ASA. The studies refered to include long term administration to rats and ferrets and carcinogenicity studies in the mouse and rat. Notwithstanding the above, a programme of toxicological evaluation of balsalazide has been designed to fulfil the present day requirements of the major Regulatory Agencies World Wide. This programme includes re-evaluation of the consequences of repeated administration to rodents and non-rodents, reproduction toxicology and necessary toxicokinetics to enable overall evaluation. To date the initial findings in preliminary studies using high doses of balslazide at large multiples of the proposed dose for man, are substantiating the balsalazide has a low order of toxicity. /s/ Xxxxx Xxxxx Xxxxx X.Xxxxx. Dated: 31st. August, 1992. -------------------------------------------------------------------------------- ADVISOR ON TOXICOLOGY AND SAFETY EVALUATION (R&D Schedule 2 cont ...) COLAZIDE (R) DEVELOPMENT - COMPLETED STUDIES AND ADDITIONAL WORK ---------------------------------------------------------------- ---------------------------------------------------------------------------------------------------------- Glycyx Completed ------------------------ EC Registration Dossier Headings by Biorex Repeat/New Reconstruct ---------------------------------------------------------------------------------------------------------- ----------------------------------- PART IIIA SINGLE DOSE TOXICITY ----------------------------------- - Mouse, oral . - Mouse, ip . - Rat, oral . * - Rat, ip (iv) . * - Mouse, oral: 4-ABA . - Rat, oral: 4-ABA . - Mouse, oral: 5-ASA . - Rat, oral: 5-ASA . - Mouse, oral: 5-ASA/4-ABA . - Rat, oral: 5-ASA/4-ABA . - Mouse, oral: BSZ impurity . - Mouse, ip: BSZ impurity . - Mouse, ip: Colazide . ----------------------------------- PART IIIB - REPEATED DOSE TOXICITY ----------------------------------- Max. Tolerated Dose ------------------- - Dog . Subacute -------- - Rat, 14 days, oral . . * - Mouse, 7 days, oral: BSZ . * - Mouse, 28 day, oral BSZ . * - Rat, 7 days, oral: BSZ . * - Rat, 28 day, oral: BSZ . * - Dog, 28 days, oral . Chronic ------- - Rat, 96 week, oral . . - Ferret, 26 week, oral . . - Dog, 26 week, gavage . - Rat 26 week, gavage . ----------------------------------- PART IIIC Reproduction Studies -----------------------------------
ASA. Subject to PALMSOURCE’s rights under Section 5.3, and any licenses granted herein, all right, title and interest in and to all DELIVERABLES, PORTED PRODUCT, ASA’s CONFIDENTIAL INFORMATION, and works derivative of any of the foregoing, or new releases thereof, including, but not limited to, all INTELLECTUAL PROPERTY RIGHTS therein, shall be the sole and exclusive property of ASA and ACCESS.
ASA. The parties to the ASA agree that the ASA is terminated as of the Effective Date. Administrator shall make available for pickup for a period of sixty (60) days following the Effective Date the property of E11, E11OC, ER12 and/or ER12OC in the possession of Administrator from the offices of Administrator at 0000 X. Xxxxxxx Xxxxxx, Xxxxxxxx Xxxx, Xxxxxxxx 00000 (the “ASA Transition Period”). Each of E11, E11OC, ER12 and ER12OC shall pay over to Administrator all amounts owing under the ASA as of the Effective Date, with such amount due within ten (10) days following Administration providing a final invoice therefor to E11, E11OC, ER12 and ER12OC. In addition, Administrator shall work in good faith with E11, E11OC, ER12 and ER12OC to transition management services to E11, E11OC, ER12 and ER12OC or their respective designees during the ASA Transition Period and shall be compensated therefor at the same rates and under the same terms set forth in the ASA as if the same remained in effect during such time.
ASA. Average Speed of Answer by a live agent (excludes IVR time)
ASA. The studies refered to include long term administration to rats and ferrets and carcinogenicity studies in the mouse and rat. Notwithstanding the above, a programme of toxicological evaluation of balsalazide has been designed to fulfil the present day requirements of the major Regulatory Agencies World Wide. This programme includes re-evaluation of the consequences of repeated administration to rodents and non-rodents, reproduction toxicology and necessary toxicokinetics to enable overall evaluation. To date the initial findings in preliminary studies using high doses of balslazide at large multiples of the proposed dose for man, are substantiating the balsalazide has a low order of toxicity. /s/ Xxxxx X. Xxxxx ------------------ Xxxxx X. Xxxxx. Dated: 31st, August, 1992. -------------------------------------------------------------------------------- Adviser on Toxicology and Safety Evaluation COLAZIDE(R) DEVELOPMENT - Completed Studies and Additional Work --------------------------------------------------------------- -------------------------------------------------------------------------------- EC Registration Dossier Headings Completed Glycyx by Biorex Repeat/New Reconstruct --------------------------------------------------------------------------------
ASA. The Gas Turbine and Hydroelectric Generating Stations Sales Agreement dated as of November 24, 1998 by and between NY-Gen LLC and O&R.
ASA. Average Speed of Answer. Average time to answer all calls --- handled to the queue.
ASA. 2.3 The ASA is the UK’s independent regulator for ensuring that advertising in all media is legal, decent, honest and truthful, for the benefit of people, society and advertisers.
ASA. 2.1 If ASA is ******* for any month, the applicable monthly invoice payable by Company will include a ******* discount on the Basic Monthly Usage Fees or Actual Agent Call Minute price(s) set forth in Section 10.2 and/or 10.3 of the Amendment, as applicable.
ASA. Execution The Authorised Persons to this ASA shall attend and participate fully in meetings of the several relevant committees/groups set up by the Ministry 3.2 Reviews The Authorised Persons of this ASA shall exchange progress reports on a quarterly basis. The Quarterly Reports submitted by the RHA shall provide such information as may be required by the Ministry to meet its duties to monitor the activities of the RHA. The Ministry will develop and agree on formats for such reports with the RHAs. In addition, the Ministry and the RHA shall jointly review progress with implementation of this ASA on a quarterly basis in 2010/11, the two authorised representatives named on this ASA to be present. 3.3 Variations to this Annual Services Agreement Variations to this ASA may only be made by agreement between the Authorised Persons in writing and in numbered sequence 3.4 Best Endeavours In the event of disagreement, both parties have a duty of care to resolve matters without resorting to arbitration arrangements. In particular, the Authorised Annual Services Agreement 2010/11 Ministry of Health and the North West Regional Health Authority _____________________________________________________________________
