Candidate Compound definition

Candidate Compound means: (a) any compound that has activity, with respect to the target protein expressed by the applicable Accepted Cell Line, which activity is initially discovered or detected by using an Accepted Cell Line or materials or assays derived from an Accepted Cell Line, where such activity is potentially useful for therapeutic or prophylactic use, or (b) any compound that is an analog, homolog, isomer or other chemical derivative of a compound that meets the criteria in subsection (a) above (the “Parent Compound”), provided that such compound (i) was made by or on behalf of BMS or its Affiliate or sublicensee based on information relating to the Parent Compound, and (ii) has activity that is potentially useful for therapeutic or prophylactic use and is similar or related to the activity of such Parent Compound (with the understanding that such activity may be superior to the activity of the Parent Compound, in any appropriate criteria).

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Candidate Compound means a Lead Compound which the JRC has proposed to Abbott for clinical development in humans, or a salt, ester, amide, complex, chelate, hydrate, stereoisomer, crystalline or amorphous form, prodrug, metabolite, or metabolic precursor of such Lead Compound.

Candidate Compound means a Compound selected by the Joint Steering Committee under this Agreement, for study in Screening Activities and, if applicable, in a Feasibility Study, directed toward development of a Product.

Examples of Candidate Compound in a sentence

BMS shall promptly notify Athersys of the first occurrence of any milestone with respect to each Candidate Compound.
If BMS develops as a back-up Candidate Compound that inhibits or otherwise modulates the activity of a particular molecular target of a Candidate Compound on which BMS is already making milestone payments, then BMS may conduct clinical development on such back-up or follow-on Candidate Compounds and shall not be obligated to make any milestone payments with respect to any such back-up or follow-on Candidate Compound, except as otherwise provided below.
Milestone payments shall be made only once with respect to any given Candidate Compound, regardless of the number of indications sought (or approvals obtained) with respect to such Candidate Compound, whether alone or in combination with other compounds or products, and regardless of any new dosage strengths, preparations or forms of administration for such Candidate Compound.
For each Accepted Cell Line used in the Field, BMS shall pay Athersys the milestone payments set forth in Exhibit B within thirty (30) days after each milestone event has been achieved for each Candidate Compound identified for clinical development by BMS or its Affiliate or sublicensee for the particular Accepted Cell Line.
In addition, for each Candidate Compound as to which Sanofi has exercised its Development and Commercialization Option under the preceding sentence, Sanofi will be entitled to designate two Back-up Compounds to such Candidate Compound to include as Licensed Compounds, such designation to be made by written notice given to Rib-X at any time during the Research Term or Follow-on Period.

More Definitions of Candidate Compound

Candidate Compound means any Target Compound that is nominated as a Candidate Compound under Section 2.7.

Candidate Compound means a Recommended Compound which has been selected by the appropriate research and development committee of Sankyo under Section 4.3 hereof for further development and evaluation under this Agreement.

Candidate Compound means an Aptamer that is a Short Acting Coagulation Cascade Aptamer that is identified by Archemix in the course of its Research under this Agreement pursuant to an approved Research Plan.

Candidate Compound means, at any point in time, any Pfizer Compound identified as a Candidate Compound at that time in the Design/Preclinical Collaboration Plan, as provided in Section 2.2, and any salt, stereoisomer, enantiomer, diastereomer, tautomer, racemate, free acid form or free base form of any such compound, including any hydrate, solvate, polymorph or other physical form of such compound.

Candidate Compound means any Test Compound or Derivative ------------------ Compound which has demonstrated activity in the Primary Field in Initial Screening. **Certain portions of this Exhibit have been omitted based upon a request for confidential treatment that has been filed with the Commission. The omitted portions have been filed separately with the Commission.

Candidate Compound means a Lead Molecule or a compound ------------------ synthesized, identified or produced on the basis of a Lead Molecule that, in the reasonable determination of the Steering Committee pursuant to Section 2.4 (i), a) exhibits an in vitro activity and profile acceptable for Development, b) exhibits an in vivo activity and profile in a relevant animal model of disease acceptable for Development, c) is potentially patentable or otherwise ___________________ * This portion of the Exhibit has been omitted pursuant to a Request for Confidential Treatment under Rule 406 of the Securities Act of 1933, as amended. The complete Exhibit, including the portions for which confidential treatment has been requested, has been filed separately with the Securities and Exchange Commission. p.1 protectable and does not infringe the intellectual property rights of third parties, d) is one for which a plausible manufacturing strategy can be devised, and e) exhibits an acceptable therapeutic ratio in a 14-day toxicity model compared to the efficacy dose required in an animal model of disease.

Candidate Compound means, (a) with respect to the [***] Research Program, any Degrader that is [***] or (b) with respect to an Immunology Research Program, any Degrader that is: [***]. Notwithstanding the foregoing, all Candidate Compounds under a given Immunology Research Program will cease being Candidate Compounds following the License Effective Date for such Immunology Research Program whereupon they will become Licensed Compounds for the purposes of this Agreement. [***]