Lead Antibody definition

Lead Antibody means (i) any RON Antibody that has been identified by AVEO prior to the Effective Date; (ii) any RON Antibody that is a derivative of any of the Antibodies described in clause (i) identified or generated by either Party during the first [**] months of the Research Term; (iii) any RON Antibody that is a derivative of any of the Antibodies described in clauses (i) or (ii) identified or generated anytime after the first [**] months of the Research Term but excluding any such derivative Antibody under this clause (iii) that [**] described in clause (i) or (ii) above; and (iv) in each case under clauses (i),

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Lead Antibody means the [*****]

Lead Antibody means a Program Antibody that meets the Lead Selection Criteria as determined by the Joint Research Committee.

Examples of Lead Antibody in a sentence

• The Joint Research Committee shall update and amend, as appropriate, the then current Schedule 2.14 as necessary during each Contract Year and on the expiration of the Research Program Term in order to list all Antibody Targets, Program Targets, Program Targets with Program Antibodies, Program Targets with Lead Antibody and Program Targets with Lead Antibody in Development at that point in time.

• On a Lead Antibody, EDC Antibody, Licensed Antibody and Licensed TAP Antibody basis, ImmunoGen hereby grants to Aventis and its Affiliates, subject to Section 7.1.8 below, an exclusive (even as to ImmunoGen and its Affiliates), worldwide, royalty-free license, with the right to grant sublicenses to Approved Subcontractors, under ImmunoGen Intellectual Property, to Develop Products.

• If the Joint Research Committee accepts any such proposal, then, subject to Section 2.8.3 (in the event that a Lead Antibody has been Developed against such Program Target), such Antibody Target or Program Target shall thereafter be deemed to be a “Dropped Target”.

• The transfer of Licensed Lead Antibody Compound drug substance inventory and consumables within the Licensed Materials constitutes a transfer of all right, title and interest in and to such materials, provided that ▇▇▇▇▇ may use such materials solely to Exploit Licensed Products in accordance with this Agreement.

• Neither Party shall publish the sequence of the Licensed Lead Antibody Compound or information concerning the manufacture of the Licensed Lead Antibody Compound without the prior written consent of the other Party.

More Definitions of Lead Antibody

Lead Antibody means (i) any ▇▇▇ Antibody that has been identified by AVEO prior to the Effective Date; (ii) any ▇▇▇ Antibody that is a derivative of any of the Antibodies described in clause (i) identified or generated by either Party during the first [**] months of the Research Term; (iii) any ▇▇▇ Antibody that is a derivative of any of the Antibodies described in clauses (i) or (ii) identified or generated anytime after the first [**] months of the Research Term but excluding any such derivative Antibody under this clause (iii) that [**] described in clause (i) or (ii) above; and (iv) in each case under clauses (i), (ii) and (iii), any binding fragment of such ▇▇▇ Antibody and any such ▇▇▇ Antibody or binding fragment conjugated or fused to any other polypeptide.

Lead Antibody means the VAP-1 Antibody selected by BioTie (BTT-1023, known to Medarex as MDX-1352) to become the subject of an Exclusive Commercial License and whose Binding Sequence is set forth in Exhibit B. A Backup Antibody may be substituted for a Lead Antibody pursuant to Section 2.1.2.

Lead Antibody shall have the meaning set forth in the Recitals. ​

Lead Antibody means MDX-010, which has the amino acid sequences for CDR 1, 2 and 3 of the heavy chain variable region as Previously Disclosed.

Lead Antibody means the humanized anti-human PD-1 monoclonal antibody SHR-1210, as exemplified by the sequence in Exhibit A. [**] = Portions of this exhibit have been omitted pursuant to a confidential treatment request. An unredacted version of this exhibit has been filed separately with the Commission.

Lead Antibody means (i) any ▇▇▇ Antibody that has been identified by AVEO prior to the Effective Date; (ii) any ▇▇▇ Antibody that is a derivative of any of the Antibodies described in clause (i) identified or generated by either Party during the first [**] months of the Research Term;

Lead Antibody means the humanized anti-human PD-1 monoclonal antibody SHR- 1210, as exemplified by the sequence in Exhibit A.