0001104659-04-027963 Sample Contracts

INDENTURE BETWEEN VERTEX PHARMACEUTICALS INCORPORATED, AS ISSUER AND US BANK NATIONAL ASSOCIATION, AS TRUSTEE 5¾% CONVERTIBLE SENIOR SUBORDINATED NOTES DUE 2011 DATED AS OF SEPTEMBER 17, 2004
Indenture • September 17th, 2004 • Vertex Pharmaceuticals Inc / Ma • Pharmaceutical preparations • New York

INDENTURE, dated as of September 17, 2004, between VERTEX PHARMACEUTICALS INCORPORATED, a corporation duly organized and existing under the laws of the Commonwealth of Massachusetts, having its principal office at 130 Waverly Street, Cambridge, Massachusetts 02139 (the “Company”), and US BANK NATIONAL ASSOCIATION, as trustee (the “Trustee”), having its principal corporate trust office at One Federal Street, Boston, Massachusetts 02110.

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Dated September 13, 2004 VERTEX PHARMACEUTICALS INCORPORATED and UBS SECURITIES LLC DEALER MANAGER AGREEMENT
Dealer Manager Agreement • September 17th, 2004 • Vertex Pharmaceuticals Inc / Ma • Pharmaceutical preparations • New York
RESALE REGISTRATRION RIGHTS AGREEMENT among VERTEX PHARMACEUTICALS INCORPORATED, and UBS Securities LLC as Dealer Manager Dated September 17, 2004
Resale Registratrion Rights Agreement • September 17th, 2004 • Vertex Pharmaceuticals Inc / Ma • Pharmaceutical preparations • New York

Resale Registration Rights Agreement (this “Agreement”), dated September 17, 2004, between Vertex Pharmaceuticals Incorporated, a Massachusetts corporation (together with any successor entity, the “Issuer”), and UBS Securities LLC, as Dealer Manager (the “Dealer Manager”).

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