Development Candidate Criteria definition
Development Candidate Criteria means the criteria set forth in Schedule 1.14 hereto which shall be applicable to any Compound selected by Vertex as a Development Candidate hereunder.
Development Candidate Criteria means the criteria set forth in the applicable Research Plan for a Licensed Compound to achieve development candidate status as determined by the JRC in accordance with Section 2.5.
Development Candidate Criteria means, on a Selected Target-by-Selected Target basis, those specific development candidate criteria set out in the relevant Research Plan, which in each case shall be consistent with the criteria set out in the general form of Research Plan attached hereto as Schedule 1.116.
Examples of Development Candidate Criteria in a sentence
For clarity, ▇▇▇▇▇▇’s Final Report for WP3 shall be comprised of [***] relevant for the JSC to evaluate and confirm whether the Development Candidate Criteria have been achieved.
In determining which Lead Generation Candidates should be nominated as Development Candidates, the JSC may consider partial fulfillment of certain Development Candidate Criteria as being sufficient, provided that substantial progress has been made.
Within [***], the JSC will evaluate Lead Generation Candidates recommended by the Parties using the applicable Development Candidate Criteria to determine which Lead Generation Candidate meet such criteria and should be nominated as Development Candidates.
More Definitions of Development Candidate Criteria
Development Candidate Criteria means the criteria the JSC uses to determine whether an SRA Drug Candidate is an SRA Development Candidate and/or whether a New Compound is a New Compound Development Candidate. The Development Candidate Criteria as of the Effective Date are attached hereto as Appendix 1.18.
Development Candidate Criteria means key data regarding the developability characteristics of a Collaboration Compound candidate for nomination as a Development Candidate for IND enabling studies. Typically the developability criteria will include data regarding [***] of the Collaboration Compound and other pharmacokinetic parameters of the Collaboration Compound in [***] as well as a preliminary assessment of the risk of [***], as well as evaluation of [***]. An assessment of toxicokinetics and selection of GLP toxicity species should be typically included with preliminary repeat dose toxicity in [***], genotoxicity (▇▇▇▇ test), and cardiac (hERG) safety. In addition, the properties of the Collaboration Compound regarding purity, solution and solid state stability and physicochemical properties should be included. Assessment of the consistency of the chemical form, scalability of synthetic routes and availability of starting materials will also be typically included in the assessment.
Development Candidate Criteria means, collectively, with respect to each New Target, the criteria that will inform [***] whether a lead Arcus Molecule in the applicable New Target Program will be [***], which criteria are set forth in the New Target R&D Plan for the New Target Program for such New Target. As of the Amendment No. 2 Execution Date, the Development Candidate Criteria for each of the Initial New Targets are as set forth on Exhibit A to this Amendment No. 2.
Development Candidate Criteria means the criteria set forth in WP3 of the Research Plan, as may be amended from time to time by the JSC in accordance with Section 2.1(c).
Development Candidate Criteria are the criteria set out in Schedule 1.15, and as such criteria may be subsequently revised by the JRC.
Development Candidate Criteria means the criteria set out in Schedule 1.15, as such criteria may subsequently be revised by the Parties as an amendment to this Agreement.
Development Candidate Criteria means, with respect to a Collaboration Target, (a) the criteria for Degraders directed to such Collaboration Target set forth in the Candidate Development Plan as “Development Candidate Criteria” for such Collaboration Target, which criteria are intended to indicate that such Degraders are suitable for testing in IND-Enabling Studies, and (b) the IP Criteria for Degraders directed to such Collaboration Target (to the extent not set forth in the Candidate Development Plan).