EC50 definition

EC50 means the median effective concentration and is a statistically or graphically estimated concentration that is expected to cause one or more specified effects in fifty per cent of a group of organisms under specified conditions.

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EC50 means the point estimate of the concentration of a toxic substance, wastewater effluent or other aqueous mixture which causes an adverse effect including mortality to 50% of the exposed organisms in a given time period, when compared to an appropriate control.

EC50 means a statistically or graphically estimated concentration that is expected to cause 1 or more specified effects in 50% of a group of organisms under specified conditions.

Examples of EC50 in a sentence

• EC50 value is calculated with four parameter logistic equation: Y=Bottom + (Top-Bottom)/(1+10^((LogEC50-X)*HillSlope)) X is the logarithm of concentration.

• EC50 value is calculated with four parameter logistic equation: Y=Bottom + (Top-Bottom)/ (1+10^ ((LogEC50-X)*HillSlope)) X is the logarithm of concentration.

• The EC50 value (i.e., the molar concentration of insulin that produces 50% of the maximum possible response that insulin is capable of) for suppression of lipolysis by insulin is between 7 and 16 µU/mL76,88-92, whereas the EC values G G G G I G I G I G G I G I G I Figure 2.

• A 48-step optimization process significantly improved the potency (EC50 to 20 nM) and the pharmacokinetic properties of the drug (Hadida et al., 2014).

• While displaying unimpressive potency (EC50 ≈ 2 µM), this lead was attractive because it showed higher in vitro efficacy than a benchmark investigational CFTR potentiator (genistein), and it was able to potentiate both G551D- and temperature- corrected F508del-CFTR currents from human bronchial epithelial cells (Hadida et al., 2014).

More Definitions of EC50

EC50 means a concentration of a toxic substance which causes an adverse effect including mortality in 50% of the exposed organisms in a given time period.

EC50 shall have the meaning set forth in Exhibit A.

EC50 means the concentration of a test substance which results in a 50% response to the effect measured by the test (e.g. reduction in either growth or growth rate relative to the control) within a defined period of exposure;

EC50 means, for Acute Toxicity Testing, the statistical estimate of the toxicant concentration that has a specified adverse effect (such as immobilization, change in respiration rate, or loss of equilibrium) on 50 percent of test organisms after a specific time of exposure.

EC50 means the point estimate of the toxicant concentration that would cause an observable adverse effect (e.g., death, immobilization or serious incapacitation) in 50% of the test organisms.

EC50 means the concentration of effluent that would cause an observable adverse effect (e.g., death, immobilization or serious incapacitation) in 50% of the test organisms.

EC50 means median effective concentration or the concentration of a substance required to produce a response in 50% of the test organisms;