Preliminary data definition

Preliminary data means data and results generated by prior research, development, and demonstration and/or unstructured and structured interviews and literature reviews.
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Preliminary data has the meaning set forth in Section 2.09(b).
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Preliminary data. As described above, a stem cell gene therapy approach for monogenic enzyme deficiencies, including those affecting the CNS, have been successful in both clinical trials and in preclinical studies. In establishing whether the same success can be developed for SYNGAP1-realted NSID, the following preliminary data is being presented. The preliminary data presented here is from our previous work on Angelman syndrome and the lentiviral vector expression of a modified form of Ube3a in human CD34+ HSPC transplanted into an immunodeficient and Ube3a-deficient mouse model. The data presented includes significant prevention and reversal of disease phenotypes in Ube3a-deficient mice and the expression of Ube3a in the brains of mice transplanted with Ube3a vector transduced human CD34+ HSPC. Prevention and reversal of Angelman syndrome phenotypes in Ube3a-deficient mice: To demonstrate our ability to develop stem cell gene therapy candidates for monogenic neurological diseases, our previous work in immunodeficient and Ube3a-deficient double knockout mice for the treatment of Angelman syndrome are displayed below. A novel mouse model created by our group, an immunodeficient Ube3a-deficient double knockout mouse model was made so that we could evaluate the in vivo efficacy of our Ube3a-expressing lentiviral vector transduced human CD34+ HSPC (6). We successfully created this mouse model and demonstrated engraftment of human CD34+ HSPC at levels of 20-65% human CD45+ in the peripheral blood as determined by flow cytometry. These levels of human cell engraftment are similar to other immunodeficient mouse models including the NOD-SCID-IL2rg-/- (NSG) and NOD-RAG1-/-IL2rg-/- (NRG) mice (21-22). We next evaluated the in vivo efficacy of the Ube3a vector transduced human CD34+ HSPC to either prevent or reverse motor and behavioral deficits observed in the mouse model. Mice were transplanted as either 2-5 day old pups to evaluate the prevention of disease phenotypes or as 8 week old mice to evaluate the reversal of disease phenotypes. Assays included open field, beam walking, rotarod, gait analysis, novel object recognition, and EEG which are specific for Angelman syndrome phenotypes. As displayed in Figure 1, significant prevention of Angelman syndrome phenotypes were observed in immunodeficient Ube3a-deficient mice transplanted at 2-5 days old with Ube3a vector transduced human CD34+ HSPC (Ube3a-HET). This was in comparison to mice left nontransplanted (HET) or transplanted wi...
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Examples of Preliminary data in a sentence

  • Preliminary data can be an essential part of a research grant application and help to establish the likelihood of success of the proposed project.

  • Preliminary data will be entered into a third party data exchange system to determine probably eligibility.

  • Preliminary data or information pertinent to the proposed research should be included in this section.

  • Preliminary data pertinent to the planned research should be included in this section.

  • Relationship of subjective and objective social status with psychological and physiological functioning: Preliminary data in healthy, White women.

  • Preliminary data (prospectus, circular let-3(b)ters, etc.) to oil offering (Regulation B) (17 CFR 230.300 et seq.).

  • Preliminary data often aid the reviewers in assessing the likelihood of the success of the proposed project.

  • Preliminary data from the National Weather Service shows that between August 24 and September 1, 2017, as much as 64.58 inches of rain fell in parts of Texas, including areas in and around Houston and Beaumont.

  • Preliminary data, including estimates of fish weights or species composition, shall not be submitted on electronic fish tickets.

  • Preliminary data for end-2009 were requested by the IMF by the end of September 2010 and were released in December 2010.


More Definitions of Preliminary data

Preliminary data means a preliminary version of the Data generated pursuant to this Contract supplied to the Client by or on behalf of the Contractor to enable the Client to review the Data and formats. ‘Proposal’ means the schedules and pricing proposal no. Q737 named SkyTEM Proposal_MCWD_Monterey_20170317.pdf.
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Related to Preliminary data

  • Preliminary Work means all work done in the concept and preparatory stages (including non-exhaustively design, artwork, colour matching).

  • Preliminary assessment means the first phase in the process of identifying areas of concern and determining whether contaminants are or were present at a site or have migrated or are migrating from a site, and shall include the initial search for and evaluation of, existing site specific operational and environmental information, both current and historic, to determine if further investigation concerning the documented, alleged, suspected or latent discharge of any contaminant is required. The evaluation of historic information shall be conducted from 1932 to the present, except that the department may require the search for and evaluation of additional information relating to ownership and use of the site prior to 1932 if such information is available through diligent inquiry of the public records.

  • Preliminary Final Prospectus means any preliminary prospectus supplement to the Basic Prospectus which describes the Securities and the offering thereof and is used prior to filing of the Final Prospectus, together with the Basic Prospectus.

  • Preliminary Report means the communication used for the prompt dissemination of data obtained during the early stages of the investigation;

  • Preliminary Title Report A report issued by a title insurance company in anticipation of issuing a Title Insurance policy which evidences existing liens and gives a preliminary opinion as to the absence of any encumbrance on title to a Mortgaged Property, except liens to be removed on or before purchase or refinance, as the case may be, by the Borrower and Permitted Encumbrances.

