0001047469-10-010516 Sample Contracts

EMPLOYMENT AGREEMENT
Employment Agreement • December 21st, 2010 • Newlink Genetics Corp • Iowa

THIS EMPLOYMENT AGREEMENT (the “Agreement”) is made as of this 22nd day of November, 2010, by and between NewLink Genetics Corporation (the “Company”), and Nick Vahanian (“Executive”) (collectively, the “Parties”).

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EXCLUSIVE LICENSE AGREEMENT
Exclusive License Agreement • December 21st, 2010 • Newlink Genetics Corp • Pennsylvania

THIS EXCLUSIVE LICENSE AGREEMENT (the “Agreement”) is made and entered into by and between LANKENAU INSTITUTE FOR MEDICAL RESEARCH (“LIMR”) and NEWLINK GENETICS CORPORATION (“NewLink”) for the licensing of certain intellectual property rights to NewLink, effective on this 23 day of April, 2009 (the “Effective Date”).

NEWLINK GENETICS CORPORATION
Newlink Genetics Corp • December 21st, 2010

Pursuant to your Stock Option Grant Notice ("Grant Notice") and this Stock Option Agreement, NEWLINK GENETICS CORPORATION (the "Company") has granted you an option under its 2009 Equity Incentive Plan (the "Plan") to purchase the number of shares of the Company's Common Stock indicated in your Grant Notice at the exercise price indicated in your Grant Notice. Defined terms not explicitly defined in this Stock Option Agreement but defined in the Plan shall have the same definitions as in the Plan.

EXCLUSIVE LICENSE AGREEMENT between THE REGENTS OF THE UNIVERSITY OF CALIFORNIA and BIOPROTECTION SYSTEMS CORPORATION for
Exclusive License Agreement • December 21st, 2010 • Newlink Genetics Corp • California

This license agreement (“Agreement”) is made effective this 29th day of July, 2008 (“Effective Date”), by and between The Regents of the University of California, a California corporation, having its statewide administrative offices at 1111 Franklin Street, 12th Floor, Oakland, California 94607-5200 (“The Regents”), and acting through its Office of Technology Management, University of California San Francisco (“UCSF”), 185 Berry Street, Suite 4603, San Francisco, California 94107, and BioProtection Systems Corporation, a Delaware corporation, having a principal place of business at 2901 South Loop Drive, Suite 3360, Ames, Iowa 50010-8646 (“Licensee”).

Re: Letter of Intent for a Cooperative Research and Development Agreement #02166
Research and Development Agreement • December 21st, 2010 • Newlink Genetics Corp • District of Columbia

NCI Principal Investigators: Drs. Sherry S. Ansher, Lee Jia and Howard Streicher Collaborator Investigators: Drs. Charles Link and Nicholas Vahanian

LICENSE AGREEMENT BETWEEN NEWLINK GENETICS AND DREXEL UNIVERSITY EFFECTIVE AS OF OCTOBER 13th, 2004
License Agreement • December 21st, 2010 • Newlink Genetics Corp • Delaware

This License Agreement (this “Agreement”) is made on October, 13th, 2004, by and between Drexel University, a Pennsylvania nonprofit corporation, with offices located at 3201 Arch Street, Suite 100, Philadelphia, Pennsylvania 19104 (“DREXEL”), and NewLink Genetics Corporation, a Delaware for-profit corporation (“LICENSEE”), with its principal offices at Iowa State University Research Park, 2901 South Loop Drive, Suite 3900. This Agreement is effective as of October, 13th, 2004 (the “Effective Date”).

LICENSE AGREEMENT Between: THE UNIVERSITY OF BRITISH COLUMBIA and NEWLINK GENETICS CORPORATION Schedules
License Agreement • December 21st, 2010 • Newlink Genetics Corp • British Columbia

THE UNIVERSITY OF BRITISH COLUMBIA, a corporation continued under the University Act of British Columbia with its administrative offices at 2075 Wesbrook Mall, Vancouver, British Columbia, V6T 1W5

CONTRACT AMENDMENT
Newlink Genetics Corp • December 21st, 2010

THIS CONTRACT AMENDMENT is made by and between the IOWA DEPARTMENT OF ECONOMIC DEVELOPMENT, (hereafter “Department” or “IDED”), 200 East Grand Avenue, Des Moines, Iowa 50309, an agency of the State of Iowa and NewLink Genetics Corporation (hereafter “Business”), a Delaware corporation, 2901 South Loop Drive, Suite 3900, Ames, Iowa 50010.

