Lead Compounds definition

Lead Compounds means a compound (or compounds) which

Lead Compounds means not more than two Compounds from each Program — Primary or Alternate - for which a Testing Request is delivered, none of which are a Development Candidate, which meet the following criteria: (i) the Compound(s) have been selected by Vertex from the Primary Program and/or the Alternate Program, as relevant to the Testing Request (assuming CFFT has not terminated the Alternate Program under the provisions of Section 10.5.3 hereof); (ii) each Compound will be representative of those Compounds in each Program which Vertex believes to be the most promising as potential Drug Products; and (iii) each Compound shall have been previously tested by Vertex, in vitro, as to potential efficacy and potency in CF, and the results of that testing shall have been provided to CFFT. Vertex and CFFT acknowledge that commercially available assays for the testing of Lead Compounds may yield results which are less robust than the results obtained by Vertex in its own proprietary assays. The parties also acknowledge that the transfer of Vertex’s proprietary assays to an Agreed Lab may be difficult, and the results less than satisfactory, without a commitment of substantial time and effort by Vertex which, if undertaken, may adversely impact the progress of the Research Program. Therefore, the parties agree that Vertex’s responsibility for the testing provided under this Section 2.10 shall be limited as follows: (a) Vertex will cooperate with CFFT in the selection of an Agreed Lab as soon as practicable following the Effective Date, as may be requested by CFFT, and thereafter will assist in the determination whether commercially available assays conducted by the Lab are likely to provide satisfactory results; (b) Vertex will Information redacted pursuant to a confidential treatment request. An unredacted version of this exhibit has been separately filed with the Commission. provide the Lab with requisite amounts of each Lead Compound, in connection with formal Testing Requests from CFFT as provided above, and up to three additional Compounds from each of the Primary or Alternate Programs, out of any supplies which Vertex may have on hand, the chemical structures of which have been published by Vertex in peer-reviewed journals or through posters or presentations at scientific conferences, which the Agreed Lab may use for control purposes; (c) Vertex will provide telephone consulting to appropriate representatives of the Agreed Lab concerning applicable assay methodology; (d) ...

Lead Compounds means any organic or inorganic derivatives of lead.

Examples of Lead Compounds in a sentence

• The RMC will select the Collaboration Lead Compounds by a unanimous vote pursuant to Section 3(b).

• The Parties agree to use commercially reasonable efforts to develop Collaboration Lead Compounds for use in the Field, making use of each Party's special expertise as directed by the RMC with the intent of obtaining all worldwide approvals or authorizations necessary for the manufacture, distribution, use or sale of a Product in the Territory ("Regulatory Approval") and bringing Products to the market as soon as reasonably practicable thereafter.

• The Parties recognize that the prompt allocation of appropriate medicinal chemistry resources to optimize Lead Compounds will confer a competitive advantage upon the Research Program.

• Tularik will then be free to pursue clinical development and registration of such compounds, Lead Compounds and/or Products without obligation to JT except as provided in Section 4(f) or Section 5(c), as appropriate.

• At CFFT’s written request (a “Testing Request”) delivered as provided below, Vertex will supply to an “Agreed Lab” reasonably adequate quantities of its “Lead Compounds” as necessary to enable the Agreed Lab to conduct in vitro testing of the efficacy and potency of the Lead Compounds in agreed CF assay models.

More Definitions of Lead Compounds

Lead Compounds means not more than two Compounds from each Program — Primary or Alternate - for which a Testing Request is delivered, none of which are a Development Candidate, which meet the following criteria: (i) the Compound(s) have been selected by Vertex from the Primary Program and/or the Alternate Program, as relevant to the Testing Request (assuming CFFT has not terminated the Alternate Program under the provisions of Section 10.5.3 hereof); (ii) each Compound will be representative of those Compounds in each Program which Vertex believes to be the most promising as potential Drug Products; and

Lead Compounds means those compounds which have [Text Omitted] as determined and selected by NEWCO from the NCEs.

Lead Compounds means each of the proprietary compounds of the Company known as NXT-3683 and NXT-5834, compounds specifically claimed in any Patent Rights within the Company Registrations as of the Closing Date, in each case as listed on Schedule 2.8(h)(v), or any salts, esters, polymorphs, isomers or metabolites thereof, in any form or formulation.

Lead Compounds means those Compounds (i) [***], (ii) that meet the criteria set forth on Exhibit B hereto and (iii) that are selected by the Steering Committee or Wyeth-Ayerst in accordance with Article Six, provided, however, that Lead Compounds shall specifically exclude any Compounds [***]. Notwithstanding the foregoing, for purposes of calculating Net Sales and determining License Fees and Royalty payments under this Agreement, a Lead Compound together with all complexes, mixtures and other combinations, prodrugs, metabolites, enantiomers, salt forms, racemates, isomers, and derivatives thereof, shall be considered to be a single Lead Compound.

Lead Compounds has the meaning set forth in Section 1.14.1.

Lead Compounds means those Selected Compounds which are designated by SPL as Lead Compounds (pursuant to Section 2.2(b) of the Agreement) for the performance of medicinal chemistry optimization by NeoGenesis.

Lead Compounds means those certain compounds identified as BCX 1812, 1827, 1898 and 1923.