Gene Clause Samples

Gene. The description of the gene the gene functional subunit, or the allele mutation contained within the Original Material that makes the Original Material unique. This is specified on page 1 of this Agreement.

Gene. Due to similarities in the results between using either part of the pezo-1 gene, it seems that RNAi methods targeting both regions of the pezo-1 gene should allow knockdown of the PEZO-1 expression. The third experimental condition that used a 165 ▇▇ ▇▇▇▇-1 insert into an L4440 background vector showed no penetrance of the nonEmo phenotype indicating that no knockdown RNAi was successful in any of the strains. It was more common to see incomplete penetrance of the nonEmo phenotype within one individual worm, seen as either one gonad arm having oocytes with the nonEmo phenotype (Figure 12, for instance) or in some unique cases with fer-1 strain there appeared to be gonad arms with both nonEmo and Emo oocytes present closest to the vulva (Figures 14, 16-20). Figures 15, 18, 20, and 21 show what RNAi knockdown of the pezo-1 transcript looks like when present in both gonad arms. ▇. ▇. ▇▇▇▇▇▇▇ initially noted that nonEmo oocytes produced by pezo-1 mutant strains still transitioned to the Emo phenotype after being laid onto the growth plate. This process is clearly seen in Figures 15, 17, 18, and 21, where the uterus-located oocytes closest to the vulva are nonEmo and show distinctive fluorescent chromosomes while those laid on the growth plate have undergone endomitotic replication. It seems that the laid oocytes furthest from the vulva show the largest amount of DNA replication, suggesting that the transition between the nonEmo to Emo phenotype is, in part, determined by the time an oocyte is outside the animal. This could be due to changes in the environment of the oocyte as it has now exited the gonadal cavity of the hermaphrodite or it could also be linked with an interaction with the vulva muscles as they are squeezed out of the vulva. When looking at the rrf-3 strain, there were fewer worms that showed RNAi knockdown of the pezo-1 gene and so there were fewer gonads with nonEmo oocytes as compared to the other three strains. This is in contrast to what has been published about this strain, where it has been shown to have higher RNAi sensitivity in the gonad than any other strain and greater than wild type RNAi sensitivity in the germline. I observed a low level of response in my feeding-based RNAi experiments for all of the C. elegans strains I examined; a 10-30% penetrance amongst RNAi replica experiments has also been seen by other labs [77]. In conclusion, RNAi bacterial feeding experiments confirmed that RNAi of pezo-1 protein does cause the nonEmo ph...

Gene ral 1.1 The Operator shall take all necessary actions to prevent any unauthorized access to the Channel(s)/Subscribed Channel(s) through the Operator’s Platform.

Gene. The functional unit of inheritance: a specific sequence of nucleotides along the DNA molecule, forming part of a chromosome. Gene expression: The process by which the information in a gene is used to create proteins or polypeptides. Gene families: Groups of closely related genes that make similar products. Gene mutation: A permanent alteration in the DNA sequence that makes up a gene, such that the sequence differs from what is found in most people. Mutations range in size; they can affect anywhere from a single DNA building block (base pair) to a large segment of a chromosome that includes multiple genes. Gene product: The protein or polypeptide coded for by a gene. Genetic engineering: Altering the genetic material of cells or organisms in order to make them capable of making new substances or performing new functions. Genetic polymorphism: a variation in germ-line DNA sequence among individuals, groups, or populations (e.g. a genetic polymorphism might give rise to blue eyes versus brown eyes, or population level differences in metabolic capacity). Genetic polymorphisms may be the result of chance processes or may have been induced by external agents (such as viruses or radiation). Generally, changes in DNA sequence which have been confirmed to be caused by external agents are called “mutations” rather than “polymorphisms”.

Gene. Notwithstanding anything in this Agreement, an employee's scheduled hours of work shall not be construed as guaranteeing the employee minimum or maximum hours of work, An employee who is required to work a minimum of three (3) hours overtime following his scheduled hours of work and where it is not practical for him to enjoy his usual mealtime before commencing such work shall be granted one- half hour with pay in order that he may take a meal break in the Mint cafeteria. Under such conditions he shall be reimbursed his expenses for one

Gene. 1.1 The related to

Gene. TRAK shall have the right to terminate this Agreement at any time during the term of this Agreement upon written notice to PHRI, provided that: (a) In the event GENE-TRAK elects to terminate the Agreement within six (6) months of the Effective Date, GENE-TRAK shall have no further obligation to pay PHRI as provided in Paragraph 5.4 herein and all existing licenses shall terminate immediately. (b) In the event GENE-TRAK elects to terminate the Agreement after six (6) months after the Effective Date, PHRI will wind down and stop the Research Program effective as of one year from the date of such termination. GENE-TRAK will continue to pay for such research pursuant to Paragraph 5.4 on a pro rata basis for work performed by PHRI.

Gene. Terms of this agreement shall be conducted by and interpreted in accordance with the laws of Brunei

Gene. TRAK and PHRI will utilize their best efforts to successfully perform the experiments as described in Paragraph 1 and 4 as soon as possible.