Toxicity. No additional information available *** Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions. 1/22/2014 EN (English) 7/9 *** Certain information in this document has been omitted and filed separately with the Securities and Exchange Commission. Confidential treatment has been requested with respect to the omitted portions. Silica Sand Safety Data Sheet
Toxicity. Ecology - general : Hydrogen peroxide is naturally produced by sunlight (between 0.1 and 4 ppb in air and 0.00 to 0.1 mg/L in water). Not expected to have significant environmental effects. Hydrogen peroxide (7722-84-1) LC50 fish 1 16.4 mg/l (Exposure time: 96 h - Species: Pimephales promelas) EC50 Daphnia 1 18 – 32 mg/l (Exposure time: 48 h - Species: Daphnia magna [Static]) LC50 fish 2 18 – 56 mg/l (Exposure time: 96 h - Species: Lepomis macrochirus [static])
Toxicity. Based on the available ecotoxicity and mammalian data, Dechlorane Plus does not currently meet the T criterion. Long-term toxicity studies using relevant life stages of fish (via diet), sediment or soil organisms, and/or birds could be performed to clarify whether adverse effects can occur via these exposure routes. However, as the substance meets both the vP and vB criteria, these are not scientifically necessary for environmental risk management purposes.
Toxicity the liver, spleen, kidney, and heart will be examined by histology for necrosis or immune cell infiltrates. Above plan is to assess the effect of dexamethasone treatment on disease progression beginning from the onset phase. If needed, a similar plan will be followed for another group of mice in which efficacy of drug delivery to suppress a relapse flare will be tested. For TGFβ2, a similar plan will be followed as described above for dexamethasone.