  • Preliminary Plans means a site plan, architectural floor plans, elevations, outline specifications and a cost estimate for each utility, site development, conversion, and remodeling project. The drawings shall be sufficiently descriptive to accurately convey the location, scope, cost and the nature of the improvement being proposed.

  • Summary data means statistical records and reports derived from data on individuals but in which individuals are not identified and from which neither their identities nor any other characteristic that could uniquely identify the individual is ascertainable.

  • Preliminary plat means a map showing the salient features of a proposed subdivision submitted to an approving authority for purposes of preliminary consideration.

  • Preliminary Closing Statement shall have the meaning set forth in Section 2.3(a).

  • Seller Information As defined in Subsection 34.04(a).

  • preliminary inquiry or "intake" means a mandatory, preadjudicatory interview of the juvenile and, if available, the parents, legal guardian, or other custodian of the juvenile, which is performed by a duly authorized individual to determine whether a juvenile comes within the purview of the Oklahoma Juvenile Code, whether nonadjudicatory alternatives are available and appropriate, and if the filing of a petition is necessary;

  • Preliminary Order means the order proposed by the Settling Parties and approved by the Court in connection with the Motion for Entry of the Preliminary Order to be filed by Class Representatives through Class Counsel, as described in Paragraph 3.2 and in substantially the form attached hereto as Exhibit 2.

  • Preliminary Prospectuses means, collectively, the Canadian Preliminary Prospectus and the Preliminary Prospectus; and “Prospectuses” shall mean, collectively, the Canadian Prospectus and the Prospectus.

  • Preliminary Statement shall have the meaning set forth in Section 2.3(c).

  • Preliminary Approval means the Court’s Order Granting Preliminary Approval of the Settlement.

  • Limited Use Free Writing Prospectus means any Issuer Free Writing Prospectus that is not a General Use Free Writing Prospectus.

  • Limited Use Free Writing Prospectuses means any Issuer Free Writing Prospectus that is not a General Use Free Writing Prospectus.

  • Preliminary Prospectus Supplement means any preliminary prospectus supplement to the Basic Prospectus which describes the Securities and the offering thereof and is used prior to filing of the Prospectus. "Prospectus" shall mean the prospectus supplement relating to the Securities that is first filed pursuant to Rule 424(b) after the Execution Time, together with the Basic Prospectus or, if no filing pursuant to Rule 424(b) is required, shall mean the prospectus supplement relating to the Securities, including the Basic Prospectus, included in the Registration Statement at the Effective Date. "Rule 430A Information" means information with respect to the Securities and the offering of the Securities permitted to be omitted from the Registration Statement when it becomes effective pursuant to Rule 430A. "Rule 415", "Rule 424", "Rule 430A" and "Regulation S-K" refer to such rules or regulations under the Act. Any reference herein to the Registration Statement, the Basic Prospectus, a Preliminary Prospectus Supplement or the Prospectus shall be deemed to refer to and include the documents incorporated by reference therein pursuant to Item 12 of Form S-3 which were filed under the Securities Exchange Act of 1934, as amended (the "Exchange Act"), on or before the Effective Date of the Registration Statement or the issue date of the Basic Prospectus, such Preliminary Prospectus Supplement or the Prospectus, as the case may be; and any reference herein to the terms "amend", "amendment" or "supplement" with respect to the Registration Statement, the Basic Prospectus, any Preliminary Prospectus Supplement or the Prospectus shall be deemed to refer to and include the filing of any document under the Exchange Act after the Effective Date of the Registration Statement, or the issue date of the Basic Prospectus, any Preliminary Prospectus Supplement or the Prospectus, as the case may be, deemed to be incorporated therein by reference.

  • Preliminary Official Statement means the Preliminary Official Statement relating to

  • Appendix Information means the information which must be provided for the selected modules as set out in the Appendix of the Approved EU SCCs (other than the Parties), and which for this Addendum is set out in:

  • Preliminary Offering Memorandum means the Preliminary Offering Memorandum, dated June 19, 2013, relating to the Offered Securities to be offered by the Purchasers.

  • Data Room Information means the information and documents listed in the index of documents contained in the Data Site attached to the Company Disclosure Letter;

  • Line Information Data Base (LIDB) means a transaction-oriented database system that functions as a centralized repository for data storage and retrieval. LIDB is accessible through CCS networks. LIDB contains records associated with End User line numbers and special billing numbers. LIDB accepts queries from other network elements and provides return result, return error, and return reject responses as appropriate. Examples of information that Account Owners might store in LIDB and in their Line Records are: ABS Validation Data, Originating Line Number Screening (OLNS) data, ZIP Code data, and Calling Name Information.

  • Service Information means information concerning the Services provided by the Contractor to the Authority in accordance with Clause 32.1 for inclusion in the Authority's catalogue and/or any Beneficiary's catalogue from time to time;