0000950170-22-003582 Sample Contracts

OPEN MARKET SALE AGREEMENT
Open Market Sale Agreement • March 14th, 2022 • Spruce Biosciences, Inc. • Pharmaceutical preparations • New York

Spruce Biosciences, Inc., a Delaware corporation (the “Company”), proposes, subject to the terms and conditions stated herein, to issue and sell from time to time through Jefferies LLC, as sales agent and/or principal (the “Agent”), shares of the Company’s common stock, par value $0.0001 per share (the “Common Shares”), having an aggregate offering price of up to $21,000,000 on the terms set forth in this agreement (this “Agreement”).

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SEPARATION AND Release Agreement
Separation and Release Agreement • March 14th, 2022 • Spruce Biosciences, Inc. • Pharmaceutical preparations

I, Rosh Dias, understand that my employment with Spruce Biosciences, Inc. (the “Company”) will terminate effective as of March 11, 2022 (the “Separation Date”). As of the Separation Date, I hereby irrevocably resign as Chief Medical Officer of the Company and from any other officer positions I may hold with the Company and any of its subsidiaries.

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