Prodrug definition

Prodrug means a chemical precursor of PRODUCT which is to be cleaved in a human being directly into PRODUCT and/or a metabolic intermediate thereof, but excluding for greater certainty, antigen processing;

Prodrug means different pharmaceutical compounds which, following administration, are converted into structurally similar active metabolites.

Prodrug means any compounds which, following administration, are actively converted in the body to Compound A or Compound B.

Examples of Prodrug in a sentence

• Prodrug design: Basic concept, Carrier linked prodrugs/ Bioprecursors, Prodrugs of functional group, Prodrugs to improve patient acceptability, Drug solubility, Drug absorption and distribution, site specific drug delivery and sustained drug action.

• The subject emphasis on modern techniques of rational drug design like quantitative structure activity relationship (QSAR), Prodrug concept, combinatorial chemistry and Computer aided drug design (CADD).

• Huttunen, Secondary Carbamate Linker Can Facilitate the Sustained Release of Dopamine from Brain-Targeted Prodrug.

• Increasing Oral Absorption of Polar Neuraminidase Inhibitors: A Prodrug Transporter Approach Applied to Oseltamivir Analogue, Mol Pharm.

• L., Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1- f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses.

More Definitions of Prodrug

Prodrug means, with respect to a compound, a composition of matter that is designed to have such compound as its only primary Major Metabolite.

Prodrug means a compound which is designed to be converted, subsequent to administration to a patient, by metabolic processes to a different compound having anti-infective pharmacological activity.

Prodrug. The term “

Prodrug means a compound that is initially administered to the body in an inactive (or less than fully active) form, and then becomes converted to its active form through the normal metabolic processes of the body and non-metabolic processes such as pH or hydrolysis driven cleavage processes and intrinsic cleavage based on an internal cyclization-cleavage mechanism.

Prodrug means a pharmaceutical compound which, following administration to a human, is metabolized into the Compound or an Improvement.

Prodrug means any chemical entity that upon or after administration to a human is transformed into a Compound, wherein said Compound and/or its metabolites are substantially the only pharmaceutically active metabolic products.

Prodrug means a compound that may or may not be pharmacologically active that undergoes an in vivo metabolism producing a second compound exhibiting a pharmacological effect. By way of example only, arbaclofen placarbil is a Prodrug of R-baclofen, i.e., arbaclofen placarbil is metabolized in vivo to form R-baclofen.