LICENSE AGREEMENT BETTWEEN LANKENAU INSTITUTE FOR MEDICAL RESEARCH AND NEWLINK GENETICS CORPORATION
License Agreement Bettween Lankenau Institute • December 21st, 2010 • Newlink Genetics Corp • Pennsylvania

This License Agreement between Lankenau Institute for Medical Research (“LIMR” or “Institute”) and NewLink Genetics Corporation. (“NewLink” or “Company”) (referred to as “Agreement”) for the licensing of certain intellectual property rights to NewLink is made on this 7th day of July, 2005 (“Effective Date”).

LICENSE AGREEMENT BETWEEN CENTRAL IOWA HEALTH SYSTEM AND NEWLINK GENETICS CORPORATION
License Agreement • December 21st, 2010 • Newlink Genetics Corp • Iowa

THIS LICENSE AGREEMENT (the “Agreement”), by and between CENTRAL IOWA HEALTH SYSTEM, a not-for-profit corporation, organized and existing under the laws of the state of Iowa (“CIHS”), and NEWLINK GENETICS CORPORATION, a Delaware corporation, having a principal place of business at 2901 S. Loop Drive, Ames, Iowa, 50010 (“NEWLINK”) is effective as of the 2nd day of August, 2001(the “Effective Date”). CIHS and NEWLINK are sometimes referred to herein individually as a “Party” and collectively as the “Parties.”

LICENSE AGREEMENT AMENDMENT
License Agreement • December 21st, 2010 • Newlink Genetics Corp

Inasmuch as NewLink Genetics Corporation of Ames, Iowa, and the Medical College of Georgia Research Institute of Augusta Georgia, have a valid and existing License Agreement related to the use of [*] dated September 13, 2005;

HER MAJESTY THE QUEEN IN RIGHT OF CANADA, as represented by the Minister of Health, acting through the Public Health Agency of Canada (“Canada”)
License Agreement • December 21st, 2010 • Newlink Genetics Corp • Ontario

NOW THEREFORE in consideration of the premises, the terms and conditions hereinafter contained and other good and valuable consideration, the receipt of which is hereby acknowledged by each party, the Parties hereto covenant and agree as follows:

AGREEMENT AMENDMENT First Amendment to Agreement Between NewLink Genetics Corporation and Medical College of Georgia Research Institute, Inc.
Agreement • December 21st, 2010 • Newlink Genetics Corp

This first amendment to the agreement is entered into by and between NewLink Genetics Corporation (hereinafter SPONSOR) and the Medical College of Georgia Research Institute, Inc. (hereinafter MCGRI).

IOWA VALUES FUND (IVF) CONTRACT BY AND BETWEEN NEWLINK GENETICS CORPORATION AND THE IOWA DEPARTMENT OF ECONOMIC DEVELOPMENT DATED AS OF MARCH 18, 2005
Iowa Values Fund Contract • December 21st, 2010 • Newlink Genetics Corp • Iowa

This IOWA VALUES FUND CONTRACT (“Contract”) is made this 18th day of March, 2005 ( the “Contract Effective Date”) by and between the Iowa Department of Economic Development (“IDED”) and NewLink Genetics Corporation an Iowa corporation (“Business”).

ECONOMIC DEVELOPMENT COMMUNITY INVESTMENT FUND PROGRAM FORGIVABLE LOAN AGREEMENT (NewLink Genetics Corporation)
Loan Agreement • December 21st, 2010 • Newlink Genetics Corp • Iowa
Memorandum of Agreement
Newlink Genetics Corp • December 21st, 2010

The following information constitutes additions to the Lease Agreement between Iowa State Innovation System- ISIS (Landlord) and NewLink Genetics Corporation (Tenant). Upon signatures of appropriate representatives of Landlord and Tenant affixed to this Memorandum, this Memorandum becomes a part of that Lease Agreement dated February 1, 2001.

NEWLINK GENETICS CORPORATION 2000 EQUITY INCENTIVE PLAN STOCK BONUS AGREEMENT
Newlink Genetics Corp • December 21st, 2010

Pursuant to the Stock Bonus Grant Notice ("Grant Notice") and this Stock Bonus Agreement (collectively, the "Award") and in consideration of your past services, NewLink Genetics Corporation (the "Company") has awarded you a stock bonus under its 2000 Equity Incentive Plan (the "Plan") for the number of shares of the Company's Common Stock subject to the Award as indicated in the Grant Notice. Such issuance is intended to comply with the provisions of Rule 701 promulgated by the Securities and Exchange Commission under the Securities Act of 1933, as amended. Defined terms not explicitly defined in this Stock Bonus Agreement but defined in the Plan shall have the same definitions as in the Plan.

