Significant Adverse Effect means any change or effect that, in Parent's judgment, is reasonably likely to adversely affect in a substantial way the benefits and opportunities which Parent reasonably expects to receive from the acquisition of the Retained Business or from Parent's current business. 20
Significant Adverse Effect means (a) for purposes of Section 5.4, the significant possibility, in the reasonable belief of MacroGenics, that the conduct of the applicable Clinical Trial or other clinical study poses (i) a significantly higher risk of either an adverse effect on *** of the applicable *** Program DART or *** Licensed Product, as compared to ***, for such *** Program DART or *** Licensed Product, or (ii) a significant risk of an adverse effect on the ability of MacroGenics or its Affiliates or Sublicensees to recruit patients for active Clinical Trials conducted, or planned Clinical Trials (for which a protocol has been submitted to and not disapproved by Gilead pursuant to Section 5.5, as of the time of submission to MacroGenics pursuant to Section 5.4 of a protocol for the applicable Clinical Trial or study proposed to be conducted by Gilead or its Affiliates or Sublicensees) to be conducted, by MacroGenics or its Affiliates or Sublicensees in the MacroGenics Territory with respect to such *** Program DART or Licensed Product; and (b) for purposes of Section 5.5, the significant possibility, in the *** = Portions of this exhibit have been omitted pursuant to a request for confidential treatment. An unredacted version of this exhibit has been filed separately with the Commission. reasonable belief of Gilead, that the conduct of the applicable Clinical Trial or other clinical study poses (i) a significantly higher risk of either an adverse effect *** Licensed Product, as compared to ***, for such *** Program DART or *** Licensed Product, or (ii) a significant risk of an adverse effect on the ability of Gilead or its Affiliates or Sublicensees to *** ((A) with respect to planned Clinical Trials to be conducted in the Gilead Territory, that are subject to a protocol that has received internal approval by Gilead, and (B) with respect to planned Clinical Trials to be conducted in the MacroGenics Territory, for which a protocol has been submitted to and not disapproved by MacroGenics pursuant to Section 5.4, as of the time of submission to Gilead pursuant to Section 5.5 of a protocol for the applicable Clinical Trial or study proposed to be conducted by MacroGenics or its Affiliates or Sublicensees) to be conducted, by Gilead or its Affiliates or Sublicensees in the Gilead Territory with respect to such *** Program DART or Licensed Product.
Significant Adverse Effect means any action that:
Examples of Significant Adverse Effect in a sentence
Significant Adverse Effect Any modification alteration, or effect upon a Protected Environmentally Sensitive Area which measurably reduces the Area’s beneficial functions as delineated in the Conservation Element of the City of Mexico Beach Comprehensive Plan.
The Trustee will on becoming aware of the occurrence of an event having a Significant Adverse Effect on the financial position of a Division give within the Prescribed Period written notice of the event to the Commissioner setting out particulars of the event.
No Significant Adverse Effect Shall be Caused on Environment While Undertaking Mining Operations: (1) The person undertaking mining operations shall, in undertaking mining operations, have to undertake it without causing significant adverse effect on environment.
There are substantial differences between the two bills, and significant issues raised by the House bill in particular which, if not resolved satisfactorily, would likely have a Significant Adverse Effect on COMSAT (as defined in the Merger Agreement).
The Project’s Anticipated 90% Reduction in Employment Levels is a Significant Adverse Effect Provincial standards on employment land use and densities Provincial policy demands that economic development fit together with residential communities and protection of natural heritage systems.
More Definitions of Significant Adverse Effect
Significant Adverse Effect means any effect that is material in nature for the Group as a whole and has an adverse effect on the financial conditions, businesses or operations of the Group, regarding the Purchasers’ absolute opinions;
Significant Adverse Effect has the meaning set forth in Section 4.1.7.1.
Significant Adverse Effect means an adverse effect on the business, financial condition, operations or performance of the Borrower, the other Loan Parties and the Pledged Subsidiaries, taken as a whole, that results in a loss equal to 10% of Consolidated EBITDA of the Borrower for the most recently completed Measurement Period.
Significant Adverse Effect means any significant adverse effect on the financial condition or on the operating results of the Companies resulting in Losses of an amount equal to or greater than USD 10,000,000 (ten million dollars 00/100 legal tender of the United States of America), on the understanding, however, that any adverse effect that is a consequence of or results from, or is attributable to, (a) any event or circumstance or series of events or circumstances affecting (i) the economy, capital markets, financial, banking, credit or securities markets in general, including changes in interest rates or exchange rates in Mexico, the United States of America or any other country or region, (ii) political, health or social conditions (including any situation or condition related to the COVID-19 pandemic) in Mexico, the United States of America or any other country or region, or (iii) generally, the industry in which the Companies operate or provide services, (b) the negotiation, dispute, announcement or completion of the transactions considered in this Contract, compliance with the obligations considered in this Contract, including adverse effects related to the fulfillment of obligations or agreements contained in this Contract, failure to take any action as a result of any restrictions or prohibitions contained in this Contract and any immediate adverse effects caused by the deficit or decrease in income, margins or performance, (c) any changes in the Applicable Law, in the Accounting Standards, or in the accounting principles, practices or policies that the Buyers, any of the Sellers or the Companies are obliged to adopt, or compliance with or interpretation thereof, (d) actions or omissions specifically permitted under this Agreement, or actions or omissions permitted upon request of, or with the consent of the Buyers, (e) the effect of any action of the Buyers or their Affiliates with respect to any of the transactions considered in this Contract or any Seller, the Companies or their respective Affiliates, (f) any acts of God or force majeure events including earthquakes, hurricanes, tornadoes, floods, tsunamis, or any other natural disaster, or any damage or destruction of assets caused accidentally, (g) any hostility, acts of war (whether or not declared) sabotage, terrorism or military actions, (h) failure to comply with any projections, estimates or forecasts as to revenues, earnings, or any other measurement of financial performance or transactions, whether internal or p...
Significant Adverse Effect means a change, condition or event in operations, projects, businesses, assets, liabilities (actual or contingent) assets, liabilities or condition (financial or otherwise) or results of operations of the Borrower and its Subsidiaries taken as affecting a whole so relevant: (i) the ability by the Borrower to meet its obligations under any Credit Instrument, (ii) the legality, validity, binding effect or enforceability against the Borrower of any Loan Document or (iii) the rights and remedies of the Administrative Agent or the Creditors under the Credit Instruments.
Significant Adverse Effect means a change, situation or event that could reasonably be expected, whether taken individually or in combination with other changes, situations or events, to have a Material adverse effect;
Significant Adverse Effect has the meaning assigned to such term in subsection (f) of Section 4.2.