Examples of PRN in a sentence
Excess retinal thickness (ERT) and total macular volume decreased, and VA improved relative to baseline values.In the Phase II, double-masked, randomized, controlled study DA VINCI (VGFT-OD-0706) of the safety, tolerability and biological effect of repeated IVT administration of VEGF Trap- Eye in patients with clinically significant DME, 2 doses of IVT administered VEGF Trap-Eye (0.5 and 2 mg) at 3 different dosing schedules (every 4 and 8 weeks, PRN) were compared to macular laser photocoagulation.
In addition, the every 8-week dosing paradigm has an advantage over the PRN dosing regimen in that treatment is delivered on a proactive basis and not in response to recurrence of disease.
However, the switch from proactive, fixed dosing at Week 24 to reactive PRN dosing gradually led to a mean loss up to approximately 1 line of BCVA.
The additional dose group studied in the DA VINCI study was 2 mg PRN, in which patients received as needed dosing after 3 initial monthly doses, but were required to be monitored on a monthly basis through Week 52.
In COPERNICUS, starting at Week 52, all subjects were eligible to receive treatment with Eylea to Week 100 in an unmasked 1-year extension phase comprising "as-needed" (PRN) treatment.