Lead Optimization definition

Lead Optimization means the stage of early drug discovery where promising
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Lead Optimization means the program of medicinal chemistry research intended to identify structure-activity relationships and apply the knowledge of those relationships to produce compounds having superior properties relative to a Lead Compound.
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Lead Optimization means the preclinical development activities performed for each Collaboration Target following Lead Nomination, with the goal to identify Collaboration Compounds suitable for GLP Tox Studies and meeting CCS Criteria.
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Examples of Lead Optimization in a sentence

  • Aurigene has integrated Discovery capabilities, from Target to Pre-clinical Lead Optimization, including in vitro and in vivo Biology and Medicinal Chemistry expertise.

  • The results will then be assessed by the JSC, and Collaborative Lead Optimization will commence and the selection of [***] for the “Joint Team” will be finalised.

  • Xxxxxx, “Computational Methods Used in Hit-to-Lead and Lead Optimization Stages of Structure-Based Drug Discovery”, Methods Mol Biol., 1705, 375-394 (2018), DOI: 10.1007/978-1-4939-7465- 8_19 - 0 citations, impact factor 0.79 • X.

  • Wednesday, May 12 • BioResearch Product Faire, Life Science seminar, Xxxxxxx Xxxx, Molecular Devices, “Assay Development and Lead Optimization Using Fluorescence Microplate Readers,” 11 a.m., also Xxxxxxx Xxxx, PhD, Bio-Rad Labs, “The Bio-Plex System: A Tool for Profiling Multiple Biomolecules from a Single Sample,” noon, 139 JAH.


More Definitions of Lead Optimization

Lead Optimization. Lead Optimization means the discovery phase dedicated to the evaluation of new AAV Capsid Variants derived from an AAV Capsid Variant Library following a Research Selection Process to identify one or more Research Compounds that meet Delivery Success Criteria.
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Lead Optimization means: (a) the application of medicinal chemistry to improve specificity; (b) optimization of pharmacokinetics and bioavailability; and (c) testing in preclinical studies in animals.
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Lead Optimization has the meaning given in Section 2.d.
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Lead Optimization means the preclinical development activities performed for each Target following Lead Identification, with the goal to identify Degronimids suitable for GLP Tox Studies and satisfying CCS Criteria for such Target.
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Lead Optimization means the process of ***.
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Lead Optimization means shall mean a program of medicinal chemistry the intent of which is to develop a Lead Candidate into a compound or formulation suitable as the subject of an IND submission to the FDA. ​
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Lead Optimization means the set of activities comprised of chemical synthesis, biological and physical testing of ArQule Compounds and Joint Program Compounds with the aim of improving on-target activity, reducing off-target activities and improving physicochemical properties. For clarity, the result of lead optimization is a molecule that encompasses the desired in vitro and in vivo biological and physicochemical properties as defined by the Parties and is ready to be advanced into GLP toxicology studies.
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