Memorandum of Agreement
Newlink Genetics Corp • December 21st, 2010

The following information constitutes additions to the Lease Agreement between ISU Research Park Corporation (Landlord) and NewLink Genetics Corporation (Tenant). Upon signatures of appropriate representatives of Landlord and Tenant affixed to this Memorandum, this Memorandum becomes a part of that Lease Agreement dated February 1, 2001.

CONTRACT AMENDMENT
Newlink Genetics Corp • December 21st, 2010

THIS CONTRACT AMENDMENT is made by and between the IOWA DEPARTMENT OF ECONOMIC DEVELOPMENT, (hereafter “Department” or “IDED”), 200 East Grand Avenue, Des Moines, Iowa 50309, an agency of the State of Iowa and NewLink Genetics Corporation (hereafter “Business”), a Delaware corporation, 2901 South Loop Drive, Suite 3900, Ames, Iowa 50010.

Contract
License Agreement • December 21st, 2010 • Newlink Genetics Corp • Georgia

THIS LICENSE AGREEMENT is made and entered into as of this 13 day of September, 2005, by and between the MEDICAL COLLEGE OF GEORGIA RESEARCH INSTITUTE, INC., a nonprofit Georgia corporation with offices located in the Medical College of Georgia, 1462 Laney Walker Blvd, Room CA-2125, Augusta, Georgia 30912-4810 (hereinafter referred to as “MCGRI”) and NEWLINK GENETICS CORPORATION, a Delaware corporation with corporate headquarters located at 2901 South Loop Drive Suite 3900, Ames, Iowa 50010 (hereinafter referred to as “LICENSEE”).

LEASE Between Iowa State University Research Park Corporation (Landlord) and NewLink Genetics, Inc. (Tenant) Space: Suite 3900 Wayne R. Moore Technology Transfer Center, Building #3 Date: September 1, 2000 Address of Tenant to which Notices shall be...
Newlink Genetics Corp • December 21st, 2010

Quantities may be increased 100 percent in sprinklered buildings. When footnote 3 also applies, the increase for both footnotes may be applied.

Patent Licence Agreement Date: 1 March 2006 Parties
Licence Agreement • December 21st, 2010 • Newlink Genetics Corp • Victoria
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Memorandum of Agreement
Newlink Genetics Corp • December 21st, 2010

The following information constitutes additions to the Lease Agreement between ISU Research Park Corporation (Landlord) and NewLink Genetics Corporation (Tenant). Upon signatures of appropriate representatives of Landlord and Tenant affixed to this Memorandum, this Memorandum becomes a part of that Lease Agreement dated February 1, 2001.

AMENDMENT #1 COOPERATIVE RESEARCH AND DEVELOPMENT AGREEMENT # 1901
Cooperative Research and Development Agreement • December 21st, 2010 • Newlink Genetics Corp

The purpose of this amendment is to change certain terms of the above-referenced Cooperative Research and Development Agreement (CRADA). These changes are reflected below and except for these changes all other provisions of the original CRADA remain in full force and effect. Two originals of this amendment are provided for execution; one is to remain with the National Cancer Institute and the other copy is to remain with the Collaborator.

LICENSE AGREEMENT AMENDMENT
License Agreement • December 21st, 2010 • Newlink Genetics Corp

Inasmuch as NewLink Genetics Corporation of Ames, Iowa, and the Medical College of Georgia Research Institute of Augusta Georgia, have a valid and existing License Agreement related to the use of [*] dated September 13, 2005;

FIRST AMENDMENT TO LICENSE AGREEMENT BETWEEN LANKENAU INSTITUTE FOR MEDICAL RESEARCH AND NEWLINK GENETICS CORPORATION DATED JULY 7, 2005
License Agreement • December 21st, 2010 • Newlink Genetics Corp

This First Amendment to the License Agreement (“First Amendment”) between Lankenau Institute for Medical Research (“LIMR”) and NewLink Genetics Corporation (“NewLink” or “Company”) is made on this May 22 day of May, 2006 (“Effective Date”).

Memorandum of Agreement
Newlink Genetics Corp • December 21st, 2010

The following information constitutes additions to the Lease Agreement between ISU Research Park Corporation (Landlord) and NewLink Genetics Corporation (Tenant). Upon signatures of appropriate representatives of Landlord and Tenant affixed to this Memorandum, this Memorandum becomes a part of that Lease Agreement dated February 1, 2001.

