding experiments confirmed that RNAi of pezo-1 protein does cause the nonEmo ph...
Gene. Notwithstanding anything in this Agreement, an employee's scheduled hours of work shall not be construed as guaranteeing the employee minimum or maximum hours of work, An employee who is required to work a minimum of three (3) hours overtime following his scheduled hours of work and where it is not practical for him to enjoy his usual mealtime before commencing such work shall be granted one- half hour with pay in order that he may take a meal break in the Mint cafeteria. Under such conditions he shall be reimbursed his expenses for one
Gene. TRAK agrees to xxxx all Royalty-Bearing Products sold in the United States of America under the license and rights granted by this Agreement with the word "Patent" or "Patents" or the abbreviation "Xxx." and the number of any applicable issued Initial Patent, Research Patent or Post-Research Patent.
Gene. TRAK and PHRI will utilize their best efforts to successfully perform the experiments as described in Paragraph 1 and 4 as soon as possible.
Gene. TRAK shall have the right to terminate this Agreement at any time during the term of this Agreement upon written notice to PHRI, provided that:
