0001047469-15-004723 Sample Contracts

EMPLOYMENT AGREEMENT
Employment Agreement • May 13th, 2015 • Nivalis Therapeutics, Inc. • Pharmaceutical preparations • Colorado

THIS EMPLOYMENT AGREEMENT (this “Agreement”), effective as of January 21, 2015, is between N30 Pharmaceuticals, Inc., a Delaware corporation (the “Company”), and R. Michael Carruthers (“Employee”).

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Contract
Nivalis Therapeutics, Inc. • May 13th, 2015 • Pharmaceutical preparations • Delaware

THIS WARRANT HAS NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED OR ANY STATE SECURITIES LAWS. NO SALE OR DISPOSITION MAY BE EFFECTED WITHOUT (i) EFFECTIVE REGISTRATION STATEMENTS RELATED THERETO, (ii) AN OPINION OF COUNSEL OR OTHER EVIDENCE, REASONABLY SATISFACTORY TO THE COMPANY, THAT SUCH REGISTRATIONS ARE NOT REQUIRED, (iii) RECEIPT OF NO-ACTION LETTERS FROM THE APPROPRIATE GOVERNMENTAL AUTHORITIES, OR (iv) OTHERWISE COMPLYING WITH THE PROVISIONS OF SECTION 7 OF THIS WARRANT.

AMENDMENT to the EMPLOYMENT AGREEMENT Effective November 1, 2012 between Nivalis Therapeutics, Inc. (formerly known as N30 Pharmaceuticals, Inc.) and Janice M. Troha (“Employee”)
Employment Agreement • May 13th, 2015 • Nivalis Therapeutics, Inc. • Pharmaceutical preparations

WHEREAS, Nivalis Therapeutics, Inc. (formerly known as N30 Pharmaceuticals, Inc. (“Company”)) and the Employee entered into an employment agreement (the “Agreement”) effective as of November 1, 2012;

EMPLOYMENT AGREEMENT
Employment Agreement • May 13th, 2015 • Nivalis Therapeutics, Inc. • Pharmaceutical preparations • Colorado

THIS EMPLOYMENT AGREEMENT (this “Agreement”), effective as of November 1, 2012, is between N30 Pharmaceuticals, Inc., a Delaware corporation (the “Company”), and Janice M. Troha (“Employee”).

AMENDMENT TO EMPLOYMENT AGREEMENT
Noncompete Agreement • May 13th, 2015 • Nivalis Therapeutics, Inc. • Pharmaceutical preparations • Colorado

This Amendment to Employment Agreement (this “Amendment”) is made and entered into as of December 15, 2014 by and between N30 Pharmaceuticals, Inc., a Delaware corporation (the “Company”), and Sherif Gabriel (“Employee”) and amends that certain Employment Agreement between the Company and Employee dated November 1, 2012 (the “Employment Agreement”).

N30 PHARMACEUTICALS, INC. STOCK OPTION AGREEMENT
2012 Stock Incentive Plan • May 13th, 2015 • Nivalis Therapeutics, Inc. • Pharmaceutical preparations • Delaware

N30 Pharmaceuticals, Inc. (the “Company”) hereby grants to the Grantee listed below (the “Grantee”) an option (the “Option”) to purchase the number shares of Common Stock (“Stock”) of the Company set forth below, subject to the terms and conditions of the Plan and this Stock Option Agreement (the “Option Agreement”) including the Exhibits attached hereto, as follows:

SECOND AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT
Investor Rights Agreement • May 13th, 2015 • Nivalis Therapeutics, Inc. • Pharmaceutical preparations • New York

THIS SECOND AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT (this “Agreement”) is made as of November 18, 2014, by and among N30 Pharmaceuticals, Inc., a Delaware corporation (the “Company”), and each of the holders of capital stock of the Company listed on Schedule A hereto (each a “Stockholder” and together the “Stockholders”).

AMENDMENT to the EMPLOYMENT AGREEMENT between Nivalis Therapeutics, Inc. (formerly known as N30 Pharmaceuticals, Inc.) and Jon Congleton (“Employee”)
Employment Agreement • May 13th, 2015 • Nivalis Therapeutics, Inc. • Pharmaceutical preparations

WHEREAS, Nivalis Therapeutics, Inc. (formerly known as N30 Pharmaceuticals, Inc. (the “Company”)) and the Employee entered into an employment agreement (the “Agreement”) effective as of January 1, 2015;

FIRST AMENDMENT TO LEASE
Lease • May 13th, 2015 • Nivalis Therapeutics, Inc. • Pharmaceutical preparations • Colorado

THIS FIRST AMENDMENT TO LEASE (this “Amendment”) is made effective as of the 5th day of December, 2014, by and between AWEIDA PROPERTIES, INC., a Colorado corporation (“Landlord”), and N30 PHARMACEUTICALS, INC. a Delaware Corporation (“Tenant”) to that certain lease dated March 11, 2010 by and between Landlord and Tenant (the “Lease”). Capitalized terms used herein which are defined in the Lease shall have the meanings therein stated.

EMPLOYMENT AGREEMENT
Employment Agreement • May 13th, 2015 • Nivalis Therapeutics, Inc. • Pharmaceutical preparations • Colorado

THIS EMPLOYMENT AGREEMENT (this “Agreement”), effective as of August 7, 2013, is between N30 Pharmaceuticals, Inc., a Delaware corporation (the “Company”), and Charles H. Scoggin (“Employee”).

SECOND AMENDMENT TO LEASE
Lease • May 13th, 2015 • Nivalis Therapeutics, Inc. • Pharmaceutical preparations

THIS SECOND AMENDMENT TO LEASE (this “Amendment”) is made effective as of the Eleventh day of February, 2015, by and between AWEIDA PROPERTIES, INC., a Colorado corporation (“Landlord”), and N30 PHARMACEUTICALS, INC. a Delaware Corporation (formerly, and identified in the Lease as, a Delaware Limited Liability Company) (“Tenant”) to that certain lease dated March 11, 2010 by and between Landlord and Tenant (the “Lease”), as amended by that certain First Amendment to Lease dated December 5, 2014, for the lease of Premises located at 3122 Sterling Circle, Suite 200, Boulder, Colorado 80301. Capitalized terms used herein which are defined in the Lease shall have the meanings therein stated.

LEASE
Lease • May 13th, 2015 • Nivalis Therapeutics, Inc. • Pharmaceutical preparations • Colorado
NIVALIS THERAPEUTICS, INC. INDEMNIFICATION AGREEMENT
Indemnification Agreement • May 13th, 2015 • Nivalis Therapeutics, Inc. • Pharmaceutical preparations • Delaware

This Indemnification Agreement (“Agreement”) is made as of [ ], 20[ ] by and between NIVALIS THERAPEUTICS, INC., a Delaware corporation (the “Company”), and [ ] (“Indemnitee”).

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