MASTER CONTRACT BY AND BETWEEN NEWLINK GENETICS CORPORATION AND THE IOWA DEPARTMENT OF ECONOMIC DEVELOPMENT CONTRACT NUMBER: 06-54
Master Contract • December 21st, 2010 • Newlink Genetics Corp • Iowa

This FINANCIAL ASSISTANCE CONTRACT (the “Master Contract”) is made by and between the Iowa Department of Economic Development (“IDED”), 200 East Grand Avenue, Des Moines, IA 50309 and NewLink Genetics Corporation a Delaware Corporation (“Business”), 2901 South Loop Drive, Suite 3900, Ames, Iowa 50010.

SECOND AMENDMENT TO LICENSE AGREEMENT BETWEEN LANKENAU INSTITUTE FOR MEDICAL RESEARCH AND NEWLINK GENETICS CORPORATION DATED JULY 7, 2005
License Agreement • December 21st, 2010 • Newlink Genetics Corp

This Second Amendment to the License Agreement (“Second Amendment”) between Lankenau Institute for Medical Research (“LIMR”) and NewLink Genetics Corporation (“NewLink” or “Company”) is made on this 11th day of September, 2007 (“Effective Date”).

Cooperative Research and Development Agreement (CRADA #1901) NCI Principal Investigator John C. Morris, M.D. Metabolism Branch, CCR, NCI Collaborator Principal Investigator Nicholas Vahanian, M.D. NewLink Genetics Corporation Term of CRADA Four (4)...
Development Agreement • December 21st, 2010 • Newlink Genetics Corp • District of Columbia

This Cooperative Research and Development Agreement, hereinafter referred to as the “CRADA,” consists of this Cover Page, an attached Agreement, and various Appendices referenced in the Agreement. This Cover Page serves to identify the Parties to this CRADA:

Memorandum of Agreement
Newlink Genetics Corp • December 21st, 2010

The following information constitutes additions to the Lease Agreement between ISU Research Park Corporation (Landlord) and NewLink Genetics Corporation (Tenant). Upon signatures of appropriate representatives of Landlord and Tenant affixed to this Memorandum, this Memorandum becomes a part of that Lease Agreement dated February 1, 2001.

NEWLINK GENETICS CORPORATION 2000 EQUITY INCENTIVE PLAN Stock Option Agreement (Incentive Stock Option or Nonstatutory Stock Option)
Newlink Genetics Corp • December 21st, 2010

Pursuant to your Stock Option Grant Notice ("Grant Notice") and this Stock Option Agreement, NewLink Genetics Corporation (the "Company") has granted you an option under its 2000 Equity Incentive Plan (the "Plan") to purchase the number of shares of the Company's Common Stock indicated in your Grant Notice at the exercise price indicated in your Grant Notice. Defined terms not explicitly defined in this Stock Option Agreement but defined in the Plan shall have the same definitions as in the Plan.

CONTRACT AMENDMENT
Newlink Genetics Corp • December 21st, 2010

THIS CONTRACT AMENDMENT is made by and between the IOWA DEPARTMENT OF ECONOMIC DEVELOPMENT, (hereafter “Department” or “IDED”), 200 East Grand Avenue, Des Moines, Iowa 50309, an agency of the State of Iowa and NewLink Genetics Corporation (hereafter “Business”), a Delaware corporation, 2901 South Loop Drive, Suite 3900, Ames, Iowa 50010.

RESEARCH AGREEMENT
Research Agreement • December 21st, 2010 • Newlink Genetics Corp • Georgia

THIS RESEARCH AGREEMENT, (the “Agreement”), effective this 5th day of September, 2006, is entered into by and between NewLink Genetics Corporation, a corporation with its principal place of business at 2901 S. Loop Drive, Suite 3900 Ames, IA 50010 (hereinafter “Sponsor”), and the Medical College of Georgia Research Institute, Inc., (hereinafter “MCGRI”) a non-profit research and educational corporation located at the Medical College of Georgia, Augusta, Georgia 30912-4810.

RESEARCH AGREEMENT
Research Agreement • December 21st, 2010 • Newlink Genetics Corp • Georgia

THIS AGREEMENT, effective this 17th day of Feb 2009, is entered into by and between NewLink Genetics, Inc. a corporation with its principal place of business at 2901 South Loop Drive, Suite 3900, Ames, Iowa 50010, hereinafter (“Sponsor”) and the MEDICAL COLLEGE OF GEORGIA RESEARCH INSTITUTE, INC., (hereinafter “MCGRI”) a non-profit research and educational corporation, located at the Medical College of Georgia, 1120 15th Street, Augusta, Georgia 30912-4810.

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