0001193125-13-084191 Sample Contracts

FOURTH AMENDMENT TO IRREVOCABLE LICENSE AGREEMENT
Irrevocable License Agreement • February 28th, 2013 • Amarin Corp Plc\uk • Pharmaceutical preparations

WHEREAS, Licensor and Licensee entered into a License Agreement dated April 11, 2011 for an agreed upon 3,303 square feet of office space located at 1420 Route 206, Bedminster, NJ (the “1420 Premises”); a First Amendment dated May 11, 2011 which relocated Licensee to Suite # 200 consisting of an agreed-upon 9,747 square feet of office space located in 1430 Route 206, Bedminster, NJ (the “1430 Premises”); a Second Amendment dated April 25, 2012 and a Third Amendment dated July 17, 2012 (collectively, the “License”); and

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PURCHASE AND SALE AGREEMENT BY AND BETWEEN AMARIN PHARMACEUTICALS IRELAND LIMITED AMARIN CORPORATION PLC AND BIOPHARMA SECURED DEBT FUND II HOLDINGS CAYMAN LP EFFECTIVE AS OF DECEMBER 6, 2012
Purchase and Sale Agreement • February 28th, 2013 • Amarin Corp Plc\uk • Pharmaceutical preparations • New York

THIS PURCHASE AND SALE AGREEMENT (this “Agreement”) is made and entered into as of December 6, 2012 (the “Effective Date”), by and between AMARIN PHARMACEUTICALS IRELAND LIMITED, a company incorporated under the laws of Ireland (registered number 408912) having its registered office at 88 Harcourt Street, Dublin 2, and its permitted successors and assigns (“Seller”), AMARIN CORPORATION PLC, a public limited company incorporated under the laws of England and Wales, and its permitted successors and assigns (“Parent” and, together with Seller, the “Amarin Parties”) and BIOPHARMA SECURED DEBT FUND II HOLDINGS CAYMAN LP, a Cayman Islands exempted limited partnership, and its permitted successors and assigns (“Purchaser”). Purchaser, Seller and Parent are sometimes referred to individually as a “Party” and collectively as the “Parties.” Capitalized terms used but not otherwise defined will have the respective meanings given to such terms in Annex A attached hereto.

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